José Mário M. Brandão et al. Andrea Miziara Geraldo Luiz de Figueiredo Moysés O. Lima-Filho … Elias M. Ayres-Neto José Antonio Marin-Neto
OBJECTIVE: To determine the existence and frequency of the phenomenon of post-extrasystolic potentiation in dysynergic myocardial areas of patients with chronic Chagas’ heart disease studied by use of radiologic contrast ventriculography. METHODS: This study is a semiquantitative retrospective analysis of radiologic contrast ventriculography in patients with chronic Chagas’ disease, who were consecutively studied to assess the mechanisms of ventricular tachycardia. RESULTS: Of the 72 patients initially included, in only 20 patients was possible the ventriculographic analysis for the purposes of this study. The phenomenon of post-extrasystolic potentiation was observed in 11 (55%) of these patients, and a 15.31% improvement was observed in the contractility score from the baseline to the post-extrasystole condition (P=0.0001). That phenomenon occurred even in ventricular segments with an intense deficit in contractility. CONCLUSION: The phenomenon of post-extrasystolic potentiation is observed in a significant proportion of patients with chronic Chagas’ heart disease, in whom the phenomenon could be angiographically analyzed, indicating the existence of potentially recruitable contractile reserve in ventricular regions, showing marked dysynergy. Additional studies for clarifying the underlying mechanisms are required.
