Heart Failure in Brazil: How Can We Improve its Natural History?

Heart failure (HF) is a complex syndrome with high morbidity and mortality rates worldwide.^, Despite significant efforts, including several recent clinical trials involving tens of thousands of patients and various pharmacologic therapies,^– reducing the burden of HF remains a challenge.

As of 2021, epidemiological data estimated that approximately 57 million people were affected by HF globally, and its prevalence is projected to rise by 34% in the coming decades. Patients hospitalized due to worsening HF are among the highest-risk groups, facing elevated rates of readmission and mortality, particularly during the vulnerable period shortly after discharge. The economic burden of HF is also significant; by 2030, HF-related costs in the U.S. are projected to exceed $70 billion annually.

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