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  2. Keyword: Androgens
Figure 1
IJCS
Editorial

Anabolic-Androgenic Steroids and Cardiotoxicity

José Antônio Caldas Teixeira et al. Joelma Dominato Rocha Carvalho Mateus Freitas Teixeira

Anabolic-androgenic steroids (AAS) are a class of natural and synthetic hormones, which owe their name to their chemical structure (steroid nucleus) and their biological, anabolic, and androgenic effects. Misuse of AAS for aesthetic and performance purposes has become widespread, as they provide increases in muscle mass and strength. It is estimated that approximately 3.5% of the world’s population uses AAS.

Use of AAS dates back to ancient Greece, followed by the Second World War. They were detected in sports competitions in 1954 and later disseminated among bodybuilders and identified in various sports in the Tokyo 1964 Olympic Games. Currently, we are witnessing a growing encouragement of AAS use for aesthetic purposes, through “beauty chips” and disguised as hormone replacement therapy. This indiscriminate use culminated in a resolution by the Brazilian Federal Council of Medicine against the prescription of these hormones for aesthetic purposes.

[…]

  • Anabolic Androgenic Steroids
  • Androgens
  • Cardiotoxicity
  • Steroids
  • Testosterone
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Creative Commons Attribution (CC BY) Creative Commons license
15/08/2025 DOI: 10.36660/ijcs.20250096 Views 1
Cardiovascular risks of androgen deprivation therapy
ABC
Revisão

Cardiovascular risks of androgen deprivation therapy

Adriano Freitas Ribeiro et al. César Camara Carlos Alexandre Segre Miguel Srougi Carlos V. Serrano Jr

Prostate adenocarcinoma is the most common cancer type in the male sex after skin cancer. Among the several types of treatment for prostate cancer, the androgen deprivation therapy has been highly recommended in patients with metastatic or locally advanced disease, which probably results in increased survival. However, the androgen deprivation is the cause of several adverse effects. Complications such as osteoporosis, sexual dysfunction, gynecomastia, anemia and body composition alterations are well-known effects of the therapy. Recently, a number of metabolic complications have been described, such as increase in the abdominal circumference, insulin resistance, hyperglycemia, diabetes, dyslipidemia and metabolic syndrome, with a consequent increase in the risk of coronary events and cardiovascular mortality in this specific population. This update article presents a literature review carried out at MEDLINE database of all literature published in English from 1966 to June 2009, using the following key words: androgen deprivation therapy, androgen suppression therapy, hormone treatment, prostate cancer, metabolic syndrome and cardiovascular disease, with the objective of analyzing which would be the actual cardiovascular risks of androgen deprivation therapy, also called androgen suppression, in patients with prostate cancer.

  • Androgens
  • Cardiovascular Diseases
  • endocrine system diseases
  • Hormones
  • Risk
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Creative Commons Attribution (CC BY) Creative Commons license
13/10/2010 DOI: 10.1590/S0066-782X2010001300019 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Teixeira JAC, Carvalho JDR, Teixeira MF. Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences 2025;38:e20250096.

Electronic Document Format (ABNT)

Teixeira, José Antônio Caldas; Carvalho, Joelma Dominato Rocha; Teixeira, Mateus Freitas. Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences, v. 38, e20250096, Aug. 2025.

Electronic Document Format (APA)

Teixeira, J. A. C., Carvalho, J. D. R., & Teixeira, M. F. (2025). Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences, 38, e20250096.

Electronic Document Format (ISO)

Teixeira, José Antônio Caldas and Carvalho, Joelma Dominato Rocha and Teixeira, Mateus Freitas. Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [cited 2026-10-14], e20250096. Available from: <https://journals.cardiol.br/en/article/anabolic-androgenic-steroids-and-cardiotoxicity/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Ribeiro AF, Camara C, Segre CA, Srougi M, Serrano Jr CV. Cardiovascular risks of androgen deprivation therapy. Arquivos Brasileiros de Cardiologia 2010;95(3):412-5.

Electronic Document Format (ABNT)

Ribeiro, Adriano Freitas; Camara, César; Segre, Carlos Alexandre; Srougi, Miguel; Serrano Jr, Carlos V.. Cardiovascular risks of androgen deprivation therapy. Arquivos Brasileiros de Cardiologia, v. 95, n. 3, p. 412-415, Oct. 2010.

Electronic Document Format (APA)

Ribeiro, A. F., Camara, C., Segre, C. A., Srougi, M., & Serrano Jr, C. V. (2010). Cardiovascular risks of androgen deprivation therapy. Arquivos Brasileiros de Cardiologia, 95(3), 412-415.

Electronic Document Format (ISO)

Ribeiro, Adriano Freitas and Camara, César and Segre, Carlos Alexandre and Srougi, Miguel and Serrano Jr, Carlos V.. Cardiovascular risks of androgen deprivation therapy. Arquivos Brasileiros de Cardiologia [online]. 2010, vol. 95, n. 3, [cited 2026-10-14], pp. 412-415. Available from: <https://journals.cardiol.br/en/article/cardiovascular-risks-of-androgen-deprivation-therapy/>. ISSN 0066-782X

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