Neoplasms/drug therapy

ABCIC

Review Article

Application of Echocardiography in the Early Detection of Cardiotoxicity by Chemotherapy

Rafael Carlos Castilla Fassio et al. José Maria Del Castillo

Abstract

The cardiotoxicity produced by chemotherapeutic agents, mainly to treat breast cancer, presents a significant incidence, often requiring specific treatment and / or forcing the reduction or suspension of the chemotherapeutic treatment. Cardiotoxicity is characterized by causing cell damage, reversible or not, leading to heart failure. The main indicators of these alterations can be detected by conventional echocardiography, through the left ventricular ejection fraction and techniques that evaluate myocardial deformation, such as the global longitudinal strain, which are now considered essential markers for this analysis. The cardiotoxicity produced by anthracyclines, monoclonal antibodies and their association is analyzed, the latter showing an alarming incidence, mainly in elderly patients.

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Revisão

Hypertension in Patients with Cancer

Vinicius Barbosa de Souza et al. Eduardo Nani Silva Mario Luiz Ribeiro Wolney de Andrade Martins

There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality.

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Application of Echocardiography in the Early Detection of Cardiotoxicity by Chemotherapy

Abstract

Hypertension in Patients with Cancer

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Electronic Document Format (APA)

Electronic Document Format (ISO)

Electronic Document Format (Vancouver)

Electronic Document Format (ABNT)

Electronic Document Format (APA)

Electronic Document Format (ISO)