Systemic Immune-inflammation Index

ABC

Original Article

Predictive Value of the Systemic Immune-inflammation Index for Recurrence of Idiopathic Acute Pericarditis

Abstract

Background

Identifying patients at increased risk of recurrence of acute pericarditis remains challenging. High-sensitivity C-reactive protein (hs-CRP) can be used to predict recurrence, but it has certain limitations.

Objectives

This study aimed to evaluate the association between a novel biomarker, the Systemic Immune-Inflammation Index (SII), and the recurrence of acute pericarditis.

Methods

This retrospective cohort study included 110 patients diagnosed with acute idiopathic pericarditis, the primary endpoint of the study was to investigate Recurrent Pericarditis (RP) during the 18 month follow-up period. Patients were divided into two groups based on whether or not they developed recurrent pericarditis. Physical examination, electrocardiography, echocardiography, and laboratory test results of these patients were evaluated. P < 0.05 was considered statistically significant.

Results

The mean age of the patients was 42.8 ± 15.2 years, and 42.7% were male. The group with RP had significantly higher leukocyte counts (8.7 ± 3.2 vs. 12 ± 4.7; p = 0.001), neutrophil counts (5.4 ± 2.7 vs. 9 ± 4.5; p < 0.001), hs-CRP levels (29.1 ± 40.9 vs. 49.5 ± 62.2; p = 0.048), and neutrophil-to-lymphocyte ratio (2.9 ± 2.5 vs. 6 ± 2.8; p < 0.001). SII (783.2 ± 770.2 vs. 1664.2 ± 1086.6; p < 0.001) was also significantly higher in patients with recurrence. Both SII and hs-CRP were independently associated with recurrence (p < 0.001 and p < 0.05, respectively).

Conclusion

SII and hs-CRP were found to be independent predictors for recurrence in acute pericarditis patients during the 18 month follow-up. Similar to hs-CRP, SII may also be used as an important parameter in predicting recurrent pericarditis.

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ABC

Original Article

Inflammation Burden and Atrial Fibrillation Burden: A Bidirectional Relationship

Abdulrahman Naser et al. Samet Sayilan Oya Güven Büşra Güvendi Şengör … Atakan Biçici Yücel Uzun Ahmet Ekmekçi Alev Kılıçgedik

Abstract

Background

Atrial fibrillation (AF) burden is defined as the proportion of time the patient remains in AF over a given period of time; thus, it is theoretically highest in permanent AF and lowest in paroxysmal AF. Inflammation is associated with the initiation and maintenance of AF. However, the relationship between systemic immune-inflammation index (SII) and AF burden is unknown.

Objective

In the present study, we investigated the relationship between SII and AF burden.

Methods

The present study is a cross-sectional analysis of 453 patients (252 females and 201 males, aged 44 to 94 years) with AF (138 with paroxysmal AF and 315 with permanent AF) who visited the cardiology outpatient clinic between October 2022 and June 2023. SII was calculated as (neutrophils × platelets/lymphocytes). The predictive role of SII and other inflammatory markers in the likelihood of AF pattern was evaluated by logistic regression analyses, and p value < 0.05 was considered statistically significant.

Results

Age, diastolic blood pressure, heart rate, diabetes mellitus, neutrophil, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, SII, C-reactive protein, red blood cell distribution width, hemoglobin A1c, and left atrial diameter were significantly higher in the permanent AF group. According to the logistic regression analysis, age (p = 0.038), diabetes mellitus (p = 0.024), red blood cell distribution width (p = 0.023), C-reactive protein (p = 0.010), SII (p = 0.001), and left atrial diameter (p < 0.001) significantly contributed to the prediction of the likelihood of permanent AF.

Conclusion

SII is independently associated with the AF burden. Prospective studies are needed to determine whether SII may be useful in identifying patients at high risk for AF progression.

Read Full Article

Predictive Value of the Systemic Immune-inflammation Index for Recurrence of Idiopathic Acute Pericarditis

Abstract

Background

Objectives

Methods

Results

Conclusion

Inflammation Burden and Atrial Fibrillation Burden: A Bidirectional Relationship

Abstract

Background

Objective

Methods

Results

Conclusion

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Electronic Document Format (Vancouver)

Electronic Document Format (ABNT)

Electronic Document Format (APA)

Electronic Document Format (ISO)