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Management of Chronic Coronary Syndromes in Resource-Constrained Settings in India: An Expert Opinion With a Proposed Algorithm
IJCS
Review Article

Management of Chronic Coronary Syndromes in Resource-Constrained Settings in India: An Expert Opinion With a Proposed Algorithm

Vijay Shah et al. Saumitra Ray Devanu Ghosh Roy Samir Kubba … Sarita Rao Jabir Abdullakutty K. P. Suresh Kumar

Abstract

Cardiovascular diseases (CVDs) are associated with considerable morbidity and mortality across the world. The global financial burden caused by CVD emphasizes the importance of preventive strategies and appropriate management. Chronic coronary syndrome (CCS) is a new term recently introduced for stable coronary artery disease (CAD), which is associated with the highest cause-specific mortality in the Indian population. CCS adversely affects the quality of life (QoL) due to anxiety, fatigue, and prolonged disease course. Risk factor modification, adaptation to lifestyle changes, and pharmacotherapy are the optimal treatment options for CCS. Despite the guidelines proposed by numerous groups and societies, such as the European Society of Cardiology (ESC), the American College of Cardiology/American Heart Association (ACC/AHA), and the Taiwan Society of Cardiology, managing CCS in resource-limited situations remains challenging. Lack of awareness about CCS among patients and healthcare professionals (HCPs), limited resources, accessibility and affordability of lifesaving therapies, poor transport facilities for patients, and asymmetrical distribution are among the challenges identified. In India, the scenario of CCS is no different in rural areas and among urban poor populations due to resource constraints. The current expert opinion review based on 48 experts in the field of cardiology from eastern, western, northern, southern, and pan-India regions highlights the management of CCS in resource-constrained settings with a focus on diagnostic modalities, risk stratification, referral pathways, and medical management. Based on expert opinions and a thorough literature search, an algorithm for the management of patients with CCS in resource-constrained settings in India is also proposed.

  • Algorithms
  • Coronary Disease
  • Disease management
  • India
  • Resource-Limited Settings
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Creative Commons Attribution (CC BY) Creative Commons license
10/02/2025 DOI: 10.36660/ijcs.20240103 Views 1
ABC
Artigo Original

Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India

Debdutta Ganguli et al. Nilanjan Das Indranil Saha Krishna Rao Sanapala … Debnath Chaudhuri Saurabh Ghosh Sanjit Dey

BACKGROUND: Recent research has focused on the use of inflammatory biomarkers in the prediction of cardiovascular risk. However, information is scant regarding the association between these inflammatory markers with other cardiovascular risk factors in Asian Indians, particularly in women. OBJECTIVE: To explore the association between inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) and white blood cell (WBC) count and cardiovascular risk factors such as overall and central adiposity, blood pressure, lipid and lipoprotein variables and fasting glucose. METHODS: We conducted a cross-sectional analysis on 100 women aged 35-80 years. Participants were selected following cluster sampling methodology from 12 different randomly selected urban wards of Kolkata Municipal Corporation. RESULTS: Hs-CRP has a significant association with body mass index (BMI) ( p < 0.001) and waist circumference (WC) (p = 0.002). Significant inverse associations were observed between high-density lipoprotein cholesterol (HDL-C) and both inflammatory markers, hs-CRP (p = 0.031) and WBC count, (p = 0.014). Apolipoprotein A1 (Apo A1) was also negatively associated with hs-CRP. WBC count has significant correlation with fasting glucose and total cholesterol (TC) /HDL-C ratio. Using logistic regression, adjusting for age, BMI (odds ratio/OR, 1.186; confidence interval/CI, 1.046-1.345; p=0.008) and WC (OR, 1.045; CI, 1.005-1.087; p=0.027) were the covariates significantly associated with hs-CRP. CONCLUSION: In the present study, risk factors like BMI, WC, and HDL-C and apo A1 show significant association with hs-CRP. WBC count was significantly correlated with HDL-C, fasting glucose, TC/HDL-C ratio in women.

  • Adiposity
  • Dyslipidemias
  • India
  • Inflammation
  • Leukocyte Count
  • reactive protein C
  • Risk Factors
  • Women
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Creative Commons Attribution (CC BY) Creative Commons license
22/12/2010 DOI: 10.1590/S0066-782X2010005000165

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Shah V, Ray S, Roy DG, Kubba S, Rao S, Abdullakutty J, Kumar KPS, et al. Management of Chronic Coronary Syndromes in Resource-Constrained Settings in India: An Expert Opinion With a Proposed Algorithm. International Journal of Cardiovascular Sciences 2025;38:e20240103.

Electronic Document Format (ABNT)

Shah, Vijay; Ray, Saumitra; Roy, Devanu Ghosh; Kubba, Samir; Rao, Sarita; Abdullakutty, Jabir; Kumar, K. P. Suresh. Management of Chronic Coronary Syndromes in Resource-Constrained Settings in India: An Expert Opinion With a Proposed Algorithm. International Journal of Cardiovascular Sciences, v. 38, e20240103, Feb. 2025.

Electronic Document Format (APA)

Shah, V., Ray, S., Roy, D. G., Kubba, S., Rao, S., Abdullakutty, J., & Kumar, K. P. S. (2025). Management of Chronic Coronary Syndromes in Resource-Constrained Settings in India: An Expert Opinion With a Proposed Algorithm. International Journal of Cardiovascular Sciences, 38, e20240103.

Electronic Document Format (ISO)

Shah, Vijay and Ray, Saumitra and Roy, Devanu Ghosh and Kubba, Samir and Rao, Sarita and Abdullakutty, Jabir and Kumar, K. P. Suresh. Management of Chronic Coronary Syndromes in Resource-Constrained Settings in India: An Expert Opinion With a Proposed Algorithm. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [cited 2026-10-14], e20240103. Available from: <https://journals.cardiol.br/en/article/management-of-chronic-coronary-syndromes-in-resource-constrained-settings-in-india-an-expert-opinion-with-a-proposed-algorithm/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Ganguli D, Das N, Saha I, Sanapala KR, Chaudhuri D, Ghosh S, Dey S, et al. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arquivos Brasileiros de Cardiologia 2010;96(1):38-46.

Electronic Document Format (ABNT)

Ganguli, Debdutta; Das, Nilanjan; Saha, Indranil; Sanapala, Krishna Rao; Chaudhuri, Debnath; Ghosh, Saurabh; Dey, Sanjit. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arquivos Brasileiros de Cardiologia, v. 96, n. 1, p. 38-46, Dec. 2010.

Electronic Document Format (APA)

Ganguli, D., Das, N., Saha, I., Sanapala, K. R., Chaudhuri, D., Ghosh, S., & Dey, S. (2010). Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arquivos Brasileiros de Cardiologia, 96(1), 38-46.

Electronic Document Format (ISO)

Ganguli, Debdutta and Das, Nilanjan and Saha, Indranil and Sanapala, Krishna Rao and Chaudhuri, Debnath and Ghosh, Saurabh and Dey, Sanjit. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arquivos Brasileiros de Cardiologia [online]. 2010, vol. 96, n. 1, [cited 2026-10-14], pp. 38-46. Available from: <https://journals.cardiol.br/en/article/association-between-inflammatory-markers-and-cardiovascular-risk-factors-in-women-from-kolkata-w-b-india/>. ISSN 0066-782X

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