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Letter to the Editor

Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial

Carla Paixão Miranda et al. Fernando Botoni Manoel Rocha

Reply

On 09/29/21 we received notification of a Letter to the Editor of the Arquivos Brasileiros de Cardiologia journal with some criticisms to our article entitled “Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial”. We would like to thank the editors for the opportunity to respond and would like to clarify some points mentioned in the aforementioned Letter, which, according to our understanding, has serious problems in the interpretation of the scientific methodology processes used in our article.

The authors of the Letter report that a healthy control group was not added to the study. In fact, it was not and we report below the reasons why we made this methodological decision. The objective of the study was to analyze the influence of simvastatin use on the lipid profile adaptations resulting from aerobic and resistance training in aquatic environments in elderly women with dyslipidemia. Considering that the literature is already vast concerning studies of physical training interventions with a healthy population and evaluation of lipid parameters, the focus of our experiment was to study their effects on individuals with dyslipidemia, thus bringing a new result focused on those who need therapeutic interventions the most, aiming at improving the lipid profile. In this context, we did not see the justification for the inclusion of a healthy group. Another reason is the complete lack of intention to compare the effects of using a lipid-lowering medication in healthy individuals versus dyslipidemia patients. Therefore, we did not find any justification for the use of this medication in a healthy population.

[…]

  • Aquatic Environment
  • Diabetes Mellitus
  • Exercise
  • Hypertension
  • Metabolica Syndome/complications
  • Physical activity
  • Statins
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Creative Commons Attribution (CC BY) Creative Commons license
13/05/2022 DOI: 10.36660/abc.20210746 Views 2
Figure 1
ABC
Original Article

Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial

Rochelle Rocha Costa et al. Alexandra Ferreira Vieira Leandro Coconcelli Alex de Oliveira Fagundes … Adriana Cristine Koch Buttelli Laura Frances Pereira Ricardo Stein Luiz Fernando Martins Kruel

Abstract

Background:

Statin use is highlighted as the most commonly utilized therapy for the treatment of dyslipidemias and can be considered as the most efficient pharmacological intervention for low-density lipoprotein (LDL) reduction. On the other hand, physical training can be considered an efficient and safe non-pharmacological strategy to promote improvements in lipid profile. However, the influence of statins on lipid adaptations arising from water-based training in populations with dyslipidemia is not known.

Objectives:

To analyze the influence of simvastatin use on lipid adaptations arising from water-based aerobics and resistance training in elderly women with dyslipidemia.

Methods:

Sixty-nine elderly (66.13 ± 5.13 years), sedentary, and dyslipidemic women, both non-users and users of simvastatin (20 mg and 40 mg), were randomized into the following 3 groups: water-based aerobic training (WA), water-based resistance training (WR), and control group (CG). Total duration of interventions, for all experimental groups consisted of 10 weeks, with 2 weekly sessions. Biochemical analyses were performed before the beginning of the interventions and repeated after the end of the trial. Generalized estimating equations were used to compare these data, setting α = 0.05.

Results:

In intention-to-treat analysis, the medicated participants obtained a greater magnitude of decrease in total cholesterol (TC) (−3.41 to −25.89 mg.dl−1; p = 0.038), LDL (−5.58 to −25.18 mg.dl−1; p = 0.007) and TC/HDL ratio (−0.37 to −0.61; p = 0.022) when compared to the non-medicated participants, and this decrease was statistically significant only in the WR group.

Conclusions:

Statin use enhances the adaptations promoted by water-based physical training in CT, LDL levels, and CT/HDL ratio, and it is more pronounced after WR.

  • Aquatic Environment
  • Diabetes Mellitus
  • Exercise
  • hydroxymethylglutaryl-CoA reductases inhibitors
  • Hypertension
  • Metabolic Syndrome/complications
  • Obesity
  • Physical activity
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Creative Commons Attribution (CC BY) Creative Commons license
06/09/2021 DOI: 10.36660/abc.20200197 Views 2

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Miranda CP, Botoni F, Rocha M. Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia 2022;118(5):1002-4.

Electronic Document Format (ABNT)

Miranda, Carla Paixão; Botoni, Fernando; Rocha, Manoel. Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia, v. 118, n. 5, p. 1002-1004, May. 2022.

Electronic Document Format (APA)

Miranda, C. P., Botoni, F., & Rocha, M. (2022). Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia, 118(5), 1002-1004.

Electronic Document Format (ISO)

Miranda, Carla Paixão and Botoni, Fernando and Rocha, Manoel. Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia [online]. 2022, vol. 118, n. 5, [cited 2026-10-14], pp. 1002-1004. Available from: <https://journals.cardiol.br/en/article/statin-use-improves-cardiometabolic-protection-promoted-by-physical-training-in-an-aquatic-environment-a-randomized-clinical-trial/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Costa RR, Vieira AF, Coconcelli L, Fagundes AO, Buttelli ACK, Pereira LF, Stein R, et al. Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia 2021;117(2):270-8.

Electronic Document Format (ABNT)

Costa, Rochelle Rocha; Vieira, Alexandra Ferreira; Coconcelli, Leandro; Fagundes, Alex de Oliveira; Buttelli, Adriana Cristine Koch; Pereira, Laura Frances; Stein, Ricardo; Kruel, Luiz Fernando Martins. Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia, v. 117, n. 2, p. 270-278, Sep. 2021.

Electronic Document Format (APA)

Costa, R. R., Vieira, A. F., Coconcelli, L., Fagundes, A. O., Buttelli, A. C. K., Pereira, L. F., Stein, R., & Kruel, L. F. M. (2021). Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia, 117(2), 270-278.

Electronic Document Format (ISO)

Costa, Rochelle Rocha and Vieira, Alexandra Ferreira and Coconcelli, Leandro and Fagundes, Alex de Oliveira and Buttelli, Adriana Cristine Koch and Pereira, Laura Frances and Stein, Ricardo and Kruel, Luiz Fernando Martins. Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial. Arquivos Brasileiros de Cardiologia [online]. 2021, vol. 117, n. 2, [cited 2026-10-14], pp. 270-278. Available from: <https://journals.cardiol.br/en/article/statin-use-improves-cardiometabolic-protection-promoted-by-physical-training-in-an-aquatic-environment-a-randomized-clinical-trial-2/>. ISSN 0066-782X

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