Biomarkers/blood – ABC CARDIOL

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Editorial

Takotsubo Syndrome: A Recurrent Disease?

Fábio Fernandes et al. Marcelo Westmoreland Montera

Several terms (such as happy heart syndrome, broken heart syndrome, and takotsubo cardiomyopathy) have been used to refer to the recently defined Takotsubo Syndrome (TTS). The first case of TTS was described in Japan (Hiroshima City Hospital) in 1983 and a report of five cases was published in a Japanese medical textbook in 1990.

However, in contrast to other cardiomyopathies that are usually not transient in nature, TTS is characterized by a temporary wall motion abnormality of the LV in the absence of pheochromocytoma, myocarditis and shares common features with acute coronary syndrome (ACS) similar symptoms at presentation, ECG abnormalities, elevated cardiac biomarkers, as well as a comparable in-hospital mortality with ST-segment elevation myocardial infarction (STEMI) and non-STEMI, specifically in terms of a microvascular ACS form. The European Society of Cardiology (ESC) has also established the International Takotsubo Diagnostic Criteria (InterTAK Diagnostic Criteria), which implement a diagnostic algorithm and assign a score to TTS.

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Original Article

Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge

Asim Enhos et al. Kahraman Cosansu Mustafa Ahmet Huyut Fahrettin Turna … Erdem Karacop Nijad Bakshaliyev Aydin Nadir Ramazan Ozdemir Mahmut Uluganyan

Abstract

Background:

Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde.

Objective:

To evaluate the relationhip between MHR and the presence of MB.

Methods:

We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients’ angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant.

Results:

MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors.

Conclusion:

The present study revealed a significant correlation between MHR and MB.

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Editorial

Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome

José Mariani Junior

Inflammation is a complex and necessary component of the response to biological, chemical, or physical stimuli, and the cellular and molecular events that initiate and regulate the interactions between the various players in the inflammatory process of the atherosclerotic lesions remain a source of ongoing investigation.

The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis – Intravascular Ultrasound (ATHEROREMO-IVUS) study aimed to investigate the relations of genetic profile and novel circulating and inflammatory biomarkers with coronary plaque phenotype and vulnerability as determined by intravascular ultrasound (IVUS). Results from this trial have been helping us to improve our knowledge on the role of genetic profile and circulating inflammatory biomarkers in relation to the development of atherosclerosis and vulnerable plaques.

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Takotsubo Syndrome: A Recurrent Disease?

Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge

Abstract

Background:

Objective:

Methods:

Results:

Conclusion:

Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome

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