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  • Família ABC
  • Arquivos Brasileiros de Cardiologia
  • International Journal of Cardiovascular Sciences
  • ABC Heart Failure & Cardiomyopathy
  • ABC Imagem Cardiovascular
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  2. Palavra-chave: Aneurysm
IJCS
Case Report

Left Pulmonary Artery Aneurysm in an Adult Patient With Uncorrected Tetralogy of Fallot and Patent Ductus Arteriosus: A Case Report

Miguel Bernardino Antunes Vicente et al. Elsa Fernandes Roger Dopico Luis Mariano … Odete Mingas Domingos Ramos Lino Gonçalves

Abstract

The authors describe a case of an infrequent triple association: left pulmonary artery aneurysm (PAA), uncorrected tetralogy of Fallot (TOF) and patent ductus arteriosus (PDA), diagnosed in a 45-year-old adult patient during a check-up. The patient refused to undergo surgery and is currently being followed clinically.

  • Aneurysm
  • Pulmonary Artery
  • Tetralogy of Fallot
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Creative Commons Attribution (CC BY) Creative Commons license
16/06/2025 DOI: 10.36660/ijcs.20240249
ABC
Original Article

Comparison between Adventitial and Intimal Inflammation of Ruptured and Nonruptured Atherosclerotic Plaques in Human Coronary Arteries

Maria L. Higuchi et al. Paulo S. Gutierrez Hiram G. Bezerra Suely A. Palomino … Vera D. Aiello Júlia M. L. Silvestre Peter Libby José A. F. Ramires

OBJECTIVE: To verify the possible role of adventitial inflammation in atherosclerotic plaque vulnerability and coronary artery remodelling. METHODS: We compared the mean numbers of lymphocytes in the adventitia and in the plaque of ruptured thrombosed and stable equi-stenotic coronary segments of 34 patients who died due to acute myocardial infarction. We also analysed adventitial microvessels, adventitial fibrosis and the external elastic membrane. RESULTS: In the adventitia, the numbers of lymphocytes and microvessels/mm² were 69.5±88.3 and 60.9± 32.1 in culprit lesions and 16.4 ± 21.1 and 44.3±16.1 in stable lesions (p<0.05); within the plaques, the mean number of lymphocytes was 24±40.8 in culprit lesions and 10.9±13.2 in stable ones (p=0.17). The mean percent area of adventitial fibrosis/cross-sectional area of the vessel was significantly lower in unstable plaques (p<0.001). The confocal images showed holes in the external elastic membrane. CONCLUSION: Unstable plaques exhibit chronic pan-arteritis, accompanied by enlargement, medial thinning, and less fibrosis than in stable lesions, which is compatible with vessel aneurysm. Adventitial inflammation may contribute significantly to atheroma instability.

  • adventitial inflammation
  • Aneurysm
  • arteritis
  • coronary atherosclerosis
  • unstable plaques
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Creative Commons Attribution (CC BY) Creative Commons license
01/08/2002 DOI: 10.1590/S0066-782X2002001000003

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Vicente MBA, Fernandes E, Dopico R, Mariano L, Mingas O, Ramos D, Gonçalves L, et al. Left Pulmonary Artery Aneurysm in an Adult Patient With Uncorrected Tetralogy of Fallot and Patent Ductus Arteriosus: A Case Report. International Journal of Cardiovascular Sciences 2025;38:e20240249.

Formato de Documento Eletrônico (ABNT)

Vicente, Miguel Bernardino Antunes; Fernandes, Elsa; Dopico, Roger; Mariano, Luis; Mingas, Odete; Ramos, Domingos; Gonçalves, Lino. Left Pulmonary Artery Aneurysm in an Adult Patient With Uncorrected Tetralogy of Fallot and Patent Ductus Arteriosus: A Case Report. International Journal of Cardiovascular Sciences, v. 38, e20240249, jun. 2025.

Formato de Documento Eletrônico (APA)

Vicente, M. B. A., Fernandes, E., Dopico, R., Mariano, L., Mingas, O., Ramos, D., & Gonçalves, L. (2025). Left Pulmonary Artery Aneurysm in an Adult Patient With Uncorrected Tetralogy of Fallot and Patent Ductus Arteriosus: A Case Report. International Journal of Cardiovascular Sciences, 38, e20240249.

Formato de Documento Eletrônico (ISO)

Vicente, Miguel Bernardino Antunes and Fernandes, Elsa and Dopico, Roger and Mariano, Luis and Mingas, Odete and Ramos, Domingos and Gonçalves, Lino. Left Pulmonary Artery Aneurysm in an Adult Patient With Uncorrected Tetralogy of Fallot and Patent Ductus Arteriosus: A Case Report. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-10-14], e20240249. Disponível em: <https://journals.cardiol.br/article/left-pulmonary-artery-aneurysm-in-an-adult-patient-with-uncorrected-tetralogy-of-fallot-and-patent-ductus-arteriosus-a-case-report-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Higuchi ML, Gutierrez PS, Bezerra HG, Palomino SA, Aiello VD, Silvestre JML, Libby P, et al. Comparison between Adventitial and Intimal Inflammation of Ruptured and Nonruptured Atherosclerotic Plaques in Human Coronary Arteries. Arquivos Brasileiros de Cardiologia 2002;79(1):20-4.

Formato de Documento Eletrônico (ABNT)

Higuchi, Maria L.; Gutierrez, Paulo S.; Bezerra, Hiram G.; Palomino, Suely A.; Aiello, Vera D.; Silvestre, Júlia M. L.; Libby, Peter; Ramires, José A. F.. Comparison between Adventitial and Intimal Inflammation of Ruptured and Nonruptured Atherosclerotic Plaques in Human Coronary Arteries. Arquivos Brasileiros de Cardiologia, v. 79, n. 1, p. 20-24, jul. 2002.

Formato de Documento Eletrônico (APA)

Higuchi, M. L., Gutierrez, P. S., Bezerra, H. G., Palomino, S. A., Aiello, V. D., Silvestre, J. M. L., Libby, P., & Ramires, J. A. F. (2002). Comparison between Adventitial and Intimal Inflammation of Ruptured and Nonruptured Atherosclerotic Plaques in Human Coronary Arteries. Arquivos Brasileiros de Cardiologia, 79(1), 20-24.

Formato de Documento Eletrônico (ISO)

Higuchi, Maria L. and Gutierrez, Paulo S. and Bezerra, Hiram G. and Palomino, Suely A. and Aiello, Vera D. and Silvestre, Júlia M. L. and Libby, Peter and Ramires, José A. F.. Comparison between Adventitial and Intimal Inflammation of Ruptured and Nonruptured Atherosclerotic Plaques in Human Coronary Arteries. Arquivos Brasileiros de Cardiologia [online]. 2002, vol. 79, n. 1, [citado 2026-10-14], pp. 20-24. Disponível em: <https://journals.cardiol.br/article/comparison-between-adventitial-and-intimal-inflammation-of-ruptured-and-nonruptured-atherosclerotic-plaques-in-human-coronary-arteries-2/>. ISSN 0066-782X

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