Pericarditis, Constrictive

ABCIC

Case Report

Recurrent Constrictive Pericarditis after Pericardiectomy: Case Report

Eduardo Cavalcanti Lapa Santos et al. Brivaldo Markman Filho Sandro Gonçalves de Lima Andréa Bezerra de Melo da Silveira Lordsleem … Arthur Cesário Holanda Fernanda Mariz Queiroga Pedrosa

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ABC

Editorial

Galectin-3 in Chronic Constrictive Pericarditis: Accurate Information for the Good Doctor

Wolney de Andrade Martins

Galectin-3 (Gal-3), which is now known as a new biomarker, has traveled the rigorous scientific pathway from discovery to validation. Experimental and clinical studies described its elevation in several situations, such as tumors, renal failure and heart failure. Its administration caused myocardial fibrosis and heart failure (HF). Its genetic suppression or inhibition prevented fibrosis and remodeling, that is, the cause-and-effect relationship had been proven. Elevated levels of Gal-3 show a worse prognosis, as they predict sudden death. Galectin-3 was an independent predictor in the short and medium term of hospitalizations and of mortality in patients with HF, especially those with heart failure with preserved ejection fraction (HFpEF).

The biomarker can assist the clinician in their diagnostic dilemmas, in assessing the prognosis and even guiding the therapy. The HFpEF is an example of condition where all help is welcome. Multiple comorbidities, less typical conditions, especially in the elderly and obese, can be confusing. HFpEF is one of the situations where Gal-3 can greatly assist in diagnostic confirmation.

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ABC

Artigo Original

Serum NT pro-BNP: relation to systolic and diastolic function in cardiomyopathies and pericardiopathies

Charles Mady et al. Fábio Fernandes Edmundo Arteaga Felix José Alvarez Ramires … Paula de Cássia Buck Vera Maria Cury Salemi Barbara Maria Ianni Luciano Nastari Ricardo Ribeiro Dias

BACKGROUND: NT pro-BNP is a marker of systolic and diastolic dysfunction. OBJECTIVE: To determine NT pro-BNP levels in patients with chagasic, hypertrophic, and restrictive heart diseases, as well as with pericardial diseases, and their relation to echocardiographic measurements of systolic and diastolic dysfunction. METHODS: A total of 145 patients were divided into the following groups: 1) Chagas’ heart disease (CHD) – 14 patients; 2) hypertrophic cardiomyopathy (HCM) – 71 patients; 3) endomyocardial fibrosis (EMF) – 26 patients; 4) pericardial effusion (PE) – 18 patients; and 5) constrictive pericarditis (CP) – 16 patients. The control group was comprised of 40 individuals with no heart disease. The degree of myocardial impairment and pericardial effusion were assessed by two-dimensional echocardiography and the degree of restriction by pulsed Doppler transmitral flow. The diagnosis of CP was confirmed through magnetic resonance imaging. NT pro-BNP levels were determined through electrochemiluminescence immunoassay. RESULTS: NT pro-BNP was increased (p < 0.001) in CHD (median = 513.8 pg/ml), HCM (median = 848 pg/ml), EMF (median = 633 pg/ml), CP (median = 568 pg/ml), and PE (median = 124 pg/ml), when compared with the control group (median = 28 pg/ml). No statistically significant differences were found between CP and EMF (p = 0.14). In the hypertrophic group, NT pro-BNP was correlated with left atrial size (r = 0.40; p < 0.001) and with E/Ea ratio (p < 0.01). In the restrictive group, there was a trend of correlation with E-wave peak velocity (r = 0.439; p = 0.06). CONCLUSION: NT pro-BNP is increased in the different cardiomyopathies and pericardial diseases and is correlated with the degree of systolic and diastolic dysfunction.

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Recurrent Constrictive Pericarditis after Pericardiectomy: Case Report

Galectin-3 in Chronic Constrictive Pericarditis: Accurate Information for the Good Doctor

Serum NT pro-BNP: relation to systolic and diastolic function in cardiomyopathies and pericardiopathies

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