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  2. Keyword: Thrombocytopenia
Figure 1
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Research Letter

Intracardiac Metastasis of Colonic Adenocarcinoma 12 Years After Primary Tumor Control and Without Any Sign of Other Metastasis: A Case Report

Isabela Galizzi Faé et al. Gabriela Zamunaro Lopes Ruiz Gustavo Palmer Irffi Robson de Souza Almeida Junior … Pedro Anjos Conceição Eduardo Belisario Falchetto Luiz Guilherme Passaglia Geraldo Brasileiro Filho Cláudio Leo Gelape Clara Rodrigues Alves de Oliveira

Introduction

Thrombus, vegetation and tumor are the main diagnoses for intracardiac masses. Malignant cardiac tumors are rare and cardiac metastasis are around 20 times more frequent than primary tumors. Cardiac metastases originate from lymphatic or blood dissemination, mediastinum direct invasion or tumoral growth inside inferior vena cava or pulmonary veins– and can lead to obstruction of the right or left outflow or inflow tract or arrhythmias. Frequently, symptoms are similar to other prevalent cardiovascular diseases, such as dyspnea, chest pain, palpitations and edema, but sometimes a cardiac mass is found out incidentally during an image exam performed for an unrelated indication. We aim to describe an uncommon case of intracardiac metastasis from colonic adenocarcinoma 12 years after the end of the primary tumor treatment.

[…]

  • adenocarcinoma
  • Carcinoembryonic Antigen
  • Colonic Neoplasms
  • Diagnostic Imaging/methods
  • Genes, Tumor Suppresor
  • Heart Neoplasms
  • Neoplasm Metastasis
  • Thrombocytopenia
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Creative Commons Attribution (CC BY) Creative Commons license
19/12/2022 DOI: 10.36660/abc.20211014 Views 2
ABC
Brief Communication

Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study

Renato De Vecchis et al. Andrea Paccone Silvia Soreca

Abstract

Low-dose edoxaban and enoxaparin sodium have been the subject of a retrospective comparison implemented with the propensity score technique in order to mitigate the effects of the differences in the basal clinical features of two cohorts and minimize the risk of bias.

Subsequently, using a Cox proportional-hazards model, the association of each type of therapy with the risk of the composite of all-cause death, stroke/transient ischemic attack, hospitalizations and major bleeding events was assessed. For this analysis, a p-value < 0.05 was considered statistically significant. Therapy with enoxaparin and liver cirrhosis as causing thrombocytopenia were associated with increased risk of the composite endpoint (enoxaparin: hazard ratio (HR): 3.31; 95% CI: 1.54 to 7.13; p = 0.0023; liver cirrhosis, HR: 1.04; 95% CI: 1.002 to 1.089; p = 0.0410). Conversely, edoxaban therapy was significantly associated with decreased risk of the composite endpoint (HR: 0.071; 95% CI: 0.013 to 0.373; p = 0.0019). Based on this retrospective analysis, edoxaban at low doses would appear as an effective and safe pharmacological tool for the prophylaxis of cardioembolic events in patients with AF and thrombocytopenia.

  • Anticoagulants
  • Atrial Fibrillation
  • Cohort Studies
  • Edoxaban
  • Enoxaparine
  • Hemorrhage
  • Heparin/therapeutic use
  • Liver Cirrhosis
  • Stroke
  • Thrombocytopenia
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23/10/2020 DOI: 10.36660/abc.20190599 Views 2
Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease
ABC
Artigo Original

Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease

Tolga Sinan Güvenç et al. Hakan Hasdemir Hatice Betül Erer Erkan İlhan … Kazım Serhan Özcan Ali Nazmi Çalık Rengin Çetin Mehmet Eren

BACKGROUND: Extent of atherosclerotic coronary artery disease in patients with stable angina has important prognostic and therapeutic implications. In current models of plaque evolution, thrombocytes play an important role in plaque growth. Mean platelet volume is a readily obtainable marker that was shown to correlate with platelet aggregability in vitro and increased values were demonstrated after acute vascular events. OBJECTIVE: In this study, we investigated the relationship of mean platelet volume and angiographic extent of coronary artery disease in patients with stable angina. METHODS: Past medical records, complete blood count and angiographic data of 267 eligible stable angina patients were reviewed. Angiographic extent of coronary artery disease was evaluated form angiographic data using Gensini score by an expert in invasive cardiology. Mean platelet volume values were obtained from complete blood counts that obtained one day before angiography. Patients were grouped as those within (n = 176) and lower than (n = 62) population-based range for mean platelet volume. Comparison between groups and correlation analysis was performed. RESULTS: There were no linear correlation between total Gensini score and mean platelet volume (p = 0.29), while total thrombocyte count was inversely correlated with mean platelet volume (p < 0.001; r = 0.41). Patients with lower than normal mean platelet volume had significantly lower Gensini score (36.73 ± 32.5 vs. 45.63 ± 32.63; p = 0.023) and three-vessel disease (18% vs. 36%; p = 0.007) compared with those mean platelet volume values within population-based ranges. CONCLUSION: Our findings show no linear relationship exists between mean platelet volume and extent of coronary artery disease, while patients with lower than normal mean platelet volume had reduced extent of coronary artery disease.

  • Coronary Angiography
  • Coronary Artery Disease
  • Thrombocytopenia
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Creative Commons Attribution (CC BY) Creative Commons license
15/04/2013 DOI: 10.5935/abc.20130041

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Faé IG, Ruiz GZL, Irffi GP, Almeida Junior RS, Conceição PA, Falchetto EB, Passaglia LG, et al. Intracardiac Metastasis of Colonic Adenocarcinoma 12 Years After Primary Tumor Control and Without Any Sign of Other Metastasis: A Case Report. Arquivos Brasileiros de Cardiologia 2022;119(6):991-5.

Electronic Document Format (ABNT)

Faé, Isabela Galizzi; Ruiz, Gabriela Zamunaro Lopes; Irffi, Gustavo Palmer; Almeida Junior, Robson de Souza; Conceição, Pedro Anjos; Falchetto, Eduardo Belisario; Passaglia, Luiz Guilherme; Brasileiro Filho, Geraldo; Gelape, Cláudio Leo; Oliveira, Clara Rodrigues Alves de. Intracardiac Metastasis of Colonic Adenocarcinoma 12 Years After Primary Tumor Control and Without Any Sign of Other Metastasis: A Case Report. Arquivos Brasileiros de Cardiologia, v. 119, n. 6, p. 991-995, Dec. 2022.

Electronic Document Format (APA)

Faé, I. G., Ruiz, G. Z. L., Irffi, G. P., Almeida Junior, R. S., Conceição, P. A., Falchetto, E. B., Passaglia, L. G., Brasileiro Filho, G., Gelape, C. L., & Oliveira, C. R. A. (2022). Intracardiac Metastasis of Colonic Adenocarcinoma 12 Years After Primary Tumor Control and Without Any Sign of Other Metastasis: A Case Report. Arquivos Brasileiros de Cardiologia, 119(6), 991-995.

Electronic Document Format (ISO)

Faé, Isabela Galizzi and Ruiz, Gabriela Zamunaro Lopes and Irffi, Gustavo Palmer and Almeida Junior, Robson de Souza and Conceição, Pedro Anjos and Falchetto, Eduardo Belisario and Passaglia, Luiz Guilherme and Brasileiro Filho, Geraldo and Gelape, Cláudio Leo and Oliveira, Clara Rodrigues Alves de. Intracardiac Metastasis of Colonic Adenocarcinoma 12 Years After Primary Tumor Control and Without Any Sign of Other Metastasis: A Case Report. Arquivos Brasileiros de Cardiologia [online]. 2022, vol. 119, n. 6, [cited 2026-10-14], pp. 991-995. Available from: <https://journals.cardiol.br/en/article/intracardiac-metastasis-of-colonic-adenocarcinoma-12-years-after-primary-tumor-control-and-without-any-sign-of-other-metastasis-a-case-report/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Vecchis RD, Paccone A, Soreca S. Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study. Arquivos Brasileiros de Cardiologia 2020;115(4):717-8.

Electronic Document Format (ABNT)

Vecchis, Renato De; Paccone, Andrea; Soreca, Silvia. Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study. Arquivos Brasileiros de Cardiologia, v. 115, n. 4, p. 717-718, Oct. 2020.

Electronic Document Format (APA)

Vecchis, R. D., Paccone, A., & Soreca, S. (2020). Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study. Arquivos Brasileiros de Cardiologia, 115(4), 717-718.

Electronic Document Format (ISO)

Vecchis, Renato De and Paccone, Andrea and Soreca, Silvia. Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study. Arquivos Brasileiros de Cardiologia [online]. 2020, vol. 115, n. 4, [cited 2026-10-14], pp. 717-718. Available from: <https://journals.cardiol.br/en/article/thrombocytopenia-related-problems-in-patients-with-concomitant-atrial-fibrillation-requiring-antithrombotic-prevention-a-retrospective-cohort-study/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Güvenç TS, Hasdemir H, Erer HB, İlhan E, Özcan KS, Çalık AN, Çetin R, et al. Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease. Arquivos Brasileiros de Cardiologia 2013;100(3):255-60.

Electronic Document Format (ABNT)

Güvenç, Tolga Sinan; Hasdemir, Hakan; Erer, Hatice Betül; İlhan, Erkan; Özcan, Kazım Serhan; Çalık, Ali Nazmi; Çetin, Rengin; Eren, Mehmet. Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease. Arquivos Brasileiros de Cardiologia, v. 100, n. 3, p. 255-260, Apr. 2013.

Electronic Document Format (APA)

Güvenç, T. S., Hasdemir, H., Erer, H. B., İlhan, E., Özcan, K. S., Çalık, A. N., Çetin, R., & Eren, M. (2013). Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease. Arquivos Brasileiros de Cardiologia, 100(3), 255-260.

Electronic Document Format (ISO)

Güvenç, Tolga Sinan and Hasdemir, Hakan and Erer, Hatice Betül and İlhan, Erkan and Özcan, Kazım Serhan and Çalık, Ali Nazmi and Çetin, Rengin and Eren, Mehmet. Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease. Arquivos Brasileiros de Cardiologia [online]. 2013, vol. 100, n. 3, [cited 2026-10-14], pp. 255-260. Available from: <https://journals.cardiol.br/en/article/lower-than-normal-mean-platelet-volume-is-associated-with-reduced-extent-of-coronary-artery-disease/>. ISSN 0066-782X

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