Propafenone – ABC CARDIOL

IJCS

Case Report

Brugada Pattern, Brugada Phenocopy, What to Think?

José Luis Martins et al. Raquel Ferreira Jesus Viana José Santos

Introduction

Propafenone is a class 1 anti-arrhythmic medication with beta-adrenergic and calcium channel blocker properties.

Brugada syndrome (BrS) has a typical electrocardiographic pattern characterized by increased propensity for malignant ventricular arrhythmias and sudden death in patients with no structural heart disease.

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ABC

Case Report

Propafenone Overdose: From Cardiogenic Shock to Brugada Pattern

Julio Gil et al. Bruno Marmelo Luís Abreu Hugo Antunes … Luís Ferreira dos Santos José Costa Cabral

Introduction

Propafenone is a class IC antiarrhythmic drug used in the treatment of ventricular and supraventricular arrhythmias.^– It is primarily a potent sodium channel blocker, yet also exhibits beta-blocking and calcium channel blocking activity.^,^, Propafenone is able to induce important ECG changes, namely prolongation of the PR interval, bundle branch block, wide QRS and QT intervals, as well as ventricular tachycardia or bradycardia.^, It may be associated with significant proarrhythmogenic effects, even at therapeutic doses. A fatal overdose on propafenone is usually attributed to conduction abnormalities, leading to asystole or electromechanical dissociation. The authors describe two clinical cases of propafenone intoxication with life-threatening ECG changes, but with a favorable final outcome.

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Artigo Original

Effects of propafenone associated with propofol on myocardial contractility, heart rate, coronary flow, and the incidence of arrhythmia in isolated hearts of rats

Nilcéa Leal de Moraes Assis et al. Otoni Moreira Gomes Silvério Leonardo Macedo Garcia Guilherme Gustavo do Valle

OBJECTIVE: To study the influence of propafenone associated with propofol on myocardial contractility (dP/dt and heart rate), coronary flow, and the incidence of arrhythmia in isolated rat hearts. METHODS: Forty albino rats were anesthetized with sulfuric ether, a modified Langendorff method was performed, and the rats were fed with Krebs-Henseleit (K-H) solution, (95% O2, 5% CO2, pH 7.4±0.1, perfusion pressure between 90 and 100cm of water, and temperature 37± 0.5ºC). Control records were obtained after a stabilization period and rats were distributed into the following 4 groups: I (control), II (100mcg propafenone), III (25mcg propofol), and IV (propafenone-propofol). RESULTS: A decrease (P<0.05) in the heart rate in groups II and IV was observed, with a greater decrease in group II. A decrease was noted in the dP/dt ratio (P< 0.05) in groups II and IV, during all periods. Group III experienced depression from the 1st to the 3rd minute. Coronary flow had a decrease (P<0.05) in all groups, compared with the control group, especially in group IV with a decrease from 14mL/min to 11mL/min. Arrhythmogenic effects of propafenone (pro-arrhythmia) were verified in 50% of group II. In the association with propofol (group IV), no significant difference occurred, and arrhythmias (pro-arrhythmic effect) were observed in 40% of the hearts. CONCLUSION: The association propafenone-propofol was not harmful to the use of propafenone solely, regarding the effects observed in myocardial contractility, coronary flow, and in the incidence of arrhythmias.

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Original Article

Effect of Propafenone on the Contractile Activity of Latissimus Dorsi Muscle Isolated in an Organ Chamber: Experimental Study in Rats

Ricardo Simões et al. Eduardo Luis Guimarães Machado Odilon Gariglio de Alvarenga Freitas Maria da Consolação Vieira Moreira Otoni Moreira Gomes

OBJECTIVE: To study the effect of propafenone on the contractile function of latissimus dorsi muscle isolated from rats in an organ chamber. METHODS: We studied 20 latissimus dorsi muscles of Wistar rats and divided them into 2 groups: group I (n=10), or control group – we studied the feasibility of muscle contractility; group II (n=10), in which the contralateral muscles were grouped – we analyzed the effect of propafenone on muscle contractility. After building a muscle ring, 8 periods of sequential 2-minute baths were performed, with intervals of preprogrammed electrical stimulation using a pacemaker of 50 stimuli/min. In group II, propafenone, at the concentration of 9.8 µg/mL, was added to the bath in period 2 and withdrawn in period 4. RESULTS: In group I, no significant depression in muscle contraction occurred up to period 5 (p>0.05). In group II, a significant depression occurred in all periods, except between the last 2 periods (p0.05). CONCLUSION: Propafenone had a depressing effect on the contractile function of latissimus dorsi muscle isolated from rats and studied in an organ chamber.

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Brugada Pattern, Brugada Phenocopy, What to Think?

Introduction

Propafenone Overdose: From Cardiogenic Shock to Brugada Pattern

Introduction

Effects of propafenone associated with propofol on myocardial contractility, heart rate, coronary flow, and the incidence of arrhythmia in isolated hearts of rats

Effect of Propafenone on the Contractile Activity of Latissimus Dorsi Muscle Isolated in an Organ Chamber: Experimental Study in Rats

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Electronic Document Format (ABNT)

Electronic Document Format (APA)

Electronic Document Format (ISO)