Amyloidosis: Rare or Underdiagnosed Disease?

Transthyretin amyloidosis

Transthyretin amyloidosis (ATTR) is caused by the deposition of transthyretin (TTR), a protein synthesized by the liver, which has a stable tetrameric structure and whose function is the transport of thyroid hormones and retinol. TTR can dissociate into monomers and oligomers and then be deposited as amyloid fibrils, in a natural (wtATTR or “wild type”, previously known as senile systemic amyloidosis) or genetic manner (hATTR or “hereditary”).

The number of patients diagnosed with ATTR has increased over the years, and it has come to be considered that it may be more prevalent than AL.

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