Blood Pressure Variability and Cardiovascular Risk in ELSA-Brasil: A Potential Surrogate Marker for Predicting Mortality and Cardiovascular Outcomes?

Blood pressure (BP) homeostasis is a crucial element in the protection of cardiovascular events. Many national and international guidelines ^– have proposed target values for blood pressure, and these recommendations consider slightly different goals according to hypertension stages, risk stratification and presence of renal or cardiovascular diseases, and target organ lesion. However, these values are based on office measures, ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM), not accounting for blood pressure variability (BPV). BP intraindividual variability is an independent risk factor for cardiovascular diseases regardless of mean BP. ^– Fluctuations in physiological measures of blood pressure do not occur randomly and can contribute or be predictors of cardiovascular outcomes.

Most studies evaluated BPV on short (24h), medium (>2 days) or long-term (weekly, monthly, or annually). ^, Short-term BPV can be associated with increased cardiovascular risk. ^,

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