Indications of PCSK9 Inhibitors for Patients at High and Very High Cardiovascular Risk
LDL-C as a risk factor
The causality of plasma LDL-C levels and reduced LDL-C uptake mediated by the LDL-C receptor in the pathophysiology of CVD has been very consistently established. For patients at very high risk for premature events, such as those with familial hypercholesterolemia (FH), an elevated LDL-C level is an extremely prevalent risk factor.
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