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  2. Keyword: Systemic Lupus Erythematosus
Figure 1
IJCS
Case Report

A Rare and Fatal Association With SLE: Lutembacher Syndrome With Huge Atrial Septal Defect

Muhammed Fatih Kaleli et al. Yakup Alsancak Mustafa Celik Mehmet Akif Düzenli

Introduction

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by periods of relapse and remission, with the potential to damage multiple organs depending on disease activity and individual susceptibility. Valvular heart disease is one of the cardiac manifestations associated with SLE. Lutembacher syndrome (LS) is an exceedingly rare clinical syndrome defined by the presence of a combination of congenital or acquired ostium secundum atrial septal defect (ASD) and congenital or acquired mitral stenosis (MS). First reported by Lutembacher in 1916, this syndrome is more frequently observed in young adults, with a higher prevalence among females. In this case report, we present the case of a young pregnant woman with SLE who visited the cardiology clinic complaining of palpitations. Eventually, she was diagnosed with LS.

[…]

  • Atrial Heart Septal Defects
  • Case Reports
  • Lutembacher Syndrome
  • Systemic Lupus Erythematosus
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Creative Commons Attribution (CC BY) Creative Commons license
28/04/2025 DOI: 10.36660/ijcs.20240116 Views 1
Figure 1
ABC
Anatomopathological Session

Case 2/2014 – 51-Year Old Patient with Systemic Lupus Erythematosus and Fever after Valve Replacement

Wilma Noia Ribeiro et al. Alice Tatsuko Yamada Paulo Sampaio Gutierrez

Clinical aspects

The clinical case reports a 51-year old patient with systemic lupus erythematosus, arterial hypertension and mixed dyslipidemia, who went to the emergency room with fever and in shock.

The systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, which is characterized by the immune complex deposition in the involved organs, including the heart. Its clinical picture is determined by periods of exacerbations and remission, with variable clinical course and prognosis.

[…]

  • Aortic valve stenosis / surgery
  • dyslipidemia
  • Hypertension
  • Systemic Lupus Erythematosus
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Creative Commons Attribution (CC BY) Creative Commons license
01/05/2014 DOI: 10.5935/abc.20140069 Views 1
A rare association of systemic lupus erythematosus, morbid obesity and Takotsubo Syndrome
ABC
Case Report

A rare association of systemic lupus erythematosus, morbid obesity and Takotsubo Syndrome

João Gaspar Corrêa Meyer Neto et al. Claudio Buarque Benchimol Guilherme Loures Penna Luiz Antônio Ferreira Carvalho Maria Carolina Pessoa

The authors report a 68-year-old white female with long-term systemic lupus erythematosus as well as morbid obesity, characterized by very elevated body mass index, who presented a classical picture of acute coronary failure ascribed to Takotsubo syndrome.

  • cardiopatithy obesity
  • Systemic Lupus Erythematosus
  • Takotsubo syndrome
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21/11/2006 DOI: 10.1590/S0066-782X2006001700028
ABC
Artigo Original

Is systemic lupus erithematosus a new risk factor for atherosclerosis?

Beatriz Funayama Alvarenga Freire et al. Rogério Cardoso da Silva Alexandre Todorovic Fabro Daniela Cristina dos Santos

OBJECTIVE: To evaluate the prevalence of cardiovascular events (CVE) secondary to atherosclerosis in lupus patients and correlate them to the traditional risk factors, disease duration and drug therapy used. METHODS: A retrospective study was carried out based on data obtained from patients’ charts. Patients included were those who had a lupus diagnosis confirmed at least two years before inclusion in the study and had been followed since 1992. CVE were characterized as MI, angina pectoris and stroke non-related to lupus activity. Risk factors and drugs used for treatment were recorded. RESULTS: Seventy-one charts were analyzed. Patients’ mean age was 34.2±12.7 years; 68 were women and three were men; 58 were Caucasian (81.6%). Ten (14.08%) presented CVE. Patients in whom CVE were observed were older (42.7 vs. 32.8 years p=0.0021) and presented longer disease duration (10.8 vs. 7.2 years p=0.011). The traditional risk factors, daily and cumulative doses of steroids, immunosuppressive drugs and antimalarial drugs were not significant when patients with and without CVE were compared. CONCLUSION: The prevalence of CVE secondary to atherosclerosis in systemic lupus erythematosus (SLE) was 14.08%. The traditional risk factors were not associated with the development of CVE in lupus patients. Patients that presented cardiovascular events were older and presented longer disease duration. It is a premature conclusion to establish SLE as an independent risk factor for atherosclerosis development.

  • Atherosclerosis
  • Cardiovascular disease
  • Systemic Lupus Erythematosus
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16/10/2006 DOI: 10.1590/S0066-782X2006001600012 Views 1
Cardiac tamponade in systemic lupus erythematosus. Report of four cases
ABC
Brief Communication

Cardiac tamponade in systemic lupus erythematosus. Report of four cases

Márcia Bueno Castier et al. Elisa M. Neves Albuquerque Maria Eduarda F. Costa Castro Menezes Evandro Klumb Francisco Manes Albanesi Fº

OBJECTIVE: To report and assess the incidence of cardiac tamponade in systemic lupus erythematosus as a cardiac manifestation of the disease. METHODS: We reviewed the medical records of 325 patients diagnosed with systemic lupus erythematosus according to the American Rheumatism Association and their complementary laboratory tests compatible with cardiac tamponade. RESULTS: In the 325 medical recors reviewed, we found 108 patients with pericardial effusions corresponding to 33.2% of the total and 54% of the patients studied in the active phase of the disease. Clinical assessment and transthoracic echocardiogram allowed the clinical diagnosis of cardiac tamponade in only 4 (1.23%) patients, 3 of whom were females, white, with ages ranging from 25 to 44 years. The pericardial fluid was hemorrhagic or serosanguineous with high levels of FAN and positivity for LE cells. In the treatment, we successfully used pericardicentesis associated with high doses of corticosteroids. In clinical and laboratory follow-up performed for a period of 3 years, neither recrudescence of the pericardial effusion nor evolution to constriction occurred. CONCLUSION: Even though rare (1.23%), cardiac tamponade in patients with systemic lupus erythematosus has a benign evolution when properly treated, according to our experience.

  • Cardiac Tamponade
  • Pericardial Effusion
  • Systemic Lupus Erythematosus
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21/11/2000 DOI: 10.1590/S0066-782X2000001100008 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Kaleli MF, Alsancak Y, Celik M, Düzenli MA. A Rare and Fatal Association With SLE: Lutembacher Syndrome With Huge Atrial Septal Defect. International Journal of Cardiovascular Sciences 2025;38:e20240116.

Electronic Document Format (ABNT)

Kaleli, Muhammed Fatih; Alsancak, Yakup; Celik, Mustafa; Düzenli, Mehmet Akif. A Rare and Fatal Association With SLE: Lutembacher Syndrome With Huge Atrial Septal Defect. International Journal of Cardiovascular Sciences, v. 38, e20240116, Apr. 2025.

Electronic Document Format (APA)

Kaleli, M. F., Alsancak, Y., Celik, M., & Düzenli, M. A. (2025). A Rare and Fatal Association With SLE: Lutembacher Syndrome With Huge Atrial Septal Defect. International Journal of Cardiovascular Sciences, 38, e20240116.

Electronic Document Format (ISO)

Kaleli, Muhammed Fatih and Alsancak, Yakup and Celik, Mustafa and Düzenli, Mehmet Akif. A Rare and Fatal Association With SLE: Lutembacher Syndrome With Huge Atrial Septal Defect. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [cited 2026-10-14], e20240116. Available from: <https://journals.cardiol.br/en/article/a-rare-and-fatal-association-with-sle-lutembacher-syndrome-with-huge-atrial-septal-defect/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Ribeiro WN, Yamada AT, Gutierrez PS. Case 2/2014 – 51-Year Old Patient with Systemic Lupus Erythematosus and Fever after Valve Replacement. Arquivos Brasileiros de Cardiologia 2014;102(5):e44-51.

Electronic Document Format (ABNT)

Ribeiro, Wilma Noia; Yamada, Alice Tatsuko; Gutierrez, Paulo Sampaio. Case 2/2014 – 51-Year Old Patient with Systemic Lupus Erythematosus and Fever after Valve Replacement. Arquivos Brasileiros de Cardiologia, v. 102, n. 5, p. e44-e51, Apr. 2014.

Electronic Document Format (APA)

Ribeiro, W. N., Yamada, A. T., & Gutierrez, P. S. (2014). Case 2/2014 – 51-Year Old Patient with Systemic Lupus Erythematosus and Fever after Valve Replacement. Arquivos Brasileiros de Cardiologia, 102(5), e44-e51.

Electronic Document Format (ISO)

Ribeiro, Wilma Noia and Yamada, Alice Tatsuko and Gutierrez, Paulo Sampaio. Case 2/2014 – 51-Year Old Patient with Systemic Lupus Erythematosus and Fever after Valve Replacement. Arquivos Brasileiros de Cardiologia [online]. 2014, vol. 102, n. 5, [cited 2026-10-14], pp. e44-e51. Available from: <https://journals.cardiol.br/en/article/case-2-2014-51-year-old-patient-with-systemic-lupus-erythematosus-and-fever-after-valve-replacement/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Meyer Neto JGC, Benchimol CB, Penna GL, Carvalho LAF, Pessoa MC. A rare association of systemic lupus erythematosus, morbid obesity and Takotsubo Syndrome. Arquivos Brasileiros de Cardiologia 2006;87(4):e116-21.

Electronic Document Format (ABNT)

Meyer Neto, João Gaspar Corrêa; Benchimol, Claudio Buarque; Penna, Guilherme Loures; Carvalho, Luiz Antônio Ferreira; Pessoa, Maria Carolina. A rare association of systemic lupus erythematosus, morbid obesity and Takotsubo Syndrome. Arquivos Brasileiros de Cardiologia, v. 87, n. 4, p. e116-e121, Nov. 2006.

Electronic Document Format (APA)

Meyer Neto, J. G. C., Benchimol, C. B., Penna, G. L., Carvalho, L. A. F., & Pessoa, M. C. (2006). A rare association of systemic lupus erythematosus, morbid obesity and Takotsubo Syndrome. Arquivos Brasileiros de Cardiologia, 87(4), e116-e121.

Electronic Document Format (ISO)

Meyer Neto, João Gaspar Corrêa and Benchimol, Claudio Buarque and Penna, Guilherme Loures and Carvalho, Luiz Antônio Ferreira and Pessoa, Maria Carolina. A rare association of systemic lupus erythematosus, morbid obesity and Takotsubo Syndrome. Arquivos Brasileiros de Cardiologia [online]. 2006, vol. 87, n. 4, [cited 2026-10-14], pp. e116-e121. Available from: <https://journals.cardiol.br/en/article/a-rare-association-of-systemic-lupus-erythematosus-morbid-obesity-and-takotsubo-syndrome/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Freire BFA, Silva RC, Fabro AT, Santos DC. Is systemic lupus erithematosus a new risk factor for atherosclerosis?. Arquivos Brasileiros de Cardiologia 2006;87(3):300-6.

Electronic Document Format (ABNT)

Freire, Beatriz Funayama Alvarenga; Silva, Rogério Cardoso da; Fabro, Alexandre Todorovic; Santos, Daniela Cristina dos. Is systemic lupus erithematosus a new risk factor for atherosclerosis?. Arquivos Brasileiros de Cardiologia, v. 87, n. 3, p. 300-306, Oct. 2006.

Electronic Document Format (APA)

Freire, B. F. A., Silva, R. C. , Fabro, A. T., & Santos, D. C. (2006). Is systemic lupus erithematosus a new risk factor for atherosclerosis?. Arquivos Brasileiros de Cardiologia, 87(3), 300-306.

Electronic Document Format (ISO)

Freire, Beatriz Funayama Alvarenga and Silva, Rogério Cardoso da and Fabro, Alexandre Todorovic and Santos, Daniela Cristina dos. Is systemic lupus erithematosus a new risk factor for atherosclerosis?. Arquivos Brasileiros de Cardiologia [online]. 2006, vol. 87, n. 3, [cited 2026-10-14], pp. 300-306. Available from: <https://journals.cardiol.br/en/article/is-systemic-lupus-erithematosus-a-new-risk-factor-for-atherosclerosis/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Castier MB, Albuquerque EMN, Menezes MEFCC, Klumb E, Fº FMA. Cardiac tamponade in systemic lupus erythematosus. Report of four cases. Arquivos Brasileiros de Cardiologia 2000;75(5):446-8.

Electronic Document Format (ABNT)

Castier, Márcia Bueno; Albuquerque, Elisa M. Neves; Menezes, Maria Eduarda F. Costa Castro; Klumb, Evandro; Fº, Francisco Manes Albanesi. Cardiac tamponade in systemic lupus erythematosus. Report of four cases. Arquivos Brasileiros de Cardiologia, v. 75, n. 5, p. 446-448, Nov. 2000.

Electronic Document Format (APA)

Castier, M. B., Albuquerque, E. M. N., Menezes, M. E. F. C. C., Klumb, E., & Fº, F. M. A. (2000). Cardiac tamponade in systemic lupus erythematosus. Report of four cases. Arquivos Brasileiros de Cardiologia, 75(5), 446-448.

Electronic Document Format (ISO)

Castier, Márcia Bueno and Albuquerque, Elisa M. Neves and Menezes, Maria Eduarda F. Costa Castro and Klumb, Evandro and Fº, Francisco Manes Albanesi. Cardiac tamponade in systemic lupus erythematosus. Report of four cases. Arquivos Brasileiros de Cardiologia [online]. 2000, vol. 75, n. 5, [cited 2026-10-14], pp. 446-448. Available from: <https://journals.cardiol.br/en/article/cardiac-tamponade-in-systemic-lupus-erythematosus-report-of-four-cases/>. ISSN 0066-782X

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