Família ABC Arquivos Brasileiros de Cardiologia International Journal of Cardiovascular Sciences ABC Heart Failure & Cardiomyopathy ABC Imagem Cardiovascular
Português English
Família ABC
Português English
  • Sobre
    • Sobre a Família ABC
    • Regimento Interno
    • Conselho Editorial
    • Sociedade Brasileira de Cardiologia (SBC)
  • Edições
  • Diretrizes da SBC
  • Conteúdos
    • Vídeos
    • Podcasts
    • Notícias
  • Sobre
    • Sobre a Família ABC
    • Regimento Interno
    • Conselho Editorial
    • Sociedade Brasileira de Cardiologia (SBC)
  • Edições
  • Diretrizes da SBC
  • Conteúdos
    • Vídeos
    • Podcasts
    • Notícias

Família ABC

  • Família ABC
  • Arquivos Brasileiros de Cardiologia
  • International Journal of Cardiovascular Sciences
  • ABC Heart Failure & Cardiomyopathy
  • ABC Imagem Cardiovascular
Buscar em

Nenhum conteúdo encontrado.

Revistas
Ordenação
Tipos de artigo
Outros

  1. Início
  2. Palavra-chave: statins
IJCS
Case Report

Acute Coronary Disease in very Young Patient: A Reality!

Erivelton Nascimento et al. Ana Luisa Freitas e Pena Mello Ludmila Souza da Cunha Marcelo Ferreira Villela

Introduction

Acute cardiovascular events such as acute myocardial infarction (AMI) are uncommon in young individuals. Additionally, it is known that different factors may be involved in the occurrence of AMI. Here, we report a case of acute myocardial infarction due to severe coronary lesion in a very young patient.

[…]

  • Artery Coronary Diseases
  • Atherosclerosis
  • Enoxaparin
  • Hereditity
  • Hyperlipidemias
  • Myocardial Infarction
  • Platelets/treatment
  • statins
  • Street Drugs
  • young
Ler artigo completo
Creative Commons Attribution (CC BY) Creative Commons license
23/11/2020 DOI: 10.36660/ijcs.20200010 Visualizações 1
ABC
Original Article

Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation

Vera Lúcia Portal et al. Emílio H. Moriguchi José Luiz da Costa Vieira Sadi Schio … Eduardo T. Mastalir Fabiana Buffé Eleni Borges Bortolini Ricardo Santalucia Brüch Rubem Rodrigues

OBJECTIVE: To study the differences between fluvastatin and pravastatin regarding LDL susceptibility to oxidation, plasma levels of total cholesterol (TC), HDL-C, LDL-C and triglycerides (TG) in hypercholesterolemic patients with established coronary heart disease (CHD). METHODS: A double-blind randomized parallel study was conducted that included 41 hypercholesterolemic outpatients with CHD treated at the Instituto de Cardiologia do Rio Grande do Sul. The inclusion criteria were LDL-C above 100 mg/dL and triglycerides below 400 mg/dL based on 2 measures. After 4 weeks on a low cholesterol diet, those patients that fullfilled the inclusion criteria were randomized into 2 groups: the fluvastatin group (fluvastatin 40 mg/day) and the pravastatin group (pravastatin 20 mg/day), for 24 weeks of treatment. LDL susceptibility to oxidation was analyzed with copper-induced production of conjugated dienes (Cu2+) and water-soluble free radical initiator azo-bis (2′-2’amidinopropanil) HCl (AAPH). Spectroscopy nuclear magnetic resonance was used for determination of lipids. RESULTS: After 24 weeks of drug therapy, fluvastatin and pravastatin significantly reduced LDL susceptibility to oxidation as demonstrated by the reduced rate of oxidation (azo and Cu) and by prolonged azo-induced lag time (azo lag). The TC, LDL-C, and TG reduced significantly and HDL-C increased significantly. No differences between the drugs were observed. CONCLUSION: In hypercholesterolemic patients with CHD, both fluvastatin and pravastatin reduced LDL susceptibility to oxidation.

  • hypercholesterolemia
  • LDL oxidation
  • statins
Ler artigo completo
Creative Commons Attribution (CC BY) Creative Commons license
02/04/2003 DOI: 10.1590/S0066-782X2003000200004
ABC
Original Article

Prescription and adherence to statins of patients with coronary artery disease and hypercholesterolemia

Antonio P. Mansur et al. André P. L. Mattar Cristiane E. Tsubo Danielle T. Simão … Fábio R. Yoshi Kuang Daci

OBJECTIVE: Statins have proved to be safe and effective in the secondary prevention of coronary artery disease, but the level of prescription and the reasons for nonadherence to treatment in many coronariopathy treatment centers has not been determined. The purpose of this study was to identify reasons for nonadherence to statin therapy. METHODS: We analyzed 207 consecutive patients with coronary artery disease and hypercholesterolemia (total cholesterol > or = 200mg/dL or LDL – cholesterol > or = 130mg/dL). Patients’ average age was 61.7±10 year; 111 (53.6%) male were and 94 (46.6%) were female. We analyzed the level of prescription and adherence to treatment with statins. RESULTS: Statins were prescribed for 139 (67%) patients, but only 85 (41%) used the drug. In spite of being indicated, statins were not prescribed in 68 (33%) patients. Of 54 (26%) patients, nonadherent to statins, 67% did not use the drug due to its high cost, 31% due to the lack of instruction, and only 2% due to side effects. Total cholesterol (260.3±42.2 vs 226.4±51.9; p<0.0001) and LDL cholesterol (174.6±38.1 vs 149.6±36.1; p<0.0001) were lower in patients on medication. HDL-cholesterol increased from 37.6±9.6 to 41.5±12.9mg/dL (p=0.02), and triglycerides were not modified in patients using statins. CONCLUSION: The prescription of statins in patients with coronary artery disease and dyslipidemia is high; however, its adherence is far from satisfactory, due to the high cost of the medication. Reduction in total cholesterol and LDL cholesterol levels did not reach the targets recommended by the Brazilian Consensus on Dyslipidemia.

  • adherence
  • Coronary Artery Disease
  • hypercholesterolemia
  • statins
Ler artigo completo
Creative Commons Attribution (CC BY) Creative Commons license
08/01/2002 DOI: 10.1590/S0066-782X2001000200002 Visualizações 1

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Nascimento E, Mello ALFP, Cunha LS, Villela MF. Acute Coronary Disease in very Young Patient: A Reality!. International Journal of Cardiovascular Sciences 2020;34(5 Supl 1):150-3.

Formato de Documento Eletrônico (ABNT)

Nascimento, Erivelton; Mello, Ana Luisa Freitas e Pena; Cunha, Ludmila Souza da; Villela, Marcelo Ferreira. Acute Coronary Disease in very Young Patient: A Reality!. International Journal of Cardiovascular Sciences, v. 34, n. 5 Supl 1, p. 150-153, nov. 2020.

Formato de Documento Eletrônico (APA)

Nascimento, E., Mello, A. L. F. P., Cunha, L. S. , & Villela, M. F. (2020). Acute Coronary Disease in very Young Patient: A Reality!. International Journal of Cardiovascular Sciences, 34(5 Supl 1), 150-153.

Formato de Documento Eletrônico (ISO)

Nascimento, Erivelton and Mello, Ana Luisa Freitas e Pena and Cunha, Ludmila Souza da and Villela, Marcelo Ferreira. Acute Coronary Disease in very Young Patient: A Reality!. International Journal of Cardiovascular Sciences [online]. 2020, vol. 34, n. 5 Supl 1, [citado 2026-10-14], pp. 150-153. Disponível em: <https://journals.cardiol.br/article/acute-coronary-disease-in-very-young-patient-a-reality-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Portal VL, Moriguchi EH, Vieira JLC, Schio S, Mastalir ET, Buffé F, Bortolini EB, et al. Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation. Arquivos Brasileiros de Cardiologia 2003;80(2):156-61.

Formato de Documento Eletrônico (ABNT)

Portal, Vera Lúcia; Moriguchi, Emílio H.; Vieira, José Luiz da Costa; Schio, Sadi; Mastalir, Eduardo T.; Buffé, Fabiana; Bortolini, Eleni Borges; Brüch, Ricardo Santalucia; Rodrigues, Rubem. Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation. Arquivos Brasileiros de Cardiologia, v. 80, n. 2, p. 156-161, abr. 2003.

Formato de Documento Eletrônico (APA)

Portal, V. L., Moriguchi, E. H., Vieira, J. L. C., Schio, S., Mastalir, E. T., Buffé, F., Bortolini, E. B., Brüch, R. S., & Rodrigues, R. (2003). Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation. Arquivos Brasileiros de Cardiologia, 80(2), 156-161.

Formato de Documento Eletrônico (ISO)

Portal, Vera Lúcia and Moriguchi, Emílio H. and Vieira, José Luiz da Costa and Schio, Sadi and Mastalir, Eduardo T. and Buffé, Fabiana and Bortolini, Eleni Borges and Brüch, Ricardo Santalucia and Rodrigues, Rubem. Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation. Arquivos Brasileiros de Cardiologia [online]. 2003, vol. 80, n. 2, [citado 2026-10-14], pp. 156-161. Disponível em: <https://journals.cardiol.br/article/comparison-of-the-effect-of-two-hmg-coa-reductase-inhibitors-on-ldl-susceptibility-to-oxidation-2/>. ISSN 0066-782X

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Mansur AP, Mattar APL, Tsubo CE, Simão DT, Yoshi FR, Daci K. Prescription and adherence to statins of patients with coronary artery disease and hypercholesterolemia. Arquivos Brasileiros de Cardiologia 2002;76(2):115-8.

Formato de Documento Eletrônico (ABNT)

Mansur, Antonio P.; Mattar, André P. L.; Tsubo, Cristiane E.; Simão, Danielle T.; Yoshi, Fábio R.; Daci, Kuang. Prescription and adherence to statins of patients with coronary artery disease and hypercholesterolemia. Arquivos Brasileiros de Cardiologia, v. 76, n. 2, p. 115-118, jan. 2002.

Formato de Documento Eletrônico (APA)

Mansur, A. P., Mattar, A. P. L., Tsubo, C. E., Simão, D. T., Yoshi, F. R., & Daci, K. (2002). Prescription and adherence to statins of patients with coronary artery disease and hypercholesterolemia. Arquivos Brasileiros de Cardiologia, 76(2), 115-118.

Formato de Documento Eletrônico (ISO)

Mansur, Antonio P. and Mattar, André P. L. and Tsubo, Cristiane E. and Simão, Danielle T. and Yoshi, Fábio R. and Daci, Kuang. Prescription and adherence to statins of patients with coronary artery disease and hypercholesterolemia. Arquivos Brasileiros de Cardiologia [online]. 2002, vol. 76, n. 2, [citado 2026-10-14], pp. 115-118. Disponível em: <https://journals.cardiol.br/article/prescription-and-adherence-to-statins-of-patients-with-coronary-artery-disease-and-hypercholesterolemia-2/>. ISSN 0066-782X

  • Sobre a Família ABC
  • Regimento Interno
  • Conselho Editorial
  • Sociedade Brasileira de Cardiologia (SBC)

Edições

Diretrizes da SBC

  • Vídeos
  • Podcasts
  • Notícias