Medical Oncology – ABC CARDIOL

ABC

Editorial

Association between Cardiac Metabolic Patterns in Oncological PET/CT and Cardiovascular Risk Factors. Contribution to the Early Investigation of Cardiotoxicity

Introduction

The advancement of cancer therapies in recent decades has radically transformed the prognosis of various types of cancer, significantly improving patient survival. However, this progress has brought a significant increase in cardiovascular (CV) complications.

In this scenario, cardio-oncology has established itself as an essential field, requiring diagnostic strategies with ever-increasing accuracy in the early identification of cardiological impairments, even in the subclinical phase, in addition to the implementation of appropriate monitoring and control plans.

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ABC

Case Report

Takotsubo Syndrome in an Adolescent Undergoing Oncological Treatment: A Rare Case Report

Tami Inada et al. Guilherme Santos Marques da Silva Raisa Machado Amaral Edgard Ferreira dos Santos Junior Carlos Eduardo de Barros Branco

Introduction

Takotsubo Syndrome (TTS), or Takotsubo cardiomyopathy, was first described in Japan in 1990 and is characterized by transient and acute dysfunction of the left ventricle, usually with hypokinesia or akinesia of the mid-apical LV segments and hyperkinesia of the basal segments. The resulting morphology, with apical ballooning, resembles an octopus trap (“tako-tsubo”). Despite its symptoms being similar to those of acute coronary syndrome, there is no coronary obstruction, and the ventricular wall motion abnormality usually extends beyond the territory of a single artery.^,

Several factors can precipitate TTS, particularly physical triggers (such as severe infections and surgical interventions) and emotional stress. In oncology patients, the incidence is higher, attributed to treatment-related toxicity, subsequent infectious complications, and physical and psychological overload.^, The literature indicates that oncology patients present higher mortality and more combined major adverse cardiac events when they develop TTS, especially compared to those without a history of cancer.

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ABC

Case Report

A Rare Cause and Management of Ventricular Fibrillation: 5-Fluorouracil Toxicity

Kutluhan Eren Hazir et al. Cenk Sari

Introduction

5-Fluorouracil (5-FU) is a pyrimidine antimetabolite used to treat solid tumors. 5-FU can cause several cardiovascular side effects with a frequency of 1.2-18%., Among these side effects, angina and myocardial infarction are common. Other rare side effects have also been reported, including myocarditis, pericarditis, arrhythmias including atrial fibrillation, QT prolongation, heart failure, and death. These conditions have been directly associated with vasospasm due to endothelial dysfunction.,

This case report details the diagnosis and management of 5-FU cardiotoxicity upon the development of VF in a patient treated with 5-FU.

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ABCHF

Editorial

Cardio-Protection Against Cancer Treatment-Related Cardiac Dysfunction: Who is at Risk?

Ariane Vieira Scarlatelli Macedo et al. Wolney de Andrade Martins

Long-term survival of cancer patients has improved, and the sequelae of treatment have become more evident. Mortality rates of cancer patients, adjusted for age, have decreased globally, with a reduction by 17% from 1990 to 2019.

The prevention of left ventricular dysfunction secondary to cancer treatment is still a medical challenge. Drug-induced cardiotoxicity is the main limiting factor for the administration of higher doses of anthracyclines. Addressing the anthracycline-induced cardiotoxicity is particularly important for pediatric cancer survivors, as it remains one of the main causes of morbidity and mortality in this population.

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Association between Cardiac Metabolic Patterns in Oncological PET/CT and Cardiovascular Risk Factors. Contribution to the Early Investigation of Cardiotoxicity

Introduction

Takotsubo Syndrome in an Adolescent Undergoing Oncological Treatment: A Rare Case Report

Introduction

A Rare Cause and Management of Ventricular Fibrillation: 5-Fluorouracil Toxicity

Introduction

Cardio-Protection Against Cancer Treatment-Related Cardiac Dysfunction: Who is at Risk?

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