Marcelo Diarcadia Mariano Cezar et al. Aline Regina Ruiz Lima Luana Urbano Pagan Ricardo Luiz Damatto
Arterial hypertension (AH) is frequently associated with metabolic disturbs, target-organs functional and/or structural alterations. In Brazil, it contributes, directly or indirectly, to 50% of cardiovascular disease death. AH experimental models have showed biochemical and cardiovascular alterations.–
Among the most common experimental models of AH in rats are genetic hypertension developed by Okamoto and Aoki with the spontaneous hypertension model, Dahl salt-susceptible, a result of a defect in renal excrete sodium, neurogenic hypertension, defined as a permanent increase in blood pressure resulting from a fundamentally neural (central or peripheral) change. Renal hypertension may be renoprive, produced by severe reduction in renal function, renovascular hypertension that is due to partial obstruction of blood flow to the kidneys, or in some cases both.
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