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  2. Palavra-chave: Rheumatic Heart Disease
IJCS
Case Report

Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador

Patricia Delgado Cedeño et al. Estefania Carolina Arteaga Herrera Cesar Joao Tumbaco Mite Elsie Valdivieso Valenzuela … Boris Barreno Vera Karen Llimaico Del Pin

Abstract

Mitral stenosis (MS) is a valvular disease that predominantly affects women, with rheumatic fever being the most prevalent etiological cause. The hemodynamic consequences of rheumatic MS may include left atrial (LA) pressure overload and dilation, atrial fibrillation (AF), secondary pulmonary hypertension, heart failure, atrial thrombosis, and systemic thromboembolism. Echocardiography is the gold standard for diagnosing, quantifying severity, and evaluating the hemodynamic impact of MS.

We present the case of a 41-year-old female patient who arrived at the emergency department with a 6-hour history of dysarthria and right hemiparesis. Cardiovascular examination revealed sinus rhythm and a diastolic murmur with an opening snap at the mitral focus. Imaging studies revealed severe MS with LA dilation and a patent foramen ovale without hemodynamic impact. The patient underwent percutaneous balloon mitral valvuloplasty, which resulted in an increase in mitral valve area (MVA), a reduction in pulmonary pressure, and significant functional improvement.

Cerebral thromboembolism can be the first manifestation of severe MS, even in patients with sinus rhythm. Anticoagulation is crucial for those with severe atrial dilation to reduce the risk of embolic events. This case highlights the importance of early diagnosis and appropriate treatment based on clinical guidelines, as they improve patient quality of life and reduce the risk of future complications. It also serves as a reminder that stroke may be the sentinel event in silent but severe mitral valve pathology.

  • Ischemic Stroke
  • Mitral Valve Stenosis
  • Rheumatic Heart Disease
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Creative Commons Attribution (CC BY) Creative Commons license
01/09/2025 DOI: 10.36660/ijcs.20250013 Visualizações 1
IJCS
Original Article

The Association Between IL-4 Expression and Thrombus Events in Rheumatic Heart Disease Patients

Arini Rizky Wijayanti et al. Dyah Samti Mayasari Erika Maharani Hasanah Mumpuni … Sofia Pranacipta Emilia Theresia Nungki Anggorowati Ery Kus Dwianingsih

Abstract

Background:

Rheumatic heart disease (RHD) is the leading cause of valve disease in developing countries, with intracardiac thrombus events as one of the frequent manifestations. Based on Trias Virchow, a thrombus occurs because of endothelial injury, blood flow abnormality, and hypercoagulability. In RHD, this condition is caused by inflammation, mitral stenosis (MS), and atrial fibrillation (AF). Pro-inflammatory cytokines promote thrombus formation, and anti-inflammatory cytokines inhibit it. IL-4 is an anti-inflammatory cytokine that can potentially inhibit thrombus formation because it can inhibit other pro-inflammatory cytokines and polarize M2 macrophages.

Objectives:

This study aims to know the association of IL-4 expression with thrombus events in RHD patients.

Methods:

Twenty-five (25) patients enrolled in this study were diagnosed with RHD and underwent mitral valve replacement surgery. Valve tissues were collected for histopathological and immunohistochemical examination using IL-4. Thrombus event obtained from echocardiography result. The Mann-Whitney test was used to compare IL-4 expression in thrombus and non-thrombus patients. A p-value of less than 0.05 (p<0.05) was considered the significance level.

Results:

Of the 25 patients, 88% were older than 30 years. Thrombus occurs in 28% of RHD patients and is associated with AF (p 0.001). Patients with moderate and high IL-4 expression did not have less thrombus than patients with low IL-4 expression.

Conclusions:

Intracardiac thrombus formation in RHD patients is not associated with IL-4 expression but is strongly associated with AF. Further research that identifies other cytokines coexisting with IL-4 at the site of injury may reveal better insight into the event.

  • Atrial Fibrillation
  • Interleukin-4
  • Rheumatic Heart Disease
  • Thrombosis
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Creative Commons Attribution (CC BY) Creative Commons license
02/12/2024 DOI: 10.36660/ijcs.20240109 Visualizações 2
IJCS
Case Report

Cardiac Magnetic Resonance and Positron Emission Tomography in the Diagnosis and Follow-Up of Acute Rheumatic Fever – Case Report

David Salazar et al. Cristhian Espinoza Romero Mariana Pezzute Lopes Carlos Eduardo de Barros Branco … José Soares Junior Antonio de Santis Roney Orismar Sampaio Flávio Tarasoutchi

Introduction

Rheumatic fever (RF) is a prevalent condition in developing countries, accounting for a cardiac mortality of rate 7.9% in Brazil (DATASUS). Cases of rheumatic fever are often underdiagnosed and recognized only after permanent valve damage due to previous carditis. Secondary prevention of RF aims to limit the development and/or progression of valvular lesions and their complications. However, even on therapy with benzathine penicillin every 21 days, patients may experience recurrence of acute RF, making diagnosis a greater challenge. The development of new diagnostic methods can contribute to the early detection of rheumatic carditis (RC) considering that 90% of cases are subclinical. In addition, not only the usual gallium-67 scintigraphy, but also, tests such as cardiac nuclear magnetic resonance imaging (MRI) and positron emission tomography (PET-CT) may have the potential to be diagnostic tools in acute rheumatic carditis. However, more studies are needed to validate these methods. ,

[…]

  • Diagnostic Imaging
  • Epidemiology
  • Magnetic Resonance Spectroscopy/methods
  • Positron Emission Tomogaphy Computed Tomography/methods
  • Rheumatic Fever/physiopathology
  • Rheumatic Heart Disease
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Creative Commons Attribution (CC BY) Creative Commons license
22/04/2022 DOI: 10.36660/ijcs.20210093 Visualizações 1
IJCS
Original Article

Mortality Trends from Cardiovascular Diseases in the State of Bahia, Brazil, between 2000 and 2015

Yana Mendonça Nascimento et al. Adriana Lopes Latado

Abstract

Background:

Mortality from cardiovascular diseases has reduced in Brazil in recent decades, but this phenomenon is not clear in the northeast region of the country.

Objectives:

To describe the mortality trends from cardiovascular disease in Bahia from 2000-2015, in total population and by sex and age groups, and by specific causes (ischemic heart disease, cerebrovascular diseases, rheumatic heart disease and heart failure).

Methods:

This was a time series study. Data were obtained from SIM-DATASUS and IBGE, and the 10th revision of the ICD used for disease classification. Mortality rates (per 100,000 inhabitants) were calculated from total cardiovascular disease and specific causes, by sex and age groups. Direct standardization was used to adjust for age, using the population of 2010 as reference. Linear regression models estimated percentage variation. The significance level of 5% was adopted.

Results:

In Bahia, crude mortality rates from cardiovascular disease increased in the period; however, after standardization by age, mortality rates became stable for the total and female populations, with a slight reduction for the male population. An increase in mortality rates from cardiovascular disease was found in the elderly groups. For ischemic heart disease, a progressive increase in adjusted mortality rates was observed: 43%, 24% and 29% for the total, male, and female population, respectively. There was a progressive reduction in crude and age-standardized mortality rates from heart failure in all groups, a modest reduction in age-adjusted mortality rates from cerebrovascular diseases, and a slight reduction in age-standardized mortality rate from rheumatic heart disease, especially in the subgroup <40 years.

Conclusions:

Mortality from cardiovascular disease in Bahia did not follow the decreasing trend of other Brazilian states, especially in relation to ischemic heart disease, which showed an increase in mortality rates.

  • Cardiovascular Diseases, mortality
  • Cerebrovascular Disorders
  • Heart Failure
  • Myocardial Ischemia
  • Rheumatic
  • rheumatic fever
  • Rheumatic Heart Disease
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Creative Commons Attribution (CC BY) Creative Commons license
25/11/2020 DOI: 10.36660/ijcs.20200028 Visualizações 1
IJCS
Editorial

Rheumatic Heart Disease – How are We in 2019, Have We Evolved?

Andressa Mussi Soares

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with the sole member of the group A Streptococcus (GAS), Streptococcus pyogenes. ARF leads to a condition characterized by various combinations of joint pain and swelling, cardiac-valve regurgitation with the potential for secondary heart failure, chorea, skin and subcutaneous manifestations, and fever.

Rheumatic heart disease (RHD) is a disease of poverty that affects children and working-age adults. The global economic impact of early death from RHD is still very high. In Brazil, the average cost of RHD-related damage is around 89 million Brazilian reals (close to US$ 28 million) a year. Information from the Brazilian Unified National Health System database (DATASUS) indicates a cardiac mortality rate of about 7.9% from chronic rheumatic fever (RF).

[…]

  • chronic valvular heart disease
  • control programs
  • corticosteroids
  • Echocardiography
  • Rheumatic Heart Disease
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Creative Commons Attribution (CC BY) Creative Commons license
19/08/2019 DOI: 10.5935/2359-4802.20190041 Visualizações 1

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Cedeño PD, Herrera ECA, Mite CJT, Valenzuela EV, Vera BB, Pin KLD. Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences 2025;38:e20250013.

Formato de Documento Eletrônico (ABNT)

Cedeño, Patricia Delgado; Herrera, Estefania Carolina Arteaga; Mite, Cesar Joao Tumbaco; Valenzuela, Elsie Valdivieso; Vera, Boris Barreno; Pin, Karen Llimaico Del. Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences, v. 38, e20250013, ago. 2025.

Formato de Documento Eletrônico (APA)

Cedeño, P. D., Herrera, E. C. A., Mite, C. J. T., Valenzuela, E. V., Vera, B. B., & Pin, K. L. D. (2025). Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences, 38, e20250013.

Formato de Documento Eletrônico (ISO)

Cedeño, Patricia Delgado and Herrera, Estefania Carolina Arteaga and Mite, Cesar Joao Tumbaco and Valenzuela, Elsie Valdivieso and Vera, Boris Barreno and Pin, Karen Llimaico Del. Cerebral Thromboembolism as a Primary Manifestation of Severe Rheumatic Mitral Stenosis: A Clinical Case from Guayaquil, Ecuador. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-10-14], e20250013. Disponível em: <https://journals.cardiol.br/article/cerebral-thromboembolism-as-a-primary-manifestation-of-severe-rheumatic-mitral-stenosis-a-clinical-case-from-guayaquil-ecuador-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Wijayanti AR, Mayasari DS, Maharani E, Mumpuni H, Pranacipta S, Theresia E, Anggorowati N, et al. The Association Between IL-4 Expression and Thrombus Events in Rheumatic Heart Disease Patients. International Journal of Cardiovascular Sciences 2024;37:e20240109.

Formato de Documento Eletrônico (ABNT)

Wijayanti, Arini Rizky; Mayasari, Dyah Samti; Maharani, Erika; Mumpuni, Hasanah; Pranacipta, Sofia; Theresia, Emilia; Anggorowati, Nungki; Dwianingsih, Ery Kus. The Association Between IL-4 Expression and Thrombus Events in Rheumatic Heart Disease Patients. International Journal of Cardiovascular Sciences, v. 37, e20240109, dez. 2024.

Formato de Documento Eletrônico (APA)

Wijayanti, A. R., Mayasari, D. S., Maharani, E., Mumpuni, H., Pranacipta, S., Theresia, E., Anggorowati, N., & Dwianingsih, E. K. (2024). The Association Between IL-4 Expression and Thrombus Events in Rheumatic Heart Disease Patients. International Journal of Cardiovascular Sciences, 37, e20240109.

Formato de Documento Eletrônico (ISO)

Wijayanti, Arini Rizky and Mayasari, Dyah Samti and Maharani, Erika and Mumpuni, Hasanah and Pranacipta, Sofia and Theresia, Emilia and Anggorowati, Nungki and Dwianingsih, Ery Kus. The Association Between IL-4 Expression and Thrombus Events in Rheumatic Heart Disease Patients. International Journal of Cardiovascular Sciences [online]. 2024, vol. 37, [citado 2026-10-14], e20240109. Disponível em: <https://journals.cardiol.br/article/the-association-between-il-4-expression-and-thrombus-events-in-rheumatic-heart-disease-patients-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Salazar D, Romero CE, Lopes MP, Branco CEB, Soares Junior J, Santis A, Sampaio RO, et al. Cardiac Magnetic Resonance and Positron Emission Tomography in the Diagnosis and Follow-Up of Acute Rheumatic Fever – Case Report. International Journal of Cardiovascular Sciences 2022;36:e20210093.

Formato de Documento Eletrônico (ABNT)

Salazar, David; Romero, Cristhian Espinoza; Lopes, Mariana Pezzute; Branco, Carlos Eduardo de Barros; Soares Junior, José; Santis, Antonio de; Sampaio, Roney Orismar; Tarasoutchi, Flávio. Cardiac Magnetic Resonance and Positron Emission Tomography in the Diagnosis and Follow-Up of Acute Rheumatic Fever – Case Report. International Journal of Cardiovascular Sciences, v. 36, e20210093, abr. 2022.

Formato de Documento Eletrônico (APA)

Salazar, D., Romero, C. E., Lopes, M. P., Branco, C. E. B., Soares Junior, J., Santis, A. , Sampaio, R. O., & Tarasoutchi, F. (2022). Cardiac Magnetic Resonance and Positron Emission Tomography in the Diagnosis and Follow-Up of Acute Rheumatic Fever – Case Report. International Journal of Cardiovascular Sciences, 36, e20210093.

Formato de Documento Eletrônico (ISO)

Salazar, David and Romero, Cristhian Espinoza and Lopes, Mariana Pezzute and Branco, Carlos Eduardo de Barros and Soares Junior, José and Santis, Antonio de and Sampaio, Roney Orismar and Tarasoutchi, Flávio. Cardiac Magnetic Resonance and Positron Emission Tomography in the Diagnosis and Follow-Up of Acute Rheumatic Fever – Case Report. International Journal of Cardiovascular Sciences [online]. 2022, vol. 36, [citado 2026-10-14], e20210093. Disponível em: <https://journals.cardiol.br/article/cardiac-magnetic-resonance-and-positron-emission-tomography-in-the-diagnosis-and-follow-up-of-acute-rheumatic-fever-case-report-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Nascimento YM, Latado AL. Mortality Trends from Cardiovascular Diseases in the State of Bahia, Brazil, between 2000 and 2015. International Journal of Cardiovascular Sciences 2020;33(6):656-65.

Formato de Documento Eletrônico (ABNT)

Nascimento, Yana Mendonça; Latado, Adriana Lopes. Mortality Trends from Cardiovascular Diseases in the State of Bahia, Brazil, between 2000 and 2015. International Journal of Cardiovascular Sciences, v. 33, n. 6, p. 656-665, nov. 2020.

Formato de Documento Eletrônico (APA)

Nascimento, Y. M., & Latado, A. L. (2020). Mortality Trends from Cardiovascular Diseases in the State of Bahia, Brazil, between 2000 and 2015. International Journal of Cardiovascular Sciences, 33(6), 656-665.

Formato de Documento Eletrônico (ISO)

Nascimento, Yana Mendonça and Latado, Adriana Lopes. Mortality Trends from Cardiovascular Diseases in the State of Bahia, Brazil, between 2000 and 2015. International Journal of Cardiovascular Sciences [online]. 2020, vol. 33, n. 6, [citado 2026-10-14], pp. 656-665. Disponível em: <https://journals.cardiol.br/article/mortality-trends-from-cardiovascular-diseases-in-the-state-of-bahia-brazil-between-2000-and-2015-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Soares AM. Rheumatic Heart Disease – How are We in 2019, Have We Evolved?. International Journal of Cardiovascular Sciences 2019;32(5):435-7.

Formato de Documento Eletrônico (ABNT)

Soares, Andressa Mussi. Rheumatic Heart Disease – How are We in 2019, Have We Evolved?. International Journal of Cardiovascular Sciences, v. 32, n. 5, p. 435-437, ago. 2019.

Formato de Documento Eletrônico (APA)

Soares, A. M. (2019). Rheumatic Heart Disease – How are We in 2019, Have We Evolved?. International Journal of Cardiovascular Sciences, 32(5), 435-437.

Formato de Documento Eletrônico (ISO)

Soares, Andressa Mussi. Rheumatic Heart Disease – How are We in 2019, Have We Evolved?. International Journal of Cardiovascular Sciences [online]. 2019, vol. 32, n. 5, [citado 2026-10-14], pp. 435-437. Disponível em: <https://journals.cardiol.br/article/rheumatic-heart-disease-how-are-we-in-2019-have-we-evolved-2/>. ISSN 2359-4802

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