Naringin, Trimetazidine and Baroreflex in Renal Ischemia-Reperfusion Injury
The paper “Naringin and trimetazidine improve baroreflex sensitivity and electrical activity of solitary tract nucleus in renal ischemia-reperfusion injury,” published in this journal, found improvement in baroreflex sensitivity in an acute ischemia/reperfusion kidney injury model in rats treated by naringin and/or trimetazidine.
Trimetazidine and naringin are substances capable of reducing oxidative stress, documented in many situations. Trimetazidine is a drug with anti-ischemic properties, which acts directly on mitochondria and is able to decrease oxidative stress. Naringin is a polyphenol with antioxidant properties present in several citrus fruits.
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