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  2. Keyword: Atherosclerosis / complications
Figure 1
IJCS
Original Article

Atherosclerosis Complications in the Brazilian Population: An Ecological Time Series Study

Emerson de Jesus Silva et al. Francieudo da Silva Gomes Junior João Vitor Bezerra Firmiano Nilson Roberto da Silva … Wendel Aguiar Carlini Marcello Barbosa Otoni Gonçalves Guedes Matheus Rodrigues Lopes Johnnatas Mikael Lopes

Abstract

Background:

Atherosclerosis is a serious health problem, and several factors contribute to its occurrence. Longitudinal and qualified monitoring of primary health care (PHC) may contribute to the management of atherosclerosis and reduction of avoidable hospital admissions.

Objectives:

To estimate the trend in hospitalizations for atherosclerosis and the impact of PHC coverage on its evolution from 2008 to 2018 in Brazil.

Methods:

An ecological time series analytical study based on the outcomes of hospital admissions for atherosclerosis in Brazil. Time in years, PHC coverage, and Family Health Strategy (FHS) services were considered independent variables. A Prais–Winsten model was used to estimate the outcome trend, and α < 0.05 was adopted.

Results:

We observed a mean increase of 1.81 hospitalizations for atherosclerosis per 100 000 inhabitants annually (p = 0.002) in Brazil. This growth was evidenced in the Northeast (p < 0.001), Southeast (p = 0.003), and South (p < 0.001) regions, being stable in the North (p = 0.057) and Midwest (p = 0.62) regions. Men presented twice the growth in hospitalizations from the fifth decade of life on (p < 0.01). An inversely proportional relationship was observed for PHC coverage (B = -0.71; p < 0.001) and the proportion of FHS services (B = -0.59; p < 0.001) with the rate of admissions due to atherosclerosis in Brazil.

Conclusions:

Although hospitalizations for atherosclerotic complications are increasing in Brazil, they present regional and individual gender and age discrepancies, as well as a mitigating effect exerted by PHC coverage.

  • Atherosclerosis / complications
  • Brazil / epidemiology
  • Ecology
  • Ecosystem
  • Environmental Health
  • population
  • Time Series Studies
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Creative Commons Attribution (CC BY) Creative Commons license
09/03/2022 DOI: 10.36660/ijcs.20210117 Views 1
Figure 1
IJCS
Viewpoint

Association between Periodontitis and Myocardial Infarction: Systematic Review and Meta-Analysis

Luiz Carlos Bodanese et al. Gabriel Campos Louzeiro Gabriela Agne Magnus Ângela Hamann Baptista … Fernanda Gonçalves Salum Rita Mattiello

Abstract

The association between periodontitis and myocardial infarction remains unclear in the literature. Few studies have addressed periodontitis exposure as a predisposing factor for the development of myocardial infarction. Therefore, the present systematic review aims to analyze the association between periodontitis and myocardial infarction. This meta-analysis systematically searched MEDLINE, EMBASE, The Cochrane Controlled Trials Register, SCIELO, LILACS, CINAHL, Scopus, Web of Science and grey literature for studies estimating the association between periodontitis and myocardial infarction. Quality of evidence was assessed for all studies. The meta-analysis was conducted using random-effects models. Four of the six studies selected were included in the meta-analysis, including 1,035,703 subjects. The association between periodontitis and myocardial infarction was: RR: 5.99 (95% CI: 1.17-30.68), but with high heterogeneity (I2 = 100%; p <0.01). The results including only the highest quality articles, was lower: RR: 2.62 (95% CI: 1.47-4.70 3.83), but with lower heterogeneity (I2 = 85.5%; p < 0.01).The present systematic review with meta-analysis showed an association between periodontitis and acute myocardial infarction, but with a high level of heterogeneity.

  • Atherosclerosis / complications
  • Atherosclerosis/complications Lipoproteins/analysis
  • Cardiovascular Diseases, mortality
  • Inflammation
  • Meta-Analysis
  • Periodontitis/complications
  • Pulpitis, Myocardial Infarction/complications
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Creative Commons Attribution (CC BY) Creative Commons license
26/05/2021 DOI: 10.36660/ijcs.20200055 Views 1
Figure 1
ABC
Original Article

Frequency of Subclinical Atherosclerosis in Brazilian HIV-Infected Patients

Péricles Sidnei Salmazo et al. Silméia Garcia Zanati Bazan Flávio Gobbis Shiraishi Rodrigo Bazan … Katashi Okoshi João Carlos Hueb

Abstract

Background:

AIDS as well as atherosclerosis are important public health problems. The longer survival among HIV-infected is associated with increased number of cardiovascular events in this population, and this association is not fully understood.

Objectives:

To identify the frequency of subclinical atherosclerosis in HIV-infected patients compared to control subjects; to analyze associations between atherosclerosis and clinical and laboratory variables, cardiovascular risk factors, and the Framingham coronary heart disease risk score (FCRS).

Methods:

Prospective cross-sectional case-control study assessing the presence of subclinical atherosclerosis in 264 HIV-infected patients and 279 controls. Clinical evaluation included ultrasound examination of the carotid arteries, arterial stiffness by pulse wave velocity (PWV) and augmentation index (AIx), laboratory analysis of peripheral blood, and cardiovascular risk according to FCRS criteria. The significance level adopted in the statistical analysis was p < 0.05.

Results:

Plaques were found in 37% of the HIV group and 4% of controls (p < 0.001). Furthermore, carotid intima-media thickness was higher in the HIV group than in controls (p < 0.001). Patients with carotid plaque had higher fasting glucose, total cholesterol, low-density lipoprotein cholesterol, and triglycerides than those without plaques. The presence of HIV, adjusted for age, overweight/obesity, and smoking increased by almost fivefold the risk of atherosclerotic carotid plaque (OR: 4.9; 95%CI: 2.5-9.9; p < 0.001). Exposure to protease inhibitors did not influence carotid intima-media thickness, was not associated with carotid plaque frequency, and did not alter the mechanical characteristics of the arterial system (PWV and AIx).

Conclusions:

HIV-infected patients are at increased risk of atherosclerosis in association with classical cardiovascular risk factors. Treatment with protease inhibitors does not promote functional changes in the arteries, and shows no association with increased frequency of atherosclerotic plaques in carotid arteries. The FCRS may be inappropriate for this population.

  • Atherosclerosis / complications
  • Cardiovascular Diseases, mortality
  • Carotid Intima Media-Carotideo
  • HIV
  • Risk Factors
  • Vascular Stiffness
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Creative Commons Attribution (CC BY) Creative Commons license
09/04/2018 DOI: 10.5935/abc.20180058 Views 1
Figure 1
ABC
Original Article

Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol

Walter Masson et al. Martín Lobo Graciela Molinero Daniel Siniawski

Abstract

Background:

Subjects with levels of non-HDL-C 30 mg/dL above those of LDL-C (lipid discordance) or with high remnant cholesterol levels could have a greater residual cardiovascular risk.

Objectives:

Methods:

Primary prevention patients without diabetes or lipid-lowering therapy were included. Regardless of the LDL-C level, we define “lipid discordance” if the non-HDL-C value exceeded 30 mg/dL that of LDL-C. Remnant cholesterol was calculated as total cholesterol minus HDL-C minus LDL-C when triglycerides were < 4.0 mmol/L. Ultrasound was used to assess carotid plaque occurrence. Multiple regression logistic models were performed.

Results:

The study included 772 patients (mean age 52 ± 11 years, 66% women). The prevalence of lipid discordance was 34%. Male sex and body mass index were independently associated with discordant lipid pattern. The prevalence of carotid plaque was higher in subjects with lipid discordance (40.2% vs. 29.2, p = 0.002). The multivariate analysis showed that the discordant lipid pattern was associated with the greater probability of carotid plaque (OR 1.58, 95% CI 1.08-2.34, p = 0.02). Similarly, a significant association between calculated remnant cholesterol and carotid plaque was found.

Conclusion:

Lipid discordance and presence of a higher level of calculated remnant cholesterol are associated with subclinical atherosclerosis. Our findings could be used to improve the residual cardiovascular risk evaluation.

  • Atherosclerosis / complications
  • Carotid Arteries
  • Cholesterol, LDL
  • Cholesterol, VLDL
  • Lipoproteins, LDL
  • Plaque, Atherosclerotic
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Creative Commons Attribution (CC BY) Creative Commons license
01/06/2017 DOI: 10.5935/abc.20170069 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Silva EJ, Gomes Junior FS, Firmiano JVB, Silva NR, Carlini WA, Guedes MBOG, Lopes MR, et al. Atherosclerosis Complications in the Brazilian Population: An Ecological Time Series Study. International Journal of Cardiovascular Sciences 2022;35(2):243-52.

Electronic Document Format (ABNT)

Silva, Emerson de Jesus; Gomes Junior, Francieudo da Silva; Firmiano, João Vitor Bezerra; Silva, Nilson Roberto da; Carlini, Wendel Aguiar; Guedes, Marcello Barbosa Otoni Gonçalves; Lopes, Matheus Rodrigues; Lopes, Johnnatas Mikael. Atherosclerosis Complications in the Brazilian Population: An Ecological Time Series Study. International Journal of Cardiovascular Sciences, v. 35, n. 2, p. 243-252, Mar. 2022.

Electronic Document Format (APA)

Silva, E. J., Gomes Junior, F. S., Firmiano, J. V. B., Silva, N. R. , Carlini, W. A., Guedes, M. B. O. G., Lopes, M. R., & Lopes, J. M. (2022). Atherosclerosis Complications in the Brazilian Population: An Ecological Time Series Study. International Journal of Cardiovascular Sciences, 35(2), 243-252.

Electronic Document Format (ISO)

Silva, Emerson de Jesus and Gomes Junior, Francieudo da Silva and Firmiano, João Vitor Bezerra and Silva, Nilson Roberto da and Carlini, Wendel Aguiar and Guedes, Marcello Barbosa Otoni Gonçalves and Lopes, Matheus Rodrigues and Lopes, Johnnatas Mikael. Atherosclerosis Complications in the Brazilian Population: An Ecological Time Series Study. International Journal of Cardiovascular Sciences [online]. 2022, vol. 35, n. 2, [cited 2026-10-15], pp. 243-252. Available from: <https://journals.cardiol.br/en/article/atherosclerosis-complications-in-the-brazilian-population-an-ecological-time-series-study/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Bodanese LC, Louzeiro GC, Magnus GA, Baptista H, Salum FG, Mattiello R. Association between Periodontitis and Myocardial Infarction: Systematic Review and Meta-Analysis. International Journal of Cardiovascular Sciences 2021;34(5 Supl 1):121-7.

Electronic Document Format (ABNT)

Bodanese, Luiz Carlos; Louzeiro, Gabriel Campos; Magnus, Gabriela Agne; Baptista, Ângela Hamann; Salum, Fernanda Gonçalves; Mattiello, Rita. Association between Periodontitis and Myocardial Infarction: Systematic Review and Meta-Analysis. International Journal of Cardiovascular Sciences, v. 34, n. 5 Supl 1, p. 121-127, May. 2021.

Electronic Document Format (APA)

Bodanese, L. C., Louzeiro, G. C., Magnus, G. A., Baptista, H., Salum, F. G., & Mattiello, R. (2021). Association between Periodontitis and Myocardial Infarction: Systematic Review and Meta-Analysis. International Journal of Cardiovascular Sciences, 34(5 Supl 1), 121-127.

Electronic Document Format (ISO)

Bodanese, Luiz Carlos and Louzeiro, Gabriel Campos and Magnus, Gabriela Agne and Baptista, Ângela Hamann and Salum, Fernanda Gonçalves and Mattiello, Rita. Association between Periodontitis and Myocardial Infarction: Systematic Review and Meta-Analysis. International Journal of Cardiovascular Sciences [online]. 2021, vol. 34, n. 5 Supl 1, [cited 2026-10-15], pp. 121-127. Available from: <https://journals.cardiol.br/en/article/association-between-periodontitis-and-myocardial-infarction-systematic-review-and-meta-analysis/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Salmazo PS, Bazan SGZ, Shiraishi FG, Bazan R, Okoshi K, Hueb JC. Frequency of Subclinical Atherosclerosis in Brazilian HIV-Infected Patients. Arquivos Brasileiros de Cardiologia 2018;110(5):402-10.

Electronic Document Format (ABNT)

Salmazo, Péricles Sidnei; Bazan, Silméia Garcia Zanati; Shiraishi, Flávio Gobbis; Bazan, Rodrigo; Okoshi, Katashi; Hueb, João Carlos. Frequency of Subclinical Atherosclerosis in Brazilian HIV-Infected Patients. Arquivos Brasileiros de Cardiologia, v. 110, n. 5, p. 402-410, Apr. 2018.

Electronic Document Format (APA)

Salmazo, P. S., Bazan, S. G. Z., Shiraishi, F. G., Bazan, R., Okoshi, K., & Hueb, J. C. (2018). Frequency of Subclinical Atherosclerosis in Brazilian HIV-Infected Patients. Arquivos Brasileiros de Cardiologia, 110(5), 402-410.

Electronic Document Format (ISO)

Salmazo, Péricles Sidnei and Bazan, Silméia Garcia Zanati and Shiraishi, Flávio Gobbis and Bazan, Rodrigo and Okoshi, Katashi and Hueb, João Carlos. Frequency of Subclinical Atherosclerosis in Brazilian HIV-Infected Patients. Arquivos Brasileiros de Cardiologia [online]. 2018, vol. 110, n. 5, [cited 2026-10-15], pp. 402-410. Available from: <https://journals.cardiol.br/en/article/frequency-of-subclinical-atherosclerosis-in-brazilian-hiv-infected-patients/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Masson W, Lobo M, Molinero G, Siniawski D. Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol. Arquivos Brasileiros de Cardiologia 2017;108(6):526-32.

Electronic Document Format (ABNT)

Masson, Walter; Lobo, Martín; Molinero, Graciela; Siniawski, Daniel. Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol. Arquivos Brasileiros de Cardiologia, v. 108, n. 6, p. 526-532, May. 2017.

Electronic Document Format (APA)

Masson, W., Lobo, M., Molinero, G., & Siniawski, D. (2017). Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol. Arquivos Brasileiros de Cardiologia, 108(6), 526-532.

Electronic Document Format (ISO)

Masson, Walter and Lobo, Martín and Molinero, Graciela and Siniawski, Daniel. Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol. Arquivos Brasileiros de Cardiologia [online]. 2017, vol. 108, n. 6, [cited 2026-10-15], pp. 526-532. Available from: <https://journals.cardiol.br/en/article/discordant-lipid-pattern-and-carotid-atherosclerotic-plaque-importance-of-remnant-cholesterol/>. ISSN 0066-782X

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