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  2. Keyword: Stem Cells
ABC
Editorial

Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?

Leonardo Rufino Garcia et al. André Monti Garzesi Flávio de Souza Brito Marcello Laneza Felicio Matheus Bertanha

Cardiovascular diseases are currently the main causes of morbidity and mortality in Brazil and worldwide., Its treatment is multimodal and has as one of its targets the fight against the progression of its major pathophysiological substrate, atherosclerosis. Lifestyle changes, prescription and use of antiplatelet agents, anticoagulants, and hypolipidemic agents, treatment of comorbidities such as systemic arterial hypertension and diabetes mellitus, and even revascularization of target organs lato sensu are important in controlling its clinical evolution.

However, many patients still have an unfavorable evolution of atherosclerosis with only clinical management and become candidates for revascularization procedures. Thus, the availability of vascular substitutes for use as grafts is essential, which can be autologous or synthetic (artificial). In turn, endovascular techniques with stents can be used to treat stenoses or occlusions according to specific clinical indications.

[…]

  • Biocompatible Materials
  • Blood Vessels
  • Cardiovascular Diseases
  • Cell Nucleous (Scaffold
  • Mortality
  • Stem Cells
  • Tissue Engineering, Bioengineering/trends
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Creative Commons Attribution (CC BY) Creative Commons license
30/06/2023 DOI: 10.36660/abc.20230341 Views 1
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ABC
Original Article

Effects of Different Types of Exercise Training on Endothelial Function in Prehypertensive and Hypertensive Individuals: A Systematic Review

Gustavo Waclawovsky et al. Marinei L. Pedralli Bruna Eibel Maximiliano I. Schaun Alexandre M. Lehnen

Abstract

Background:

Sustained high blood pressure can lead to vascular remodeling and endothelial cell injury, which may explain the endothelial dysfunction found in hypertensive individuals. Exercise training can improve vascular health in individuals with cardiovascular risk, but little is known about its effects in prehypertensive and hypertensive individuals.

Objective:

To review the literature showing evidence of changes in endothelial function in response to different modalities of exercise training in prehypertensive and hypertensive individuals.

Methods:

We conducted a systematic review of studies in the MEDLINE, Cochrane, LILACS, EMBASE, and SciELO databases following both the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and the PICO framework (patient/population, intervention, comparison and outcomes). Randomized clinical trials (RCTs) published up to April 2019 were selected and assessed by four independent reviewers. The methodological quality was assessed using the PEDro (Physiotherapy Evidence Database) scale.

Results:

Our search yielded 598 abstracts, and 10 studies were eligible for review. All of them had acceptable methodological quality by PEDro scale. Of the 10 studies, 7 involved aerobic training, 1 isometric resistance training, and 2 aerobic training and dynamic resistance training separately. Seven studies used flow-mediated dilation (FMD) to assess the vascular health, and three used plethysmography. Most training protocols involved hypertensive individuals and consisted of low and moderate-intensity exercise.

Conclusion:

Our systematic review showed that moderate continuous aerobic training is effective to improve vascular health in hypertensive individuals. In prehypertensive individuals, vigorous interval aerobic training seems to be an alternative to determine vascular health benefits. Resistance exercise training, either isometric or dynamic, can be used as a secondary alternative, but still requires further investigation.

  • Endothelium
  • Exercise
  • Hypertension
  • Resistance Training
  • Review
  • Stem Cells
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17/05/2021 DOI: 10.36660/abc.20190807 Views 1
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Original Article

Autologous Transplantation of Bone Marrow Adult Stem Cells for the Treatment of Idiopathic Dilated Cardiomyopathy

Ricardo João Westphal et al. Ronaldo Rocha Loures Bueno Paulo Bezerra de Araújo Galvão José Zanis Neto … Juliano Mendes Souza Ênio Eduardo Guérios Alexandra Cristina Senegaglia Paulo Roberto Brofman Ricardo Pasquini Claudio Leinig Pereira da Cunha

Background:

Morbimortality in patients with dilated idiopathic cardiomyopathy is high, even under optimal medical treatment. Autologous infusion of bone marrow adult stem cells has shown promising preliminary results in these patients.

Objective:

Determine the effectiveness of autologous transplantation of bone marrow adult stem cells on systolic and diastolic left ventricular function, and on the degree of mitral regurgitation in patients with dilated idiopathic cardiomyopathy in functional classes NYHA II and III.

Methods:

We administered 4,54 x 108 ± 0,89 x 108 bone marrow adult stem cells into the coronary arteries of 24 patients with dilated idiopathic cardiomyopathy in functional classes NYHA II and III. Changes in functional class, systolic and diastolic left ventricular function and degree of mitral regurgitation were assessed after 3 months, 6 months and 1 year.

Results:

During follow-up, six patients (25%) improved functional class and eight (33.3%) kept stable. Left ventricular ejection fraction improved 8.9%, 9.7% e 13.6%, after 3, 6 and 12 months (p = 0.024; 0.017 and 0.018), respectively. There were no significant changes neither in diastolic left ventricular function nor in mitral regurgitation degree. A combined cardiac resynchronization and implantable cardioversion defibrillation was implanted in two patients (8.3%). Four patients (16.6%) had sudden death and four patients died due to terminal cardiac failure. Average survival of these eight patients was 2.6 years.

Conclusion:

Intracoronary infusion of bone marrow adult stem cells was associated with an improvement or stabilization of functional class and an improvement in left ventricular ejection fraction, suggesting the efficacy of this intervention. There were no significant changes neither in left ventricular diastolic function nor in the degree of mitral regurgitation.

  • Cardiomyopathy, Dilated
  • Stem Cells
  • transplantation, autologous
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04/11/2014 DOI: 10.5935/abc.20140164
Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy
ABC
Artigo Original

Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy

Ticiana Ferreira Larocca et al. Bruno Solano de Freitas Souza Cristina Aragão Silva Carla Martins Kaneto … Adriano Costa de Alcantara Carine Machado Azevedo Murilo Fagundes Castro Simone Garcia Macambira Milena Botelho Pereira Soares Ricardo Ribeiro-dos-Santos

BACKGROUND: Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. Tissue therapy has been investigated as a possible therapeutic option for patients with cardiovascular disease. OBJECTIVE: This study evaluated the effects of therapy with mesenchymal stem cells in an experimental model of chronic Chagasic cardiomyopathy. METHODS: C57BL/6 mice were infected with 1000 trypomastigotes from the Colombian strain of T. cruzi and, after six months of infection, were treated with mesenchymal human stem cells from adipose tissue (STAT) or with Dulbecco/Vogt modified Eagle’s minimal essential medium – DMEM (control). The treated group received two intraperitoneal injections of STAT (1×10(6) cells/dose), with a month interval between the two doses. Before and after the first and second months of treatment, the chagasic and normal control animals underwent cardiopulmonary exercise testing and electrocardiography. All animals were sacrificed under anesthesia after two months of treatment for histopathological analysis of the heart. RESULTS: No improvement was observed in arrhythmias and cardiovascular function in the group of animals treated with STAT; however, sections of mice hearts in this group revealed a significant reduction in the number of inflammatory cells (p<0.0001) and areas of fibrosis (p<0.01) in comparison with chagasic animals treated with DMEM. CONCLUSION: Thus, it is concluded that administration of intraperitoneal STAT can reduce inflammation and fibrosis in the heart of mice chronically infected with T. cruzi; however, there were no effects on the cardiac function two months after transplantation.

  • Adipose Tissue
  • Chagas Cardiomyopathy
  • Stem Cells
  • tissue therapy
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09/04/2013 DOI: 10.5935/abc.20130058
Bone marrow cell transplantation in chagas' disease heart failure: report of the first human experience
ABC
Artigo Original

Bone marrow cell transplantation in chagas' disease heart failure: report of the first human experience

Fábio Vilas-Boas et al. Gilson Soares Feitosa Milena B. P. Soares Jole Alves Pinho-Filho … Augusto C. A. Mota Augusto José Gonçalves Almeida Marcus Vinícius Andrade Heitor Ghissoni Carvalho Adriano Dourado Oliveira Ricardo Ribeiro-dos-Santos

BACKGROUND: Heart failure due to Chagas’ disease (HFCD) is a progressive inflammatory cardiomyopathy that affects millions of individuals in Latin America. Studies using mice models of HFCD indicate that bone marrow mononuclear cell transplantation (BMCT) may reduce inflammation, fibrosis, and improve myocardial function. OBJECTIVE: The purpose of this study was to evaluate, for the first time in humans, the safety and efficacy of BMCT to the myocardium of patients with HFCD. METHODS: A total of 28 HFCD patients (mean age 52.2 ± 9.9 years) with NYHA class III and IV were submitted to BMCT through intracoronary injection. Effects on the left ventricle ejection fraction (LVEF), functional capacity, quality-of-life, arrhythmias, biochemical, immunological, and neuro-humoral parameters, were evaluated. RESULTS: There were no complications directly related to the procedure. LVEF was 20.1 ± 6.8% and 28.3 ± 7.9%, p < 0.03 at baseline and 180 days after the procedure, respectively. In the same period, significant improvements were observed in the NYHA class (3.1 ± 0.3 to 1.8 ± 0.5; p < 0.001), quality-of-life (50.9 ± 11.7 to 25.1 ± 15.9; p < 0.001), and in the six-minute walking test (355 ± 136 m to 437 ± 94 m; p < 0,01). There were no changes in markers of immune or neurohormonal activation. No complications were registered. CONCLUSION: Our data suggest that the intracoronary injection of BMCT is safe and potentially effective in patients with HFCD. The extent of the benefit, however, appears to be small and needs to be confirmed in a larger randomized, double blind, placebo controlled clinical trial.

  • Cardiomyopathy, Dilated
  • Chagas disease
  • Heart Failure
  • Stem Cells
  • tissue therapy
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04/03/2011 DOI: 10.1590/S0066-782X2011005000028 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Garcia LR, Garzesi AM, Brito FS, Felicio ML, Bertanha M. Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?. Arquivos Brasileiros de Cardiologia 2023;120(6):e20230341.

Electronic Document Format (ABNT)

Garcia, Leonardo Rufino; Garzesi, André Monti; Brito, Flávio de Souza; Felicio, Marcello Laneza; Bertanha, Matheus. Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?. Arquivos Brasileiros de Cardiologia, v. 120, n. 6, e20230341, Jun. 2023.

Electronic Document Format (APA)

Garcia, L. R., Garzesi, A. M., Brito, F. S., Felicio, M. L., & Bertanha, M. (2023). Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?. Arquivos Brasileiros de Cardiologia, 120(6), e20230341.

Electronic Document Format (ISO)

Garcia, Leonardo Rufino and Garzesi, André Monti and Brito, Flávio de Souza and Felicio, Marcello Laneza and Bertanha, Matheus. Scaffolds for Use in Blood Vessel Bioengineering: What are the Prospects?. Arquivos Brasileiros de Cardiologia [online]. 2023, vol. 120, n. 6, [cited 2026-10-14], e20230341. Available from: <https://journals.cardiol.br/en/article/scaffolds-for-use-in-blood-vessel-bioengineering-what-are-the-prospects/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Waclawovsky G, Pedralli ML, Eibel B, Schaun MI, Lehnen AM. Effects of Different Types of Exercise Training on Endothelial Function in Prehypertensive and Hypertensive Individuals: A Systematic Review. Arquivos Brasileiros de Cardiologia 2021;116(5):938-47.

Electronic Document Format (ABNT)

Waclawovsky, Gustavo; Pedralli, Marinei L.; Eibel, Bruna; Schaun, Maximiliano I.; Lehnen, Alexandre M.. Effects of Different Types of Exercise Training on Endothelial Function in Prehypertensive and Hypertensive Individuals: A Systematic Review. Arquivos Brasileiros de Cardiologia, v. 116, n. 5, p. 938-947, May. 2021.

Electronic Document Format (APA)

Waclawovsky, G., Pedralli, M. L., Eibel, B., Schaun, M. I., & Lehnen, A. M. (2021). Effects of Different Types of Exercise Training on Endothelial Function in Prehypertensive and Hypertensive Individuals: A Systematic Review. Arquivos Brasileiros de Cardiologia, 116(5), 938-947.

Electronic Document Format (ISO)

Waclawovsky, Gustavo and Pedralli, Marinei L. and Eibel, Bruna and Schaun, Maximiliano I. and Lehnen, Alexandre M.. Effects of Different Types of Exercise Training on Endothelial Function in Prehypertensive and Hypertensive Individuals: A Systematic Review. Arquivos Brasileiros de Cardiologia [online]. 2021, vol. 116, n. 5, [cited 2026-10-14], pp. 938-947. Available from: <https://journals.cardiol.br/en/article/effects-of-different-types-of-exercise-training-on-endothelial-function-in-prehypertensive-and-hypertensive-individuals-a-systematic-review/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Westphal RJ, Bueno RRL, Galvão PBA, Zanis Neto J, Souza JM, Guérios E, Senegaglia AC, et al. Autologous Transplantation of Bone Marrow Adult Stem Cells for the Treatment of Idiopathic Dilated Cardiomyopathy. Arquivos Brasileiros de Cardiologia 2014;103(6):521-9.

Electronic Document Format (ABNT)

Westphal, Ricardo João; Bueno, Ronaldo Rocha Loures; Galvão, Paulo Bezerra de Araújo; Zanis Neto, José; Souza, Juliano Mendes; Guérios, Ênio Eduardo; Senegaglia, Alexandra Cristina; Brofman, Paulo Roberto; Pasquini, Ricardo; Cunha, Claudio Leinig Pereira da. Autologous Transplantation of Bone Marrow Adult Stem Cells for the Treatment of Idiopathic Dilated Cardiomyopathy. Arquivos Brasileiros de Cardiologia, v. 103, n. 6, p. 521-529, Nov. 2014.

Electronic Document Format (APA)

Westphal, R. J., Bueno, R. R. L., Galvão, P. B. A., Zanis Neto, J., Souza, J. M., Guérios, E., Senegaglia, A. C., Brofman, P. R., Pasquini, R., & Cunha, C. L. P. (2014). Autologous Transplantation of Bone Marrow Adult Stem Cells for the Treatment of Idiopathic Dilated Cardiomyopathy. Arquivos Brasileiros de Cardiologia, 103(6), 521-529.

Electronic Document Format (ISO)

Westphal, Ricardo João and Bueno, Ronaldo Rocha Loures and Galvão, Paulo Bezerra de Araújo and Zanis Neto, José and Souza, Juliano Mendes and Guérios, Ênio Eduardo and Senegaglia, Alexandra Cristina and Brofman, Paulo Roberto and Pasquini, Ricardo and Cunha, Claudio Leinig Pereira da. Autologous Transplantation of Bone Marrow Adult Stem Cells for the Treatment of Idiopathic Dilated Cardiomyopathy. Arquivos Brasileiros de Cardiologia [online]. 2014, vol. 103, n. 6, [cited 2026-10-14], pp. 521-529. Available from: <https://journals.cardiol.br/en/article/autologous-transplantation-of-bone-marrow-adult-stem-cells-for-the-treatment-of-idiopathic-dilated-cardiomyopathy/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Larocca TF, Souza BSF, Silva CA, Kaneto CM, Alcantara AC, Azevedo CM, Castro MF, et al. Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy. Arquivos Brasileiros de Cardiologia 2013;100(5):460-8.

Electronic Document Format (ABNT)

Larocca, Ticiana Ferreira; Souza, Bruno Solano de Freitas; Silva, Cristina Aragão; Kaneto, Carla Martins; Alcantara, Adriano Costa de; Azevedo, Carine Machado; Castro, Murilo Fagundes; Macambira, Simone Garcia; Soares, Milena Botelho Pereira; Ribeiro-dos-Santos, Ricardo. Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy. Arquivos Brasileiros de Cardiologia, v. 100, n. 5, p. 460-468, Apr. 2013.

Electronic Document Format (APA)

Larocca, T. F., Souza, B. S. F., Silva, C. A., Kaneto, C. M., Alcantara, A. C. , Azevedo, C. M., Castro, M. F., Macambira, S. G., Soares, M. B. P., & Ribeiro-dos-Santos, R. (2013). Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy. Arquivos Brasileiros de Cardiologia, 100(5), 460-468.

Electronic Document Format (ISO)

Larocca, Ticiana Ferreira and Souza, Bruno Solano de Freitas and Silva, Cristina Aragão and Kaneto, Carla Martins and Alcantara, Adriano Costa de and Azevedo, Carine Machado and Castro, Murilo Fagundes and Macambira, Simone Garcia and Soares, Milena Botelho Pereira and Ribeiro-dos-Santos, Ricardo. Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy. Arquivos Brasileiros de Cardiologia [online]. 2013, vol. 100, n. 5, [cited 2026-10-14], pp. 460-468. Available from: <https://journals.cardiol.br/en/article/transplantation-of-adipose-tissue-mesenchymal-stem-cells-in-experimental-chronic-chagasic-cardiopathy/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Vilas-Boas F, Feitosa GS, Soares MBP, Pinho-Filho JA, Mota ACA, Almeida AJG, Andrade MV, et al. Bone marrow cell transplantation in chagas’ disease heart failure: report of the first human experience. Arquivos Brasileiros de Cardiologia 2011;96(4):325-31.

Electronic Document Format (ABNT)

Vilas-Boas, Fábio; Feitosa, Gilson Soares; Soares, Milena B. P.; Pinho-Filho, Jole Alves; Mota, Augusto C. A.; Almeida, Augusto José Gonçalves; Andrade, Marcus Vinícius; Carvalho, Heitor Ghissoni; Oliveira, Adriano Dourado; Ribeiro-dos-Santos, Ricardo. Bone marrow cell transplantation in chagas’ disease heart failure: report of the first human experience. Arquivos Brasileiros de Cardiologia, v. 96, n. 4, p. 325-331, Mar. 2011.

Electronic Document Format (APA)

Vilas-Boas, F., Feitosa, G. S., Soares, M. B. P., Pinho-Filho, J. A., Mota, A. C. A., Almeida, A. J. G., Andrade, M. V., Carvalho, H. G., Oliveira, A. D., & Ribeiro-dos-Santos, R. (2011). Bone marrow cell transplantation in chagas’ disease heart failure: report of the first human experience. Arquivos Brasileiros de Cardiologia, 96(4), 325-331.

Electronic Document Format (ISO)

Vilas-Boas, Fábio and Feitosa, Gilson Soares and Soares, Milena B. P. and Pinho-Filho, Jole Alves and Mota, Augusto C. A. and Almeida, Augusto José Gonçalves and Andrade, Marcus Vinícius and Carvalho, Heitor Ghissoni and Oliveira, Adriano Dourado and Ribeiro-dos-Santos, Ricardo. Bone marrow cell transplantation in chagas’ disease heart failure: report of the first human experience. Arquivos Brasileiros de Cardiologia [online]. 2011, vol. 96, n. 4, [cited 2026-10-14], pp. 325-331. Available from: <https://journals.cardiol.br/en/article/bone-marrow-cell-transplantation-in-chagas-disease-heart-failure-report-of-the-first-human-experience/>. ISSN 0066-782X

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