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  2. Palavra-chave: Obstructive Sleep Apnea
IJCS
Original Article

Obstructive Sleep Apnea as a Risk Factor for Ischemic Heart Disease

Soham Samajpaty et al. Alexander Konstantinovich Zhuravlov Emilianovich Dmitrii Ilin Yuriy Sergeivich

Abstract

Background:

Obstructive sleep apnea (OSA) is increasingly recognized as a potential risk factor for ischemic heart disease (IHD), but its role remains underexplored. This study investigated the association between OSA and IHD using a case-control design.

Objectives:

The objective of this study was to establish OSA as a risk factor for developing IHD.

Methods:

A total of 122 participants were recruited and categorized into two groups: patients with a recent history of IHD (< 7 days) (wIHD group, n = 61) and controls without IHD but with hypertension (cIHD group, n = 61). The STOP-Bang questionnaire was used to assess OSA risk, and statistical analyses, including odds ratio (OR), relative risk (RR), and attributable risk (AR), were performed. A significance level of 0.05 was adopted for all statistical analyses.

Results:

Patients in the wIHD group had significantly higher STOP-Bang scores than the control group (p 1). The level of statistical significance was found to be 0.05.

Conclusion:

This study identifies OSA as an important risk factor for IHD, supporting the need for routine OSA screening in cardiovascular risk assessment. Larger studies are needed to further explore this relationship

  • Case-Control Studies
  • Myocardial Ischemia
  • Obstructive Sleep Apnea
  • Risk Factors
Ler artigo completo
Creative Commons Attribution (CC BY) Creative Commons license
13/03/2026 DOI: 10.36660/ijcs.20240250 Visualizações 2
IJCS
Editorial

Obstructive Sleep Apnea in Acute Myocardial Infarction: A Prognostic Risk Factor beyond Traditional Players?

Carlos Wollmann et al. Luciano F. Drager

The high prevalence of obstructive sleep apnea (OSA) and its worrisome association with various cardiovascular diseases, particularly ischemic heart disease, demand our attention. This common sleep disordered breathing, characterized by partial or complete upper airway obstructions during sleep, profoundly impacts overall health., In the cardiovascular context, intermittent hypoxia, sleep fragmentation, and intrathoracic pressure swings promoted by repeated respiratory events during sleep promote several potentially deleterious phenomena, including increased sympathetic activity, blood pressure fluctuations, chronic systemic inflammation, reactive oxygen species production, and endothelial dysfunction.– These factors create a fertile ground for the development and progression of atherosclerosis,, significantly increasing the likelihood of ischemic events if the condition remains undetected and untreated., However, the relationship between OSA and acute myocardial infarction (AMI) is complex. Patients with OSA often share risk factors that also increase AMI risk, notably age, male sex, and obesity. While some evidence suggests an independent role for OSA in the cardiovascular risk, its contribution remains controversial in high-risk patients with multiple comorbidities. Further research in this area is therefore warranted in order to provide additional insights.

In this issue of the International Journal of Cardiovascular Sciences, Carrijo et al. explore the complex relationship between OSA and traditional risk factors in 145 patients with ST-segment elevation myocardial infarction (STEMI). The authors used employed the widely used STOP-BANG questionnaire to assess OSA risk. The initial results were consistent with previous literature: a high frequency (58.6%) of patients exhibited a high risk for OSA. This highlights the urgent need for increased attention to this comorbidity, particularly in this specific patient population. In the multivariate analysis, the authors found an independent association of OSA with both male sex and hypertension in these patients. The presence of hypertension in OSA patients is not coincidental. Some of the aforementioned mechanisms associated with OSA directly contribute to elevated blood pressure, thereby increasing cardiovascular risk.,

[…]

  • Myocardial Infarction
  • Obstructive Sleep Apnea
  • Prognosis
  • Risk Factors
  • Sleep
Ler artigo completo
Creative Commons Attribution (CC BY) Creative Commons license
08/05/2025 DOI: 10.36660/ijcs.20250032 Visualizações 3
IJCS
Original Article

Associated Factors to the Risk of Obstructive Sleep Apnea in the Acute Phase of Myocardial Infarction

Ludmylla da Silva Soares Carrijo et al. Patricia Magnabosco Maria Beatriz Guimarães Raponi Maria Angélica Melo e Oliveira … Suely Amorim de Araújo Luiz Claudio Martins Valéria Nasser Figueiredo

Abstract

Background

Obstructive sleep apnea (OSA) promotes endothelial dysfunction and systemic inflammation, and it is associated with shorter long-term survival and unfavorable clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI).

Objectives

To investigate the factors associated with the risk of OSA in the aftermath of STEMI.

Methods

A cross-sectional, quantitative study conducted with 145 individuals with STEMI in a large Brazilian teaching hospital. Anthropometric measurements were performed in addition to collecting sociodemographic/clinical data and lifestyle habits. The STOP-BANG questionnaire was used to determine the risk of OSA. The results were analyzed using descriptive statistics, association tests, and logistic regression. A significance level of 5% was adopted for the statistical analysis.

Results

The mean age of the participants was 62 ± 12 years, with a predominance of males (71%), white individuals (57.2%), and those at high risk of OSA (58.6%). Moderate to high risk of OSA was associated with male gender, hypertension, and dyslipidemia. Gender (HR = 6.13, 95% CI [1.88, 20.03], p = 0.003) and hypertension (HR = 4.31, 95% CI [1.27, 14.63], p = 0.019) were factors influencing the risk of OSA after acute myocardial infarction.

Conclusions

Hypertension and male gender were significant factors for a moderate/high risk of OSA in infarcted patients.

  • Myocardial Infarction
  • Obstructive Sleep Apnea
  • Risk Factors
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Creative Commons Attribution (CC BY) Creative Commons license
10/02/2025 DOI: 10.36660/ijcs.20240008 Visualizações 1

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Samajpaty S, Zhuravlov AK, Dmitrii E, Sergeivich IY. Obstructive Sleep Apnea as a Risk Factor for Ischemic Heart Disease. International Journal of Cardiovascular Sciences 2026;39:e20240250.

Formato de Documento Eletrônico (ABNT)

Samajpaty, Soham; Zhuravlov, Alexander Konstantinovich; Dmitrii, Emilianovich; Sergeivich, Ilin Yuriy. Obstructive Sleep Apnea as a Risk Factor for Ischemic Heart Disease. International Journal of Cardiovascular Sciences, v. 39, e20240250, mar. 2026.

Formato de Documento Eletrônico (APA)

Samajpaty, S., Zhuravlov, A. K., Dmitrii, E., & Sergeivich, I. Y. (2026). Obstructive Sleep Apnea as a Risk Factor for Ischemic Heart Disease. International Journal of Cardiovascular Sciences, 39, e20240250.

Formato de Documento Eletrônico (ISO)

Samajpaty, Soham and Zhuravlov, Alexander Konstantinovich and Dmitrii, Emilianovich and Sergeivich, Ilin Yuriy. Obstructive Sleep Apnea as a Risk Factor for Ischemic Heart Disease. International Journal of Cardiovascular Sciences [online]. 2026, vol. 39, [citado 2026-10-14], e20240250. Disponível em: <https://journals.cardiol.br/article/obstructive-sleep-apnea-as-a-risk-factor-for-ischemic-heart-disease-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Wollmann C, Drager LF. Obstructive Sleep Apnea in Acute Myocardial Infarction: A Prognostic Risk Factor beyond Traditional Players?. International Journal of Cardiovascular Sciences 2025;38:e20250032.

Formato de Documento Eletrônico (ABNT)

Wollmann, Carlos; Drager, Luciano F.. Obstructive Sleep Apnea in Acute Myocardial Infarction: A Prognostic Risk Factor beyond Traditional Players?. International Journal of Cardiovascular Sciences, v. 38, e20250032, maio. 2025.

Formato de Documento Eletrônico (APA)

Wollmann, C., & Drager, L. F. (2025). Obstructive Sleep Apnea in Acute Myocardial Infarction: A Prognostic Risk Factor beyond Traditional Players?. International Journal of Cardiovascular Sciences, 38, e20250032.

Formato de Documento Eletrônico (ISO)

Wollmann, Carlos and Drager, Luciano F.. Obstructive Sleep Apnea in Acute Myocardial Infarction: A Prognostic Risk Factor beyond Traditional Players?. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-10-14], e20250032. Disponível em: <https://journals.cardiol.br/article/obstructive-sleep-apnea-in-acute-myocardial-infarction-a-prognostic-risk-factor-beyond-traditional-players-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Carrijo LSS, Magnabosco P, Raponi MBG, Oliveira MAM, Araújo SA, Martins LC, Figueiredo VN, et al. Associated Factors to the Risk of Obstructive Sleep Apnea in the Acute Phase of Myocardial Infarction. International Journal of Cardiovascular Sciences 2025;38:e20240008.

Formato de Documento Eletrônico (ABNT)

Carrijo, Ludmylla da Silva Soares; Magnabosco, Patricia; Raponi, Maria Beatriz Guimarães; Oliveira, Maria Angélica Melo e; Araújo, Suely Amorim de; Martins, Luiz Claudio; Figueiredo, Valéria Nasser. Associated Factors to the Risk of Obstructive Sleep Apnea in the Acute Phase of Myocardial Infarction. International Journal of Cardiovascular Sciences, v. 38, e20240008, fev. 2025.

Formato de Documento Eletrônico (APA)

Carrijo, L. S. S., Magnabosco, P., Raponi, M. B. G., Oliveira, M. A. M. , Araújo, S. A. , Martins, L. C., & Figueiredo, V. N. (2025). Associated Factors to the Risk of Obstructive Sleep Apnea in the Acute Phase of Myocardial Infarction. International Journal of Cardiovascular Sciences, 38, e20240008.

Formato de Documento Eletrônico (ISO)

Carrijo, Ludmylla da Silva Soares and Magnabosco, Patricia and Raponi, Maria Beatriz Guimarães and Oliveira, Maria Angélica Melo e and Araújo, Suely Amorim de and Martins, Luiz Claudio and Figueiredo, Valéria Nasser. Associated Factors to the Risk of Obstructive Sleep Apnea in the Acute Phase of Myocardial Infarction. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-10-14], e20240008. Disponível em: <https://journals.cardiol.br/article/associated-factors-to-the-risk-of-obstructive-sleep-apnea-in-the-acute-phase-of-myocardial-infarction-2/>. ISSN 2359-4802

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