Systemic, Inflammation

ABC

Editorial

Recurrent Pericarditis: A Manifestation of Systemic Inflammation?

Recurrent pericarditis represents one of the most challenging manifestations of pericardial diseases, due to its impact on quality of life, the prolonged use of anti-inflammatory therapies, and the risk of progression to refractoriness.^, Although classically described as an episodic condition, evidence indicates that, in a significant proportion of cases, recurrence may reflect persistent underlying systemic inflammation, often of an autoinflammatory nature, not fully captured by conventional inflammatory markers.^, In this context, recurrent pericarditis has evolved from a local approach to a systemic entity; inflammasome and interleukin-1 activation support more severe and recurrent phenotypes.^–

The Systemic Immune-Inflammation Index (SII), calculated as SII = (platelets × neutrophils)/lymphocytes, integrates central components of systemic inflammation and the immune response, reflecting the balance between innate and adaptive immunity and platelet activation.^– It differs from composite diagnostic scores, such as the INFLA-score. The SII constitutes a continuous quantitative biomarker, intended for estimating the underlying systemic inflammatory burden and for temporal monitoring of immuno-inflammatory activity.^–

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ABC

Research Letter

Pericardial Affections in Patients with COVID-19: A Possible Cause of Hemodynamic Deterioration

Fábio Fernandes et al. Felix José Alvarez Ramires Fábio Danziato Fernandes Marcus Vinicius Simões … Evandro Tinoco Mesquita Charles Mady

Introduction

The clinical course of the SARS-CoV-2 infection is characterized by respiratory symptoms, fever, cough, sore throat, fatigue, and complications related to the acute respiratory distress syndrome. However, some patients with initially mild symptoms can present clinical deterioration approximately one week after onset of the symptoms.

The acute progression of COVID-19 can be divided into 3 different phases: early infection, pulmonary phase, and hyperinflammation, and significant overlaps between these phases can occur.

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Recurrent Pericarditis: A Manifestation of Systemic Inflammation?

Pericardial Affections in Patients with COVID-19: A Possible Cause of Hemodynamic Deterioration

Introduction

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