ABC Family Arquivos Brasileiros de Cardiologia International Journal of Cardiovascular Sciences ABC Heart Failure & Cardiomyopathy ABC Imagem Cardiovascular
Português English
ABC Family
Português English
  • About
    • About ABC Family
    • Internal Regulation
    • Editorial Board
    • Brazilian Society of Cardiology (SBC)
  • Issues
  • SBC Guidelines
  • Content
    • Videos
    • Podcasts
    • News
  • About
    • About ABC Family
    • Internal Regulation
    • Editorial Board
    • Brazilian Society of Cardiology (SBC)
  • Issues
  • SBC Guidelines
  • Content
    • Videos
    • Podcasts
    • News

ABC Family

  • ABC Family
  • Arquivos Brasileiros de Cardiologia
  • International Journal of Cardiovascular Sciences
  • ABC Heart Failure & Cardiomyopathy
  • ABC Imagem Cardiovascular
Search in

No content found.

Journals
Ordering
Article types
Others

  1. Home
  2. Keyword: dexamethasone
ABC
Editorial

The Astronaut and the Jabuticaba

Andre d’Avila et al. Marco F. Vidal Melo

Jabuticaba

Brazil has a peculiar medical environment. Although interventions like hydroxychloroquine and ivermectin disappeared from the international scientific debate once disproved in clinical trials, Brazilian practitioners continue to debate the validity of these studies. Like jabuticaba – a fruit native to and predominant (but not exclusive) in Brazil – this debate is still current only in this country. Previous attempts to discount the results of studies with the argument that they had been conducted abroad and could not be extended to the Brazilian population can no longer be justified as many of these studies have included Brazilian patients. As individuals, we do understand the difficulty in accepting evidence opposing someone’s conviction; however, as a doctor, this attitude is indefensible.

In this context of conviction and belief over evidence and data, several practitioners have created websites and even solicited the government to support and disseminate their practice despite proven inefficacy of the proposed interventions. Even though many are excellent physicians in their fields, this situation has only been possible because, under the auspices of trying to help, almost anything has been allowed in Brazil. If there were any regulation proposing a fine or termination of medical license to those who supported unproven medical practices, none of this would have happened. This regulation would be, in fact, similar to previous decisions of ethics committees in cases of charlatanism, when medical practices based on consensual decisions are not accepted as justification to exempt the infringer. However, these types of regulations are defective or absent in Brazil. Curiously, the term “accountability”, that in English means an obligation or willingness to accept responsibility for one’s actions, does not exist in Portuguese. On the other hand, there is no English word for “jabuticaba”.

[…]

  • Anti-Inflamatory
  • COVID-19
  • dexamethasone
  • Hydroxychloroquine
  • Pandemics/prevention and control
  • SARS-CoV-2
Read Full Article
Creative Commons Attribution (CC BY) Creative Commons license
03/02/2021 DOI: 10.36660/abc.20201098 Views 1
Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids
ABC
Artigo Original

Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids

Carlos Hermano da Justa Pinheiro et al. Wilson Martins de Sousa Filho Joselito de Oliveira Neto Maria de Jesus Ferreira Marinho … Renato Motta Neto Manuela Maria Ramos Lima Smith Carlos Antônio Bruno da Silva

BACKGROUND: Chronically, glucocorticoids induce adverse cardiometabolic alterations including insulin resistance, diabetes, dyslipidemia, liver steatosis and arterial hypertension. OBJECTIVES: To evaluate the effect of regular practice of aerobic exercise on cardiometabolic alterations induced by chronic administration of dexamethasone (Dex – 0.5 mg/kg/day ip) in rats. METHODS: Male Wistar rats (n = 24) were divided in four groups: Control group; Trained group; Treated with Dex group and Treated with Dex and trained group. The exercise training (initiated 72 hours after the first dose of Dex) was carried out three times a week until the end of the treatment. At the end of this period, the following biochemical assessments were performed: fasting glycemia, oral glucose tolerance test and analysis of the blood lipid profile that included total cholesterol (TC), LDL-c, HDL-c, VLDL-c and triglycerides (TG). The weight of the gastrocnemius muscle, the histopathological analysis of the liver and cardiometabolic indices (TC/HDL-c, LDL-c/HDL-c and TG/HDL-c) were also performed. RESULTS: Hyperglycemia, lower glucose tolerance, increased TC, LDL-c, VLDL-c, TG, CT/HDL-c, LDL-c/HDL-c and TG/HDL-c, decreased HDL-c, presence of liver steatosis and muscular hypotrophy were observed in the animals treated with Dex. The exercise training reduced hyperglycemia, improved glucose tolerance, decreased dyslipidemia and prevented liver steatosis, muscular hypotrophy and reduced CT/HDL-c, LDL-c/HDL-c and TG/HDL-c ratios. However, there was no significant effect on HDL-c. CONCLUSION: The aerobic exercise training have a protective effect against the cardiometabolic alterations induced by the chronic use of glucocorticoids.

  • Cholesterol
  • dexamethasone
  • dyslipidemia
  • Exercise
  • glucocorticoid
  • Insulin Resistance
Read Full Article
Creative Commons Attribution (CC BY) Creative Commons license
24/11/2009 DOI: 10.1590/S0066-782X2009001000014

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

d’Avila A, Melo MFV. The Astronaut and the Jabuticaba. Arquivos Brasileiros de Cardiologia 2021;116(1):1-3.

Electronic Document Format (ABNT)

d’Avila, Andre; Melo, Marco F. Vidal. The Astronaut and the Jabuticaba. Arquivos Brasileiros de Cardiologia, v. 116, n. 1, p. 1-3, Feb. 2021.

Electronic Document Format (APA)

d’Avila, A., & Melo, M. F. V. (2021). The Astronaut and the Jabuticaba. Arquivos Brasileiros de Cardiologia, 116(1), 1-3.

Electronic Document Format (ISO)

d’Avila, Andre and Melo, Marco F. Vidal. The Astronaut and the Jabuticaba. Arquivos Brasileiros de Cardiologia [online]. 2021, vol. 116, n. 1, [cited 2026-10-14], pp. 1-3. Available from: <https://journals.cardiol.br/en/article/the-astronaut-and-the-jabuticaba/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Pinheiro CHJ, Sousa Filho WM, Oliveira Neto J, Marinho MJF, Motta Neto R, Smith MMRL, Silva CAB, et al. Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids. Arquivos Brasileiros de Cardiologia 2009;93(4):400-8.

Electronic Document Format (ABNT)

Pinheiro, Carlos Hermano da Justa; Sousa Filho, Wilson Martins de; Oliveira Neto, Joselito de; Marinho, Maria de Jesus Ferreira; Motta Neto, Renato; Smith, Manuela Maria Ramos Lima; Silva, Carlos Antônio Bruno da. Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids. Arquivos Brasileiros de Cardiologia, v. 93, n. 4, p. 400-408, Nov. 2009.

Electronic Document Format (APA)

Pinheiro, C. H. J., Sousa Filho, W. M. , Oliveira Neto, J. , Marinho, M. J. F., Motta Neto, R., Smith, M. M. R. L., & Silva, C. A. B. (2009). Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids. Arquivos Brasileiros de Cardiologia, 93(4), 400-408.

Electronic Document Format (ISO)

Pinheiro, Carlos Hermano da Justa and Sousa Filho, Wilson Martins de and Oliveira Neto, Joselito de and Marinho, Maria de Jesus Ferreira and Motta Neto, Renato and Smith, Manuela Maria Ramos Lima and Silva, Carlos Antônio Bruno da. Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids. Arquivos Brasileiros de Cardiologia [online]. 2009, vol. 93, n. 4, [cited 2026-10-14], pp. 400-408. Available from: <https://journals.cardiol.br/en/article/exercise-prevents-cardiometabolic-alterations-induced-by-chronic-use-of-glucocorticoids/>. ISSN 0066-782X

  • About ABC Family
  • Internal Regulation
  • Editorial Board
  • Brazilian Society of Cardiology (SBC)

Issues

SBC Guidelines

  • Videos
  • Podcasts
  • News