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  2. Ischemic Stroke
IJCS
Case Report

Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador

Patricia Delgado Cedeño et al. Estefania Carolina Arteaga Herrera Cesar Joao Tumbaco Mite Elsie Valdivieso Valenzuela … Boris Barreno Vera Karen Llimaico Del Pin

Abstract

Mitral stenosis (MS) is a valvular disease that predominantly affects women, with rheumatic fever being the most prevalent etiological cause. The hemodynamic consequences of rheumatic MS may include left atrial (LA) pressure overload and dilation, atrial fibrillation (AF), secondary pulmonary hypertension, heart failure, atrial thrombosis, and systemic thromboembolism. Echocardiography is the gold standard for diagnosing, quantifying severity, and evaluating the hemodynamic impact of MS.

We present the case of a 41-year-old female patient who arrived at the emergency department with a 6-hour history of dysarthria and right hemiparesis. Cardiovascular examination revealed sinus rhythm and a diastolic murmur with an opening snap at the mitral focus. Imaging studies revealed severe MS with LA dilation and a patent foramen ovale without hemodynamic impact. The patient underwent percutaneous balloon mitral valvuloplasty, which resulted in an increase in mitral valve area (MVA), a reduction in pulmonary pressure, and significant functional improvement.

Cerebral thromboembolism can be the first manifestation of severe MS, even in patients with sinus rhythm. Anticoagulation is crucial for those with severe atrial dilation to reduce the risk of embolic events. This case highlights the importance of early diagnosis and appropriate treatment based on clinical guidelines, as they improve patient quality of life and reduce the risk of future complications. It also serves as a reminder that stroke may be the sentinel event in silent but severe mitral valve pathology.

  • Ischemic Stroke
  • Mitral Valve Stenosis
  • Rheumatic Heart Disease
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Creative Commons Attribution (CC BY) Creative Commons license
01/09/2025 DOI: 10.36660/ijcs.20250013 Visualizações 8
IJCS
Original Article

Percutaneous Patent Foramen Ovale Occlusion in Patients Over 60 Years of Age with History of Stroke

Marcelo Sabedotti et al. Luciano da Silva Selistre Agda Mezzomo Fabio Eduardo Camazzola … Ramiro Caldas Degrazia Bibiana Guimarães Maggi Sara Voltolini

Abstract

Background:

The prevalence of patent foramen ovale (PFO) is 27%. PFO is related to paradoxical embolism, which can cause ischemic stroke. Ischemic stroke without an identifiable cause is common, accounting for up to 40% of cases, and PFO is frequently found in these patients. The prevalence of PFO is almost 3 times higher in elderly patients with ischemic stroke without identified etiology, suggesting that these patients may also benefit from PFO closure.

Objectives:

The primary objective was to assess the recurrence of ischemic stroke or transient ischemic attack during clinical follow-up. The secondary objective was to assess the occurrence of procedural complications, onset of atrial fibrillation, and reduced anticoagulant use.

Methods:

This retrospective cohort study included 36 patients over 60 years of age with prior ischemic stroke who underwent PFO closure. Survival analysis was performed using the Kaplan-Meier model. Independence tests between categorical variables were performed using the chi-square test and Fisher’s exact test, adopting a significance level of 0.05.

Results:

The patients’ mean age was 69.6 ± 6.5 years, and 55.5% were men. No complications occurred during the procedures. Echocardiography was performed 30 days after the intervention, showing no residual shunts. During the follow-up of 58.9 ± 42.7 months, there were no cases of ischemic stroke, transient ischemic attack, or atrial fibrillation related to the procedure. The use of anticoagulants decreased from 41.7% to 5.6% (p = 0.03).

Conclusions:

Percutaneous PFO occlusion for the prevention of cerebrovascular events in individuals over 60 years of age with prior ischemic stroke is effective and safe, with a low risk of complications, and it can reduce the risk of bleeding by reducing the use of anticoagulants.

  • Aged
  • Ischemic Stroke
  • Patent Foramen Ovale
  • Percutaneous Occlusion
  • Stroke
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Creative Commons Attribution (CC BY) Creative Commons license
11/04/2025 DOI: 10.36660/ijcs.20240160 Visualizações 5
IJCS
Case Report

Acute Ischemic Stroke as the Only Clinical Manifestation of Spontaneous Coronary Artery Dissection in an Athlete: A Case Report

Isabela Martins Rodrigues et al. Dennis Miguel Lemos da Silva Fabiane Mian de Souza Gustavo Nahuel Leyes Ontivero … Rodrigo Penha de Almeida João Lucas O’Connel

Introduction

Spontaneous coronary artery dissection (SCAD) is a rare but important cause of acute coronary syndrome. SCAD involves the spontaneous formation of an intramural hematoma in coronary arteries, frequently presenting as severe acute-onset chest pain. Although extremely rare, cases of acute ischemic stroke (AIS) secondary to SCAD have been reported in the literature,,none of which were secondary to intracoronary thrombus displacement.

In this report, we present the case of a 39-year-old man with no atherosclerotic risk factors who presented with AIS and myocardial infarction secondary to SCAD.

[…]

  • acute coronary syndrome
  • Blood Vessel Dissection
  • Ischemic Stroke
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Creative Commons Attribution (CC BY) Creative Commons license
19/08/2024 DOI: 10.36660/ijcs.20230135 Visualizações 3

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Cedeño PD, Herrera ECA, Mite CJT, Valenzuela EV, Vera BB, Pin KLD. Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences 2025;38:e20250013.

Formato de Documento Eletrônico (ABNT)

Cedeño, Patricia Delgado; Herrera, Estefania Carolina Arteaga; Mite, Cesar Joao Tumbaco; Valenzuela, Elsie Valdivieso; Vera, Boris Barreno; Pin, Karen Llimaico Del. Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences, v. 38, e20250013, ago. 2025.

Formato de Documento Eletrônico (APA)

Cedeño, P. D., Herrera, E. C. A., Mite, C. J. T., Valenzuela, E. V., Vera, B. B., & Pin, K. L. D. (2025). Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences, 38, e20250013.

Formato de Documento Eletrônico (ISO)

Cedeño, Patricia Delgado and Herrera, Estefania Carolina Arteaga and Mite, Cesar Joao Tumbaco and Valenzuela, Elsie Valdivieso and Vera, Boris Barreno and Pin, Karen Llimaico Del. Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-11-15], e20250013. Disponível em: <https://journals.cardiol.br/article/cerebral-thromboembolism-as-a-primary-manifestation-of-severe-rheumatic-mitral-stenosis-a-clinical-case-from-guayaquil-ecuador-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Sabedotti M, Selistre LS, Mezzomo A, Camazzola FE, Degrazia RC, Maggi BG, Voltolini S, et al. Percutaneous Patent Foramen Ovale Occlusion in Patients Over 60 Years of Age with History of Stroke. International Journal of Cardiovascular Sciences 2025;38:e20240160.

Formato de Documento Eletrônico (ABNT)

Sabedotti, Marcelo; Selistre, Luciano da Silva; Mezzomo, Agda; Camazzola, Fabio Eduardo; Degrazia, Ramiro Caldas; Maggi, Bibiana Guimarães; Voltolini, Sara. Percutaneous Patent Foramen Ovale Occlusion in Patients Over 60 Years of Age with History of Stroke. International Journal of Cardiovascular Sciences, v. 38, e20240160, abr. 2025.

Formato de Documento Eletrônico (APA)

Sabedotti, M., Selistre, L. S., Mezzomo, A., Camazzola, F. E., Degrazia, R. C., Maggi, B. G., & Voltolini, S. (2025). Percutaneous Patent Foramen Ovale Occlusion in Patients Over 60 Years of Age with History of Stroke. International Journal of Cardiovascular Sciences, 38, e20240160.

Formato de Documento Eletrônico (ISO)

Sabedotti, Marcelo and Selistre, Luciano da Silva and Mezzomo, Agda and Camazzola, Fabio Eduardo and Degrazia, Ramiro Caldas and Maggi, Bibiana Guimarães and Voltolini, Sara. Percutaneous Patent Foramen Ovale Occlusion in Patients Over 60 Years of Age with History of Stroke. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-11-15], e20240160. Disponível em: <https://journals.cardiol.br/article/percutaneous-patent-foramen-ovale-occlusion-in-patients-over-60-years-of-age-with-history-of-stroke-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Rodrigues IM, Silva DML, Souza FM, Ontivero GNL, Almeida RP, O’Connel JL. Acute Ischemic Stroke as the Only Clinical Manifestation of Spontaneous Coronary Artery Dissection in an Athlete: A Case Report. International Journal of Cardiovascular Sciences 2024;37:e20230135.

Formato de Documento Eletrônico (ABNT)

Rodrigues, Isabela Martins; Silva, Dennis Miguel Lemos da; Souza, Fabiane Mian de; Ontivero, Gustavo Nahuel Leyes; Almeida, Rodrigo Penha de; O’Connel, João Lucas. Acute Ischemic Stroke as the Only Clinical Manifestation of Spontaneous Coronary Artery Dissection in an Athlete: A Case Report. International Journal of Cardiovascular Sciences, v. 37, e20230135, ago. 2024.

Formato de Documento Eletrônico (APA)

Rodrigues, I. M., Silva, D. M. L. , Souza, F. M. , Ontivero, G. N. L., Almeida, R. P. , & O’Connel, J. L. (2024). Acute Ischemic Stroke as the Only Clinical Manifestation of Spontaneous Coronary Artery Dissection in an Athlete: A Case Report. International Journal of Cardiovascular Sciences, 37, e20230135.

Formato de Documento Eletrônico (ISO)

Rodrigues, Isabela Martins and Silva, Dennis Miguel Lemos da and Souza, Fabiane Mian de and Ontivero, Gustavo Nahuel Leyes and Almeida, Rodrigo Penha de and O’Connel, João Lucas. Acute Ischemic Stroke as the Only Clinical Manifestation of Spontaneous Coronary Artery Dissection in an Athlete: A Case Report. International Journal of Cardiovascular Sciences [online]. 2024, vol. 37, [citado 2026-11-15], e20230135. Disponível em: <https://journals.cardiol.br/article/acute-ischemic-stroke-as-the-only-clinical-manifestation-of-spontaneous-coronary-artery-dissection-in-an-athlete-a-case-report-2/>. ISSN 2359-4802

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