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  2. Keyword: Fatigue
Figure 1
ABCHF
Brief Communication

The Challenge of HFpEF Diagnosis in Brazil

Luiz Cláudio Danzmann et al. Evgeny Belyavskiy Antônio José Lagoeiro Jorge Evandro Tinoco Mesquita Marco Antonio Rodrigues Torres

Abstract

Heart failure with preserved ejection fraction (HFpEF) is highly prevalent in Brazil and worldwide. However, the recent diagnostic criteria for this condition are complex and difficult to apply in the Brazilian health system. This review proposes adapting the modern diagnostic criteria to the needs of each patient, from the primary care to the most complex one, using a system of three steps of complexity and highlighting the importance of searching specific disease etiology.

  • Comorbidity
  • Diagnostic Imaging
  • Dyspmea
  • Echocardiography/methods
  • Fatigue
  • Heart Failure/ophysiopathology
  • Stroke Volume
  • Vascular Stiffness
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Creative Commons Attribution (CC BY) Creative Commons license
06/07/2021 DOI: 10.36660/abchf.20210011 Views 1
Figure 1
ABC
Review Article

Dysautonomia: A Forgotten Condition — Part II

Eduardo Arrais Rocha et al. Niraj Mehta Maria Zildany Pinheiro Távora-Mehta Camila Ferreira Roncari … Alan Alves de Lima Cidrão Jorge Elias Neto

General and Cardiovascular Clinical Manifestations

The pathologies that affect the autonomic nervous system (ANS) can manifest in different ways, depending on the etiology, degree of impairment, disease duration, presence of comorbidities, age or use of associated drugs. Many symptoms can be completely debilitating, such as severe pain in peripheral neuropathy and falls or syncope in autonomic neuropathies. Progression to severe orthostatic intolerance may occur in more advanced cases of dysautonomies, with severe early orthostatic hypotension and supine hypertension, making treatment difficult ().–

[…]

  • Autonomic Nervous System
  • Cardiovascular Autonomic Neuropathy
  • diabetes
  • Fatigue
  • Hypotension, Orthostatic
  • Hypothension, Postural
  • Primary Dysautonomias
  • Syncope
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Creative Commons Attribution (CC BY) Creative Commons license
17/05/2021 DOI: 10.36660/abc.20200422
ABC
Editorial

Angiotensin Receptor-Neprilysin Inhibition Therapy and Improved Exercise Parameters in Heart Failure with Reduced Ejection Fraction

Pedro Schwartzmann

Heart failure (HF) with reduced ejection fraction (HFrEF) has increased significantly in the last three decades and is associated with high morbidity and mortality. In patients with HF, exercise intolerance suggested by dyspnea or fatigue during exertion is the hallmark of the disease. Additionally, health-related quality of life is known to be markedly reduced in HFrEF patients. The severity of this exercise limitation and low quality of life has been shown to correlate to worse prognosis. For this functional and objective assessment, cardiopulmonary exercise testing (CPET) has played an important role on identifying those worse-prognosis patients and has been able to evaluate the effectiveness of different therapies for this HF population, such as the switch of angiotensin-converting enzyme inhibitors (ACEI) to angiotensin receptor neprilysin inhibition (ARNI).

The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial randomized HFrEF patients with New York Heart Association functional class (NYHA) II-IV to the angiotensin receptor neprilysin inhibitor (sacubitril-valsartan) 200 mg twice daily or enalapril 10 mg twice daily and showed a consistent reduction on cardiovascular death, all-cause death and HF-related hospitalizations in the sacubitril-valsartan group. Moreover, the PARADIGM-HF showed improvement in overall quality of life as determined by the Kansas City Cardiomyopathy Questionnaire (KCCQ). Specifically, the greatest baseline limitations and improvements after sacubitril-valsartan were related to activities such as jogging and sexual intercourse, which might be a surrogate marker of better exercise capacity after switching the therapy, although very subjective.

[…]

  • Exercise
  • Fatigue
  • Heart Failure
  • Intolerance
  • Morbidity
  • Mortality
  • Prognosis
  • Stroke Volume
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Creative Commons Attribution (CC BY) Creative Commons license
07/12/2020 DOI: 10.36660/abc.20200566 Views 2
Figure 1
IJCS
Viewpoint

Covid-19 and Safety in the Cath Lab: Where We Are and Where We Are Headed

Giordana Zeferino Mariano et al. Viviana Guzzo Lemke Maria Sanali Moura Paiva Gláucia Maria Moraes de Oliveira

Safety measures in the procedure preparation stage

A study conducted in China with 72,314 patients with COVID-19 (44,672 laboratory-confirmed cases, 16,186 suspected cases, and 10,567 clinically diagnosed cases) has reported fever, cough, dyspnea, myalgia, fatigue and diarrhea as the most common symptoms. Other signs and symptoms have been reported, such as sore throat, chest pain, mental confusion, and lethargy. The authors have highlighted that COVID-19 had a benign course in 80% of the cases, and that many patients, although asymptomatic, could carry the virus. It is worth noting the importance of the differential diagnosis of dyspnea and fatigue, especially when associated with the other symptoms.

During a respiratory pandemic, patients and their families should be informed about the risks of contamination, despite all additional measures taken to minimize them. Because the number of elective procedures will be drastically reduced during that period, the length of hospital stay is predicted to be the minimum necessary for each protocol consensually elaborated. Moreover, defining a procedure as elective requires clinical judgement, because postponing it might have effects that will increase the likelihood of decompensation and adverse events during the pandemic, such as in high-risk patients with unstable angina. Therefore, the decision about performing a procedure should be individualized and based on the patient’s risk and benefit analysis.

[…]

  • Chest Pain
  • Coronavirus
  • Cough
  • COVID-19
  • Diarrhea
  • Dyspnea
  • Fatigue
  • Fever
  • Mental Confusion
  • Myalgia, Cardiovascular Diseases/complications
  • Pandemics
  • Pathological Conditions, Signs and Symptoms
  • Safety
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Creative Commons Attribution (CC BY) Creative Commons license
29/05/2020 DOI: 10.36660/ijcs.20200080 Views 1
Figure 1
ABC
Original Article

Thermoregulation in Hypertensive Rats during Exercise: Effects of Physical Training

Luis Henrique Lobo Silame Gomes et al. Lucas Rios Drummond Helton Oliveira Campos Leonardo Mateus Teixeira de Rezende … Miguel Araújo Carneiro-Júnior Alessandro Oliveira Antônio José Natali Thales Nicolau Prímola-Gomes

Abstract

Background:

Spontaneously hypertensive rats (SHR) show deficit in thermal balance during physical exercise.

Objective:

To assess the effects of low-intensity physical exercise training on thermal balance of hypertensive rats undergoing an acute exercise protocol.

Methods:

Sixteen-week-old male Wistar rats and SHR were allocated into four groups: control Wistar rats (C-WIS), trained Wistar (T-WIS), control SHR (C-SHR) and trained SHR (T-SHR). Treadmill exercise training was performed for 12 weeks. Blood pressure, resting heart rate and total exercise time was measured before and after the physical exercise program. After the exercise program, a temperature sensor was implanted in the abdominal cavity, and the animals subjected to an acute exercise protocol, during which internal body temperature, tail skin temperature and oxygen consumption until fatigue were continuously recorded. Mechanical efficiency (ME), work, heat dissipation threshold and sensitivity were calculated. Statistical significance was set at 5%.

Results:

Physical training and hypertension had no effect on thermal balance during physical exercise. Compared with C-WIS, the T-WIS group showed higher heat production, which was counterbalanced by higher heat dissipation. Hypertensive rats showed lower ME than normotensive rats, which was not reversed by the physical training.

Conclusion:

Low-intensity physical training did not affect thermal balance in SHR subjected to acute exercise.

  • Body Temperature Changes
  • Exercise/physiology
  • Fatigue
  • Hypertension
  • Physical Exertion
  • Rats
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Creative Commons Attribution (CC BY) Creative Commons license
14/03/2019 DOI: 10.5935/abc.20190050 Views 2
ABC
Artigo Original

Morphology and contractility in cardiomyocytes of rats with low exercise performance

Judson Fonseca Quintão Júnior et al. Antônio José Natali Miguel Araújo Carneiro Júnior Cynthia Aparecida de Castro … Lucas Rios Drummond Victor Neiva Lavorato Leonardo Bonato Felix Jader dos Santos Cruz Thales Nicolau Prímola-Gomes

BACKGROUND: Aerobic capacity is essential to physical performance, and low aerobic capacity is related to the triggering of various cardiovascular diseases. OBJECTIVE: To compare the morphology and contractility of isolated rat cardiomyocytes with low performance and standard performance for exercise. METHODS: Wistar rats with 10 weeks of age underwent a protocol of treadmill running to fatigue, and were divided into two groups: Low Performance (LP) and Standard Performance (SP). Then, the animals were sacrificed, the heart was quickly removed and, by means of enzymatic dissociation, left ventricular cardiomyocytes were isolated. The cell and sarcomeres length and width of cardiomyocytes were measured using an edge detection system. The isolated cardiomyocytes were electrically stimulated at 1 and 3 Hz and cell contraction was measured by registering the change of their length. RESULTS: The cell length was shorter in the LP group (157.2 1.3µm; p < 0.05) compared to SP (161.4 1.3µm), and the same result was observed for the volume of cardiomyocytes (LP, 25.5 0.4. vs. SP, 26.8 ± 0.4 pL; p < 0.05). The time to peak contraction (LP, 116 1 vs. SP 111 2ms) and total relaxation (LP, 143 3 vs. SP 232 3ms) were higher in the LP group. CONCLUSION: We conclude that left ventricular myocytes of animals with low performance for exercise are smaller than animals with standard performance. In addition to that, they present losses in contractile capacity.

  • cardiac
  • Exercise
  • Fatigue
  • Myocardial Contraction
  • Myocytes
  • Physical Conditioning, Animal
  • Rats
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Creative Commons Attribution (CC BY) Creative Commons license
12/04/2012 DOI: 10.1590/S0066-782X2012005000036 Views 1
ABC
Artigo Original

Correlation between quality of life and functional capacity in cardiac failure

Ivan Daniel Bezerra Nogueira et al. Denise Maria Servantes Patrícia Angélica de Miranda Silva Nogueira Amália Pelcerman … Xiomara Miranda Salvetti Fernando Salles Dirceu Rodrigues Almeida Marco Túlio de Mello Orlando Campos Filho Japy Angelini Oliveira Filho

BACKGROUND: Patients with cardiac failure (CF) present progressive incapacity and decreased quality of life, both related to dyspnea and fatigue. Thus, there is the increasing interest in measring the quality of life (QL), by generic instrument, such as the 36-item Short-Form Health Survey (SF-36), by specific instrument, such as Minnesota Living with Heart Failure (MLHFQ). OBJECTIVE: This study has the objective to correlate the QL surveys, SF-36 and MLHFQ, with the functional capacity of patients with CF, expressed by the cardiopulmonary test and the TC6M. METHODS: Using the SF-36 and MLHFQ surveys for QL evaluation, for the evaluation of the functional capacity, it was used the cardiopulmonary test, being executed using a tredmill with Weber protocol, as well sa the distance covered in the walk test of six minutes (TC6M). RESULTS: Forty-six patients were selected with CF diagnosis (22 men, average age of 52 years old), classes II and III of New York Heart Association. It was observed that the mild correlation between the physical and emotional domains of SF-36 and VE/VCO2.peak (r=-0.3; p<0.05) and the distance covered in TC6M (r=0.4; p<0.05), respectively. It was also observed the mild to moderate correlations of MLHFQ total score with VO2.peak (r=-0.5; p<0.05), the aerobic threshold (r=-0.4; p<0.05) and the distance covered in TC6M (r=-0.5; p<0.05). CONCLUSION: The data suggest that the application of both evaluation instruments of QL, generic (SF-36) and specific (MLHFQ) in patients with CF, showed mild and moderate correlation with the variable of the cardiopulmonary test with the variables of the cardiopulmonary test and the distance covered in TC6M.

  • Dyspnea
  • Fatigue
  • Heart Failure
  • Quality of life
  • Respiratory Function Tests
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Creative Commons Attribution (CC BY) Creative Commons license
23/07/2010 DOI: 10.1590/S0066-782X2010005000096

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Danzmann LC, Belyavskiy E, Jorge AJL, Mesquita ET, Torres MAR. The Challenge of HFpEF Diagnosis in Brazil. ABC: Heart Failure & Cardiomyopathy 2021;1(1):63-6.

Electronic Document Format (ABNT)

Danzmann, Luiz Cláudio; Belyavskiy, Evgeny; Jorge, Antônio José Lagoeiro; Mesquita, Evandro Tinoco; Torres, Marco Antonio Rodrigues. The Challenge of HFpEF Diagnosis in Brazil. ABC: Heart Failure & Cardiomyopathy, v. 1, n. 1, p. 63-66, Jul. 2021.

Electronic Document Format (APA)

Danzmann, L. C., Belyavskiy, E., Jorge, A. J. L., Mesquita, E. T., & Torres, M. A. R. (2021). The Challenge of HFpEF Diagnosis in Brazil. ABC: Heart Failure & Cardiomyopathy, 1(1), 63-66.

Electronic Document Format (ISO)

Danzmann, Luiz Cláudio and Belyavskiy, Evgeny and Jorge, Antônio José Lagoeiro and Mesquita, Evandro Tinoco and Torres, Marco Antonio Rodrigues. The Challenge of HFpEF Diagnosis in Brazil. ABC: Heart Failure & Cardiomyopathy [online]. 2021, vol. 1, n. 1, [cited 2026-10-14], pp. 63-66. Available from: <https://journals.cardiol.br/en/article/the-challenge-of-hfpef-diagnosis-in-brazil/>

EndNote RIS

Electronic Document Format (Vancouver)

Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J. Dysautonomia: A Forgotten Condition — Part II. Arquivos Brasileiros de Cardiologia 2021;116(5):981-98.

Electronic Document Format (ABNT)

Rocha, Eduardo Arrais; Mehta, Niraj; Távora-Mehta, Maria Zildany Pinheiro; Roncari, Camila Ferreira; Cidrão, Alan Alves de Lima; Elias Neto, Jorge. Dysautonomia: A Forgotten Condition — Part II. Arquivos Brasileiros de Cardiologia, v. 116, n. 5, p. 981-998, May. 2021.

Electronic Document Format (APA)

Rocha, E. A., Mehta, N., Távora-Mehta, M. Z. P., Roncari, C. F., Cidrão, A. A. L., & Elias Neto, J. (2021). Dysautonomia: A Forgotten Condition — Part II. Arquivos Brasileiros de Cardiologia, 116(5), 981-998.

Electronic Document Format (ISO)

Rocha, Eduardo Arrais and Mehta, Niraj and Távora-Mehta, Maria Zildany Pinheiro and Roncari, Camila Ferreira and Cidrão, Alan Alves de Lima and Elias Neto, Jorge. Dysautonomia: A Forgotten Condition — Part II. Arquivos Brasileiros de Cardiologia [online]. 2021, vol. 116, n. 5, [cited 2026-10-14], pp. 981-998. Available from: <https://journals.cardiol.br/en/article/dysautonomia-a-forgotten-condition-part-ii/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Schwartzmann P. Angiotensin Receptor-Neprilysin Inhibition Therapy and Improved Exercise Parameters in Heart Failure with Reduced Ejection Fraction. Arquivos Brasileiros de Cardiologia 2020;115(5):828-9.

Electronic Document Format (ABNT)

Schwartzmann, Pedro. Angiotensin Receptor-Neprilysin Inhibition Therapy and Improved Exercise Parameters in Heart Failure with Reduced Ejection Fraction. Arquivos Brasileiros de Cardiologia, v. 115, n. 5, p. 828-829, Dec. 2020.

Electronic Document Format (APA)

Schwartzmann, P. (2020). Angiotensin Receptor-Neprilysin Inhibition Therapy and Improved Exercise Parameters in Heart Failure with Reduced Ejection Fraction. Arquivos Brasileiros de Cardiologia, 115(5), 828-829.

Electronic Document Format (ISO)

Schwartzmann, Pedro. Angiotensin Receptor-Neprilysin Inhibition Therapy and Improved Exercise Parameters in Heart Failure with Reduced Ejection Fraction. Arquivos Brasileiros de Cardiologia [online]. 2020, vol. 115, n. 5, [cited 2026-10-14], pp. 828-829. Available from: <https://journals.cardiol.br/en/article/angiotensin-receptor-neprilysin-inhibition-therapy-and-improved-exercise-parameters-in-heart-failure-with-reduced-ejection-fraction/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Mariano GZ, Lemke VG, Paiva MSM, Oliveira GMM. Covid-19 and Safety in the Cath Lab: Where We Are and Where We Are Headed. International Journal of Cardiovascular Sciences 2020;33(3):288-94.

Electronic Document Format (ABNT)

Mariano, Giordana Zeferino; Lemke, Viviana Guzzo; Paiva, Maria Sanali Moura; Oliveira, Gláucia Maria Moraes de. Covid-19 and Safety in the Cath Lab: Where We Are and Where We Are Headed. International Journal of Cardiovascular Sciences, v. 33, n. 3, p. 288-294, May. 2020.

Electronic Document Format (APA)

Mariano, G. Z., Lemke, V. G., Paiva, M. S. M., & Oliveira, G. M. M. (2020). Covid-19 and Safety in the Cath Lab: Where We Are and Where We Are Headed. International Journal of Cardiovascular Sciences, 33(3), 288-294.

Electronic Document Format (ISO)

Mariano, Giordana Zeferino and Lemke, Viviana Guzzo and Paiva, Maria Sanali Moura and Oliveira, Gláucia Maria Moraes de. Covid-19 and Safety in the Cath Lab: Where We Are and Where We Are Headed. International Journal of Cardiovascular Sciences [online]. 2020, vol. 33, n. 3, [cited 2026-10-14], pp. 288-294. Available from: <https://journals.cardiol.br/en/article/covid-19-and-safety-in-the-cath-lab-where-we-are-and-where-we-are-headed/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Gomes LHLS, Drummond LR, Campos HO, Rezende LMT, Carneiro-Júnior MA, Oliveira A, Natali AJ, et al. Thermoregulation in Hypertensive Rats during Exercise: Effects of Physical Training. Arquivos Brasileiros de Cardiologia 2019;112(5):534-42.

Electronic Document Format (ABNT)

Gomes, Luis Henrique Lobo Silame; Drummond, Lucas Rios; Campos, Helton Oliveira; Rezende, Leonardo Mateus Teixeira de; Carneiro-Júnior, Miguel Araújo; Oliveira, Alessandro; Natali, Antônio José; Prímola-Gomes, Thales Nicolau. Thermoregulation in Hypertensive Rats during Exercise: Effects of Physical Training. Arquivos Brasileiros de Cardiologia, v. 112, n. 5, p. 534-542, Mar. 2019.

Electronic Document Format (APA)

Gomes, L. H. L. S., Drummond, L. R., Campos, H. O., Rezende, L. M. T. , Carneiro-Júnior, M. A., Oliveira, A., Natali, A. J., & Prímola-Gomes, T. N. (2019). Thermoregulation in Hypertensive Rats during Exercise: Effects of Physical Training. Arquivos Brasileiros de Cardiologia, 112(5), 534-542.

Electronic Document Format (ISO)

Gomes, Luis Henrique Lobo Silame and Drummond, Lucas Rios and Campos, Helton Oliveira and Rezende, Leonardo Mateus Teixeira de and Carneiro-Júnior, Miguel Araújo and Oliveira, Alessandro and Natali, Antônio José and Prímola-Gomes, Thales Nicolau. Thermoregulation in Hypertensive Rats during Exercise: Effects of Physical Training. Arquivos Brasileiros de Cardiologia [online]. 2019, vol. 112, n. 5, [cited 2026-10-14], pp. 534-542. Available from: <https://journals.cardiol.br/en/article/thermoregulation-in-hypertensive-rats-during-exercise-effects-of-physical-training/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Quintão Júnior JF, Natali AJ, Carneiro Júnior MA, Castro CA, Drummond LR, Lavorato VN, Felix LB, et al. Morphology and contractility in cardiomyocytes of rats with low exercise performance. Arquivos Brasileiros de Cardiologia 2012;98(5):431-6.

Electronic Document Format (ABNT)

Quintão Júnior, Judson Fonseca; Natali, Antônio José; Carneiro Júnior, Miguel Araújo; Castro, Cynthia Aparecida de; Drummond, Lucas Rios; Lavorato, Victor Neiva; Felix, Leonardo Bonato; Cruz, Jader dos Santos; Prímola-Gomes, Thales Nicolau. Morphology and contractility in cardiomyocytes of rats with low exercise performance. Arquivos Brasileiros de Cardiologia, v. 98, n. 5, p. 431-436, Apr. 2012.

Electronic Document Format (APA)

Quintão Júnior, J. F., Natali, A. J., Carneiro Júnior, M. A., Castro, C. A. , Drummond, L. R., Lavorato, V. N., Felix, L. B., Cruz, J. S., & Prímola-Gomes, T. N. (2012). Morphology and contractility in cardiomyocytes of rats with low exercise performance. Arquivos Brasileiros de Cardiologia, 98(5), 431-436.

Electronic Document Format (ISO)

Quintão Júnior, Judson Fonseca and Natali, Antônio José and Carneiro Júnior, Miguel Araújo and Castro, Cynthia Aparecida de and Drummond, Lucas Rios and Lavorato, Victor Neiva and Felix, Leonardo Bonato and Cruz, Jader dos Santos and Prímola-Gomes, Thales Nicolau. Morphology and contractility in cardiomyocytes of rats with low exercise performance. Arquivos Brasileiros de Cardiologia [online]. 2012, vol. 98, n. 5, [cited 2026-10-14], pp. 431-436. Available from: <https://journals.cardiol.br/en/article/morphology-and-contractility-in-cardiomyocytes-of-rats-with-low-exercise-performance/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Nogueira IDB, Servantes DM, Nogueira PAMS, Pelcerman A, Salvetti XM, Salles F, Almeida DR, et al. Correlation between quality of life and functional capacity in cardiac failure. Arquivos Brasileiros de Cardiologia 2010;95(2):238-43.

Electronic Document Format (ABNT)

Nogueira, Ivan Daniel Bezerra; Servantes, Denise Maria; Nogueira, Patrícia Angélica de Miranda Silva; Pelcerman, Amália; Salvetti, Xiomara Miranda; Salles, Fernando; Almeida, Dirceu Rodrigues; Mello, Marco Túlio de; Campos Filho, Orlando; Oliveira Filho, Japy Angelini. Correlation between quality of life and functional capacity in cardiac failure. Arquivos Brasileiros de Cardiologia, v. 95, n. 2, p. 238-243, Jul. 2010.

Electronic Document Format (APA)

Nogueira, I. D. B., Servantes, D. M., Nogueira, P. A. M. S., Pelcerman, A., Salvetti, X. M., Salles, F., Almeida, D. R., Mello, M. T. , Campos Filho, O., & Oliveira Filho, J. A. (2010). Correlation between quality of life and functional capacity in cardiac failure. Arquivos Brasileiros de Cardiologia, 95(2), 238-243.

Electronic Document Format (ISO)

Nogueira, Ivan Daniel Bezerra and Servantes, Denise Maria and Nogueira, Patrícia Angélica de Miranda Silva and Pelcerman, Amália and Salvetti, Xiomara Miranda and Salles, Fernando and Almeida, Dirceu Rodrigues and Mello, Marco Túlio de and Campos Filho, Orlando and Oliveira Filho, Japy Angelini. Correlation between quality of life and functional capacity in cardiac failure. Arquivos Brasileiros de Cardiologia [online]. 2010, vol. 95, n. 2, [cited 2026-10-14], pp. 238-243. Available from: <https://journals.cardiol.br/en/article/correlation-between-quality-of-life-and-functional-capacity-in-cardiac-failure/>. ISSN 0066-782X

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