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  2. Keyword: Lipoprotein lipase mutations
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The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids

Kátia A. Almeida et al. Célia M. C. Strunz Raul C. Maranhão Antonio P. Mansur

OBJECTIVE: The objective of this study was to evaluate the effect of polymorphism S447X on plasma lipids of patients with premature coronary artery disease (CAD). METHODS: Plasma lipids and genotypes were determined in 2 groups: 313 patients with premature CAD (<55 years of age) and 150 controls without CAD. RESULTS: Frequency of the S447X polymorphism was 18% in patients with CAD and 23% in the control group. The S447X polymorphism of lipoprotein lipase is related to a decrease in plasma triglyceride concentrations in male patients with CAD, but this correlation is not observed in female patients. CONCLUSION: The presence of the S447X lipoprotein lipase polymorphism was not associated with the incidence of CAD.

  • Cholesterol
  • Lipoprotein lipase mutations
  • Lipoproteins
  • Triglycerides
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Creative Commons Attribution (CC BY) Creative Commons license
21/05/2007 DOI: 10.1590/S0066-782X2007000300008 Views 2

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Electronic Document Format (Vancouver)

Almeida KA, Strunz CMC, Maranhão RC, Mansur AP. The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. Arquivos Brasileiros de Cardiologia 2007;88(3):297-303.

Electronic Document Format (ABNT)

Almeida, Kátia A.; Strunz, Célia M. C.; Maranhão, Raul C.; Mansur, Antonio P.. The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. Arquivos Brasileiros de Cardiologia, v. 88, n. 3, p. 297-303, May. 2007.

Electronic Document Format (APA)

Almeida, K. A., Strunz, C. M. C., Maranhão, R. C., & Mansur, A. P. (2007). The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. Arquivos Brasileiros de Cardiologia, 88(3), 297-303.

Electronic Document Format (ISO)

Almeida, Kátia A. and Strunz, Célia M. C. and Maranhão, Raul C. and Mansur, Antonio P.. The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. Arquivos Brasileiros de Cardiologia [online]. 2007, vol. 88, n. 3, [cited 2026-10-14], pp. 297-303. Available from: <https://journals.cardiol.br/en/article/the-s447x-polymorphism-of-lipoprotein-lipase-effect-on-the-incidence-of-premature-coronary-disease-and-on-plasma-lipids/>. ISSN 0066-782X

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