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  2. Keyword: Arterial Pressure / physiology
ABC
Original Article

Blood Pressure and Hemodynamic Adaptations after a Training Program in Young Individuals with Down Syndrome

Bruna Barboza Seron et al. Karla Fabiana Goessler Everaldo Lambert Modesto Eloise Werle Almeida Márcia Greguol

Background:

Cardiovascular diseases affect people worldwide. Individuals with Down Syndrome (DS) have an up to sixteen-time greater risk of mortality from cardiovascular diseases.

Objective:

To evaluate the effects of aerobic and resistance exercises on blood pressure and hemodynamic variables of young individuals with DS.

Methods:

A total of 29 young individuals with DS participated in the study. They were divided into two groups: aerobic training (AT) (n = 14), and resistance training (TR) (n = 15). Their mean age was 15.7 ± 2.82 years. The training program lasted 12 weeks, and had a frequency of three times a week for AT and twice a week for RT. AT was performed in treadmill/ bicycle ergometer, at an intensity between 50%-70% of the HR reserve. RT comprised nine exercises with three sets of 12 repetition-maximum. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) and hemodynamic variables were assessed beat-to-beat using the Finometer device before/after the training program. Descriptive analysis, the Shapiro-Wilk test to check the normality of data, and the two-way ANOVA for repeated measures were used to compare pre- and post-training variables. The Pearson’s correlation coefficient was calculated to correlate hemodynamic variables. The SPSS version 18.0 was used with the significance level set at p < 0.05.

Results:

After twelve weeks of aerobic and/or resistance training, significant reductions in variables SBP, DBP and MBP were observed.

Conclusion:

This study suggests a chronic hypotensive effect of moderate aerobic and resistance exercises on young individuals with DS.

  • Adolescent
  • Arterial Pressure / physiology
  • Down Syndrome
  • Heart Defects, Congenital
  • Hemodynamic / physiology
  • Resistance Training
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Creative Commons Attribution (CC BY) Creative Commons license
14/04/2015 DOI: 10.5935/abc.20150033 Views 1
Figure 1
ABC
Original Article

Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats

Marcelo Mendonça Mota et al. Tharciano Luiz Teixeira Braga da Silva Milene Tavares Fontes André Sales Barreto … João Eliakim dos Santos Araújo Antônio Cesar Cabral de Oliveira Rogério Brandão Wichi Márcio Roberto Viana Santos

Background:

Resistance exercise effects on cardiovascular parameters are not consistent.

Objectives:

The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats.

Methods:

Wistar rats were divided into three groups: control group (n = 8); sedentary diabetic (n = 8); and trained diabetic (n = 8). Resistance exercise was carried out in a squat device for rats and consisted of three sets of ten repetitions with an intensity of 50%, three times per week, for eight weeks. Changes in vascular reactivity were evaluated in superior mesenteric artery rings.

Results:

A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency. In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group. Furthermore, a significant increase (p < 0.05) in mean arterial blood pressure was observed in the sedentary diabetic group (104.9 ± 5 to 126.7 ± 5 mmHg) as compared to that in the control group. However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group.

Conclusions:

Resistance exercise could restore endothelial function and prevent an increase in arterial blood pressure in type 1 diabetic rats.

  • Arterial Pressure / physiology
  • diabetes
  • Endothelium, vascular / physiology
  • Exercise
  • Physical Endurance
  • Rats
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Creative Commons Attribution (CC BY) Creative Commons license
27/06/2014 DOI: 10.5935/abc.20140087

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Seron BB, Goessler KF, Modesto EL, Almeida EW, Greguol M. Blood Pressure and Hemodynamic Adaptations after a Training Program in Young Individuals with Down Syndrome. Arquivos Brasileiros de Cardiologia 2015;104(6):487-91.

Electronic Document Format (ABNT)

Seron, Bruna Barboza; Goessler, Karla Fabiana; Modesto, Everaldo Lambert; Almeida, Eloise Werle; Greguol, Márcia. Blood Pressure and Hemodynamic Adaptations after a Training Program in Young Individuals with Down Syndrome. Arquivos Brasileiros de Cardiologia, v. 104, n. 6, p. 487-491, Apr. 2015.

Electronic Document Format (APA)

Seron, B. B., Goessler, K. F., Modesto, E. L., Almeida, E. W., & Greguol, M. (2015). Blood Pressure and Hemodynamic Adaptations after a Training Program in Young Individuals with Down Syndrome. Arquivos Brasileiros de Cardiologia, 104(6), 487-491.

Electronic Document Format (ISO)

Seron, Bruna Barboza and Goessler, Karla Fabiana and Modesto, Everaldo Lambert and Almeida, Eloise Werle and Greguol, Márcia. Blood Pressure and Hemodynamic Adaptations after a Training Program in Young Individuals with Down Syndrome. Arquivos Brasileiros de Cardiologia [online]. 2015, vol. 104, n. 6, [cited 2026-10-14], pp. 487-491. Available from: <https://journals.cardiol.br/en/article/blood-pressure-and-hemodynamic-adaptations-after-a-training-program-in-young-individuals-with-down-syndrome/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Mota MM, Silva TLTB, Fontes MT, Barreto AS, Araújo JES, Oliveira ACC, Wichi RB, et al. Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats. Arquivos Brasileiros de Cardiologia 2014;103(1):25-32.

Electronic Document Format (ABNT)

Mota, Marcelo Mendonça; Silva, Tharciano Luiz Teixeira Braga da; Fontes, Milene Tavares; Barreto, André Sales; Araújo, João Eliakim dos Santos; Oliveira, Antônio Cesar Cabral de; Wichi, Rogério Brandão; Santos, Márcio Roberto Viana. Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats. Arquivos Brasileiros de Cardiologia, v. 103, n. 1, p. 25-32, Jun. 2014.

Electronic Document Format (APA)

Mota, M. M., Silva, T. L. T. B. , Fontes, M. T., Barreto, A. S., Araújo, J. E. S., Oliveira, A. C. C. , Wichi, R. B., & Santos, M. R. V. (2014). Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats. Arquivos Brasileiros de Cardiologia, 103(1), 25-32.

Electronic Document Format (ISO)

Mota, Marcelo Mendonça and Silva, Tharciano Luiz Teixeira Braga da and Fontes, Milene Tavares and Barreto, André Sales and Araújo, João Eliakim dos Santos and Oliveira, Antônio Cesar Cabral de and Wichi, Rogério Brandão and Santos, Márcio Roberto Viana. Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats. Arquivos Brasileiros de Cardiologia [online]. 2014, vol. 103, n. 1, [cited 2026-10-14], pp. 25-32. Available from: <https://journals.cardiol.br/en/article/resistance-exercise-restores-endothelial-function-and-reduces-blood-pressure-in-type-1-diabetic-rats/>. ISSN 0066-782X

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