Pharmacology – ABC CARDIOL

ABCHF

Review Article

Pharmacokinetics, Mechanism of Action, and Adverse Effects of the Main Drugs Used to Treat Heart Failure: A Practical Overview for the Clinical Cardiologist

Viviane Melo e Silva de Figueiredo et al. João Vitor Soares Santos Bruna Costa de Albuquerque Bogéa Amanda Gomes de Oliveira José Albuquerque de Figueiredo Neto

Angiotensin-converting enzyme inhibitors (ACEI)

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ABC

Editorial

Heroin by Dreser x Eroica by Beethoven

Claudio Pinho

As a Classical Music lover, I go to the São Paulo Concert Hall frequently. On my way to get there it’s necessary to drive through an area with high density of addicts on streets, known as Crackland. In that moment I get to see closely the important negative social effects and damage of addiction in its users. Now I meet this issue in a different way, reading the paper: “Heroin and Electrocardiography- Effect of Heroin on Electrocardiography parameters” that adds an incremental knowledge in the medical literature about heroin cardiac effects and searches for signals of when this occurs.

The authors of “Heroin and Electrocardiography- Effect of Heroin on Electrocardiography parameters” make it clear that there is little scientific information published in this field. Research in the PubMed shows a 1980 reference called “ECG examinations 115 heroin addicts” with no access to the abstract or the full-text contents. Very little was found about this specific topic since then. How can this be explained considering addiction has since then increased in alarming scale? Is there lack of interest by researchers in this area? Are there little financial resources for researchers? Logistical difficulties for studies in this field? Lack of interest in this social group?

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ABC

Artigo de Pesquisa

Pharmacology of fibrates

Hermes Toros Xavier

Fibrates are drugs commonly used in hypertriglyceridemias. After their absorption, fibrates are metabolized by the liver, using P450 isoenzymes not shared by statins. However, for some fibrates, such as genfibrozil, an interaction with statins can occur during their liver glucuronidation, or by displacement of free fraction of statins linked to proteins in plasma. Plasma half-life is variable among fibrates (2-80 h). Recently it has been shown that fibrates produce plasma lipid changes mainly by stimulating peroxisome-proliferation activation receptors alpha. Through this action, there is an increase in the transcription of some genes related to lipid metabolism, such as LLP, APOAI, APOAII, ABCA-1, as well as decrease in the expression of APOCIII, and many other actions.

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Pharmacokinetics, Mechanism of Action, and Adverse Effects of the Main Drugs Used to Treat Heart Failure: A Practical Overview for the Clinical Cardiologist

Angiotensin-converting enzyme inhibitors (ACEI)

Heroin by Dreser x Eroica by Beethoven

Pharmacology of fibrates

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Electronic Document Format (Vancouver)

Electronic Document Format (ABNT)

Electronic Document Format (APA)

Electronic Document Format (ISO)

Electronic Document Format (Vancouver)

Electronic Document Format (ABNT)

Electronic Document Format (APA)

Electronic Document Format (ISO)