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  2. Keyword: captopril
ABC
Brief Communication

Analysis of the prescription of captopril to hospitalized patients

Márcio Galvão Oliveira et al. Antônio Carlos Beisl Noblat Lúcia Noblat Luiz Carlos Passos

One of the most common complications of Systemic Arterial Hypertension is the hypertensive crisis¹ characterized by a symptomatic elevation of blood pressure (BP) with or without involvement of target organs, which may lead to immediate or potential risk to life2-4. The hypertensive crisis may manifest itself as hypertensive emergency or urgency. In the emergency there is fast deterioration of target organs and immediate risk to life, a situation that does not occur in hypertensive urgency2-4. On the other hand, situations in which the patient presents elevated BP due to an emotionally charged, painful or uncomfortable event, with no evidence of lesion of target organs or immediate risk to life, characterize the hypertensive pseudo-crisis, a condition that does not require the use of emergency antihypertensive therapy1-3,5. Despite this fact, the practice has become widespread of prescribing antihypertensive medication prior to situations believed to present a risk of abrupt BP elevation, irrespective of the symptoms. This study aims at assessing the frequency of prescription of captopril prior to BP elevation in patients hospitalized in a university hospital. It was also intended to map the places (clinical or surgical wards) where this procedure was more frequent.

  • captopril
  • Hypertension
  • Inpatients
  • Prescriptions
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Creative Commons Attribution (CC BY) Creative Commons license
05/01/2009 DOI: 10.1590/S0066-782X2008001800009 Views 2
ABC
Artigo Original

Association of captopril and hydrochlorothiazide in mild and moderate hypertension

José Luiz Santello et al. Décio Mion Jr

PURPOSE: To evaluate the effectiveness and tolerance of the association of captopril 50mg and hydrochlorithiazide 25mg in hypertensive patients with diastolic pressure between 95 and 115 mmHg. METHODS: An open, multicenter and non-comparative study was performed. After 2 weeks of placebo, the patients received ½ tablet of drug association. Patients were evaluated after 4, 8 and 12 weeks, and those who had diastolic pressure >90mmHg after 8 weeks of therapy received 1 tablet/day. RESULTS: The results of 433 patients were analyzed: 47±10 years old, 30% female, 76% white. Initial systolic and diastolic pressures were 156±16 and 103±11mmHg and after 14 days of placebo were 156±15 and 103±9mmHg (p>0.05). Systolic/diastolic pressure after 4, 8 and 12 weeks of treatment reduced progressively (p<0.05) to 143±14/95±11, 140±13/91±9 and 134±11/86±8mmHg. Blood pressure control was observed in 45, 67 and 88% (p<0.05) of patients after 4, 8 and 12 weeks. Cough was the most important symptom, registered in 7% of patients under placebo and 12% in patients under treatment. The tolerance was considered good for 98% of patients. CONCLUSION: The association of captopril with hydrochlorothiazide is effective with good tolerance, being indicated as a once a day monotherapy for mild and moderate hypertension.

  • captopril
  • hydrochlorothiazide
  • Hypertension
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31/01/2007 DOI: 10.1590/S0066-782X1998001100012
Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients
ABC
Artigo Original

Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients

Renato J. Alves et al. Jayme Diament Rosângela F. Amâncio Neusa Forti Raul C. Maranhão

OBJECTIVE: To assess the effect of captopril, an angiotensin-converting enzyme inhibitor, on the metabolism of chylomicrons and their remnants and the possible alterations in the concentrations of plasma lipids caused by the drug in hypertensive hypercholesterolemic individuals. METHODS: The metabolism of chylomicrons was tested with the method of artificial lipid emulsion of chylomicrons labeled with ³H-cholesteryl oleate. The emulsion was injected intravenously in 10 patients with mild-moderate arterial hypertension before and 45 days after treatment with captopril (50 mg/day). After injection, blood samples were collected during 60 minutes at pre-established time intervals for determining the decay curve, the fractional catabolic rate (FCR in min-1), and the plasma residence time of the artificial lipid emulsion by analyzing different compartments. The plasma concentrations of the lipids were also assessed before and after treatment. RESULTS: The fractional catabolic rate (min-1) of the lipid emulsion before and after treatment with captopril (0.012±0.003 and 0.011±0.003, respectively; p=0.85, n.s.) and the plasma residence time of the emulsion (83.3±20.8 and 90.9±22.5 min, n.s.) did not change, but the total cholesterol and LDL-C levels decreased by 7% and 10%, respectively (p=0.02). The concentrations of HDL-C, triglycerides, Lp(a), and apolipoproteins AI and B did not change. CONCLUSION: Treatment with captopril, evaluated with the artificial lipid emulsion method, does not cause deleterious changes in the metabolism of chylomicrons and their remnants.

  • captopril
  • chylomicrons
  • Lipoproteins
  • Metabolism
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07/01/2005 DOI: 10.1590/S0066-782X2004001800009
ABC
Original Article

Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients

Cristiano Ricardo Bastos de Macedo et al. Antonio Carlos Beisl Noblat Lúcia de Araújo Costa Beisl Noblat Jeane Meire Sales de Macedo Antonio Alberto Lopes

OBJECTIVE: To evaluate the frequency of oral antihypertensive medication preceding the increase in blood pressure in patients in a university hospital, the drug of choice, and the maintained use of antihypertensive medication. METHODS: Data from January to June 1997 from the University Hospital Professor Edgard Santos Pharmacy concerning the prescriptions of all inpatients were used. Variables included in the analysis were: antihypertensive medication prescription preceding increase in blood pressure, type of antihypertensive medication, gender, clinical or surgical wards, and the presence of maintained antihypertensive medication. RESULTS: The hospital admitted 2,532 patients, 1,468 in surgical wards and 818 in medical wards. Antihypertensive medication prescription preceding pressure increase was observed in 578 patients (22.8%). Nifedipine was used in 553 (95.7%) and captopril in 25 (4.3%). In 50.7% of patients, prescription of antihypertensive medication was not associated with maintained antihypertensive medication. Prescription of antihypertensive drugs preceding elevation of blood pressure was significantly (p<0.001) more frequent on the surgical floor (27.5%; 405/1468) than on the medical floor (14.3%; 117/818). The frequency of prescription of antihypertensive drugs preceding elevation of blood pressure without maintained antihypertensive drugs and the ratio between the number of prescriptions of nifedipine and captopril were greater in surgical wards. CONCLUSION: The use of antihypertensive medication, preceding elevation of blood pressure (22.8%) observed in admitted patients is not supported by scientific evidence. The high frequency of this practice may be even greater in nonuniversity hospitals.

  • captopril
  • Hypertension
  • nifedipine
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28/11/2001 DOI: 10.1590/S0066-782X2001001000002 Views 2

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Oliveira MG, Noblat ACB, Noblat L, Passos LC. Analysis of the prescription of captopril to hospitalized patients. Arquivos Brasileiros de Cardiologia 2009;91(6):415-7.

Electronic Document Format (ABNT)

Oliveira, Márcio Galvão; Noblat, Antônio Carlos Beisl; Noblat, Lúcia; Passos, Luiz Carlos. Analysis of the prescription of captopril to hospitalized patients. Arquivos Brasileiros de Cardiologia, v. 91, n. 6, p. 415-417, Jan. 2009.

Electronic Document Format (APA)

Oliveira, M. G., Noblat, A. C. B., Noblat, L., & Passos, L. C. (2009). Analysis of the prescription of captopril to hospitalized patients. Arquivos Brasileiros de Cardiologia, 91(6), 415-417.

Electronic Document Format (ISO)

Oliveira, Márcio Galvão and Noblat, Antônio Carlos Beisl and Noblat, Lúcia and Passos, Luiz Carlos. Analysis of the prescription of captopril to hospitalized patients. Arquivos Brasileiros de Cardiologia [online]. 2009, vol. 91, n. 6, [cited 2026-10-14], pp. 415-417. Available from: <https://journals.cardiol.br/en/article/analysis-of-the-prescription-of-captopril-to-hospitalized-patients/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Santello JL, Mion Jr D. Association of captopril and hydrochlorothiazide in mild and moderate hypertension. Arquivos Brasileiros de Cardiologia 2007;71(5):713-6.

Electronic Document Format (ABNT)

Santello, José Luiz; Mion Jr, Décio. Association of captopril and hydrochlorothiazide in mild and moderate hypertension. Arquivos Brasileiros de Cardiologia, v. 71, n. 5, p. 713-716, Jan. 2007.

Electronic Document Format (APA)

Santello, J. L., & Mion Jr, D. (2007). Association of captopril and hydrochlorothiazide in mild and moderate hypertension. Arquivos Brasileiros de Cardiologia, 71(5), 713-716.

Electronic Document Format (ISO)

Santello, José Luiz and Mion Jr, Décio. Association of captopril and hydrochlorothiazide in mild and moderate hypertension. Arquivos Brasileiros de Cardiologia [online]. 2007, vol. 71, n. 5, [cited 2026-10-14], pp. 713-716. Available from: <https://journals.cardiol.br/en/article/association-of-captopril-and-hydrochlorothiazide-in-mild-and-moderate-hypertension/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Alves RJ, Diament J, Amâncio RF, Forti N, Maranhão RC. Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients. Arquivos Brasileiros de Cardiologia 2005;83(6):508-11.

Electronic Document Format (ABNT)

Alves, Renato J.; Diament, Jayme; Amâncio, Rosângela F.; Forti, Neusa; Maranhão, Raul C.. Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients. Arquivos Brasileiros de Cardiologia, v. 83, n. 6, p. 508-511, Jan. 2005.

Electronic Document Format (APA)

Alves, R. J., Diament, J., Amâncio, R. F., Forti, N., & Maranhão, R. C. (2005). Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients. Arquivos Brasileiros de Cardiologia, 83(6), 508-511.

Electronic Document Format (ISO)

Alves, Renato J. and Diament, Jayme and Amâncio, Rosângela F. and Forti, Neusa and Maranhão, Raul C.. Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients. Arquivos Brasileiros de Cardiologia [online]. 2005, vol. 83, n. 6, [cited 2026-10-14], pp. 508-511. Available from: <https://journals.cardiol.br/article/lack-of-effect-of-captopril-on-the-metabolism-of-an-artificial-lipid-emulsion-similar-to-chylomicrons-in-hypertensive-hypercholesterolemic-patients/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Macedo CRB, Noblat ACB, Noblat LACB, Macedo JMS, Lopes AA. Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients. Arquivos Brasileiros de Cardiologia 2001;77(4):328-31.

Electronic Document Format (ABNT)

Macedo, Cristiano Ricardo Bastos de; Noblat, Antonio Carlos Beisl; Noblat, Lúcia de Araújo Costa Beisl; Macedo, Jeane Meire Sales de; Lopes, Antonio Alberto. Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients. Arquivos Brasileiros de Cardiologia, v. 77, n. 4, p. 328-331, Nov. 2001.

Electronic Document Format (APA)

Macedo, C. R. B. , Noblat, A. C. B., Noblat, L. A. C. B., Macedo, J. M. S. , & Lopes, A. A. (2001). Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients. Arquivos Brasileiros de Cardiologia, 77(4), 328-331.

Electronic Document Format (ISO)

Macedo, Cristiano Ricardo Bastos de and Noblat, Antonio Carlos Beisl and Noblat, Lúcia de Araújo Costa Beisl and Macedo, Jeane Meire Sales de and Lopes, Antonio Alberto. Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients. Arquivos Brasileiros de Cardiologia [online]. 2001, vol. 77, n. 4, [cited 2026-10-14], pp. 328-331. Available from: <https://journals.cardiol.br/en/article/use-of-oral-antihypertensive-medication-preceding-blood-pressure-elevation-in-hospitalized-patients/>. ISSN 0066-782X

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