Cardiomyopathy, Hypertrophic/genetics

ABC

Editorial

Echocardiography Guiding Percutaneous Treatment of Obstructive Hypertrophic Cardiomyopathy: Navigating (In Known Waters) Is Necessary

Obstructive hypertrophic cardiomyopathy (HOCM) is the most common cardiac genetic disease and, besides the risk of malignant arrhythmias, it is responsible for symptoms such as palpitations, syncope, or presyncope, exertional dyspnea, and angina pectoris. Ten percent of patients are refractory to clinical treatment with beta-blockers or calcium channel blockers. Treatment alternatives such as surgical myectomy (SM) or non-invasive methods to reduce left ventricle outflow obstruction may be considered in this population.^,

Although surgical myectomy is considered safe and the procedure of choice in experienced centers, it still has a percentage of post-procedure complications such as tamponade, interventricular septal communication, cerebrovascular accident dissection of coronary arteries, and non-fatal cardiac arrest. Controversy still exists about non-surgical hemodynamic treatment options, and the Heart Team’s expertise is an important factor regarding decisions.

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ABC

Review Article

Hypertrophic Cardiomyopathy: A Review

Silméia Garcia Zanati Bazan et al. Gilberto Ornellas de Oliveira Caroline Ferreira da Silva Mazeto Pupo da Silveira Fabrício Moreira Reis … Karina Nogueira Dias Secco Malagutte Lucas Santos Nielsen Tinasi Rodrigo Bazan João Carlos Hueb Katashi Okoshi

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common heart disease with a genetic origin, and its main characteristic is left ventricular hypertrophy that occurs in the absence of other conditions that trigger this change. HCM may present from asymptomatic forms to manifestations of sudden cardiac death and severe heart failure. Contemporary high-resolution imaging methods and more accurate clinical scores have been used and developed to provide a prognostic assessment and adequate functional assessments, as well as to allow for the stratification of clinical severity. These aspects will be addressed in this review, along with other classic topics inherent to the study of this disease.

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Echocardiography Guiding Percutaneous Treatment of Obstructive Hypertrophic Cardiomyopathy: Navigating (In Known Waters) Is Necessary

Hypertrophic Cardiomyopathy: A Review

Abstract

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