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  2. Keyword: Postoperative Period
IJCS
Original Article

Impact of Coronary Artery Bypass Grafting on Muscle Mass Reduction on the 7th Postoperative Day

Bárbara de Oliveira Costa et al. Gabrielle Maciel Ana Beatriz Huguenin Geisiane da Silva … Sheila Moreira da Silva Guimarães Wanise Maria de Souza Cruz Alexandre Siciliano Colanfranceschi Gilson Teles Boaventura

Abstract

Background:

Ischemic heart failure is a chronic and degenerative disease with high morbidity and mortality in the world. Coronary artery bypass grafting is indicated as elective treatment and may cause a catabolic state that depletes energy reserves. Data on body composition evaluation in the postoperative period of major cardiac surgery are limited.

Objective:

To evaluate the influence of elective coronary artery bypass grafting on body composition on the seventh postoperative day of patients with ischemic heart failure.

Methods:

A cross-sectional study was carried out in which eighteen volunteers with New York Heart Association Class II and III heart failure underwent coronary artery bypass grafting. The energy and protein reserves of the participants were evaluated by anthropometry in the preoperative and on the seventh postoperative day. Paired t-Test or Mann-Whitney test was used if applicable. A significance level was considered at p value < 0.05.

Results:

A significant loss of muscle mass was observed through the reduction of arm muscle circumference after surgery (4.2%, p 0.007). Major surgery causes hypermetabolic state and systemic inflammatory stimulus, due to the release of hormones and cytokines that may justify the observed loss of muscle mass.

Conclusion:

Coronary artery bypass grafting had an impact on muscle mass reduction seven days after surgery in patients with ischemic heart failure.

  • Body Composition
  • Coronary,Artery Bypass Grafting
  • Heart Failure / mortality
  • Heart Failure/physiopathology
  • Postoperative Period
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Creative Commons Attribution (CC BY) Creative Commons license
01/04/2019 DOI: 10.5935/2359-4802.20190018
ABC
Original Article

Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization

Camila Stuchi Zarpelon et al. Miguel Chomiski Netto José Carlos Moura Jorge Cátia Carolina Fabris … Dieli Desengrini Mariana da Silva Jardim Diego Guedes da Silva

Abstract

Background:

The high prevalence of atrial fibrillation (AF) in the postoperative period of myocardial revascularization surgery increases morbidity and mortality.

Objective:

To assess the efficacy of colchicine to prevent AF in the postoperative period of myocardial revascularization surgery, the impact of AF on hospital length of stay and death, and to identify its risk factors.

Methods:

Between May 2012 and November 2013, 140 patients submitted to myocardial revascularization surgery were randomized, 69 to the control group and 71 to the colchicine group. Colchicine was used at the dose of 1 mg orally, twice daily, preoperatively, and of 0.5 mg, twice daily, until hospital discharge. A single dose of 1 mg was administered to those admitted 12 hours or less before surgery.

Results:

The primary endpoint was AF rate in the postoperative period of myocardial revascularization surgery. Colchicine group patients showed no reduction in AF incidence as compared to control group patients (7.04% versus 13.04%, respectively; p = 0.271). There was no statistically significant difference between the groups regarding death from any cause rate (5.6% versus 10.1%; p = 0,363) and hospital length of stay (14.5 ± 11.5 versus 13.3 ± 9.4 days; p = 0.490). However, colchicine group patients had a higher infection rate (26.8% versus 8.7%; p = 0.007).

Conclusion:

The use of colchicine to prevent AF after myocardial revascularization surgery was not effective in the present study. Brazilian Registry of Clinical Trials number RBR-556dhr.

  • Atrial Fibrillation / mortality
  • Colchicine/therapeutic use
  • Myocardial Revascularization
  • Postoperative Period
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Creative Commons Attribution (CC BY) Creative Commons license
24/05/2016 DOI: 10.5935/abc.20160082 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Costa BO, Maciel G, Huguenin AB, Silva G, Guimarães SMS, Cruz WMS, Colanfranceschi AS, et al. Impact of Coronary Artery Bypass Grafting on Muscle Mass Reduction on the 7th Postoperative Day. International Journal of Cardiovascular Sciences 2019;32(3):269-73.

Electronic Document Format (ABNT)

Costa, Bárbara de Oliveira; Maciel, Gabrielle; Huguenin, Ana Beatriz; Silva, Geisiane da; Guimarães, Sheila Moreira da Silva; Cruz, Wanise Maria de Souza; Colanfranceschi, Alexandre Siciliano; Boaventura, Gilson Teles. Impact of Coronary Artery Bypass Grafting on Muscle Mass Reduction on the 7th Postoperative Day. International Journal of Cardiovascular Sciences, v. 32, n. 3, p. 269-273, Mar. 2019.

Electronic Document Format (APA)

Costa, B. O., Maciel, G., Huguenin, A. B., Silva, G. , Guimarães, S. M. S., Cruz, W. M. S., Colanfranceschi, A. S., & Boaventura, G. T. (2019). Impact of Coronary Artery Bypass Grafting on Muscle Mass Reduction on the 7th Postoperative Day. International Journal of Cardiovascular Sciences, 32(3), 269-273.

Electronic Document Format (ISO)

Costa, Bárbara de Oliveira and Maciel, Gabrielle and Huguenin, Ana Beatriz and Silva, Geisiane da and Guimarães, Sheila Moreira da Silva and Cruz, Wanise Maria de Souza and Colanfranceschi, Alexandre Siciliano and Boaventura, Gilson Teles. Impact of Coronary Artery Bypass Grafting on Muscle Mass Reduction on the 7th Postoperative Day. International Journal of Cardiovascular Sciences [online]. 2019, vol. 32, n. 3, [cited 2026-10-14], pp. 269-273. Available from: <https://journals.cardiol.br/en/article/impact-of-coronary-artery-bypass-grafting-on-muscle-mass-reduction-on-the-7th-postoperative-day/>. ISSN 2359-4802

EndNote RIS

Electronic Document Format (Vancouver)

Zarpelon CS, Netto MC, Jorge JCM, Fabris CC, Desengrini D, Jardim MS, Silva DG, et al. Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization. Arquivos Brasileiros de Cardiologia 2016;107(1):4-9.

Electronic Document Format (ABNT)

Zarpelon, Camila Stuchi; Netto, Miguel Chomiski; Jorge, José Carlos Moura; Fabris, Cátia Carolina; Desengrini, Dieli; Jardim, Mariana da Silva; Silva, Diego Guedes da. Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization. Arquivos Brasileiros de Cardiologia, v. 107, n. 1, p. 4-9, May. 2016.

Electronic Document Format (APA)

Zarpelon, C. S., Netto, M. C., Jorge, J. C. M., Fabris, C. C., Desengrini, D., Jardim, M. S., & Silva, D. G. (2016). Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization. Arquivos Brasileiros de Cardiologia, 107(1), 4-9.

Electronic Document Format (ISO)

Zarpelon, Camila Stuchi and Netto, Miguel Chomiski and Jorge, José Carlos Moura and Fabris, Cátia Carolina and Desengrini, Dieli and Jardim, Mariana da Silva and Silva, Diego Guedes da. Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization. Arquivos Brasileiros de Cardiologia [online]. 2016, vol. 107, n. 1, [cited 2026-10-14], pp. 4-9. Available from: <https://journals.cardiol.br/en/article/colchicine-to-reduce-atrial-fibrillation-in-the-postoperative-period-of-myocardial-revascularization/>. ISSN 0066-782X

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