Serving Two Masters: Resolving the Dilemma between Individual Patient Data Meta-Analysis and Aggregate Data Meta-Analysis from Statin Trials
Introduction
Elevated levels of low-density lipoprotein-cholesterol (LDL-C) have been established as an important risk factor for the development of atherosclerosis. As a corollary of this reasoning, an LDL-centric approach has emerged based on statins and other medications able to reduce LDL-C and cardiovascular risk.
The Cholesterol Treatment Trialists’ Collaboration, an individual patient data meta-analysis, found a log-linear relationship between the degree of LDL-C reduction and cardiovascular events. According to this, expert guidelines for preventing cardiovascular diseases recommend statin use for primary and secondary prevention.
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