Heart Failure with Improved Ejection Fraction

Abstract

Cardiac remodeling is generally an adverse sign linked to the progression of heart failure (HF). However, in remodeled hearts, reverse remodeling is an important sign of cardiac recovery associated with a better prognosis. Ejection fraction may improve spontaneously following resolution of the processes that promote cardiac dilatation. In HF with reduced ejection fraction, treatment with neurohormonal blockade is an important strategy to promote improvements in ejection fraction. Improved ejection fraction can identify recovered patients with a better prognosis. In patients with HF with reduced or mildly reduced ejection fraction undergoing treatment, we should always investigate the ejection fraction development and optimize treatment by targeting an improved ejection fraction.

HF with improved ejection fraction is a current topic with several new publications, and given its importance, it has been highlighted in the main HF guidelines.