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Research Letter

Cumulative Disorder of Myocardial Lipofuscin after Long-Term Heart Transplantation: A Study Based on Endomyocardial Biopsies

Luiz Alberto Benvenuti et al. Fabiana G. Marcondes-Braga Fernando Bacal

Introduction

Lipofuscin is a yellowish-brown, non-degradable cytoplasmic pigment composed of highly oxidized proteins, lipids, and metals. Lipofuscin accumulates over time in perennial post-mitotic cells such as cardiomyocytes and is also called “age pigment”.^–

Heart transplantation is an established treatment for patients with severe heart failure refractory to other forms of treatment. Its major long-term limitation is the development of cardiac allograft vasculopathy (CAV), which is relatively difficult to diagnose and for which few effective treatment options exist.^6,7 In this context, it is worth mentioning a previous study relating the amount of lipofuscin in the myocardium of heart transplant patients to the development of CAV.

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Artigo Original

Myocardial morphometry of protein-energy malnourished adults

Daniel Ferreira da Cunha et al. Cristiane Helena Pedrini Júlio Cláudio Sousa Marlene Antônia dos Reis … Sidney Gonçalves Ramos Selma Freire de Carvalho da Cunha Vicente de Paula Antunes Teixeira

PURPOSE: To compare cardiac muscle cells width and cardiomyocyte lipofuscin pigment presence between malnourished and non-malnourished necropsied adults. METHODS: Out of 315 necropsy protocols of adults randomly chosen, those with edema, ascitis, systemic arterial hypertension, chronic liver disease, and heart disease were excluded. Malnutrition was defined by body mass index (BMI) <17kg/m². Cardiomyocytes morphometry study and lipofuscin pigment counts were performed. RESULTS: Malnourished (n=8) and controls (n=4), respectively, showed statistical differences in relation to BMI (14.86±1.13 vs 22.02±0.9kg/m²), heart weight/body weight ratio (0.68±0.09 vs 0.54±0.07%), cardiomyocytes width (10.91±0.77 vs 12.90±1.82µm) and lipofuscin pigment presence (39.1 vs 54.4%). CONCLUSION: When compared with controls, necropsied malnourished adults showed decreased myocardial fibers diameters and lower lipofuscin pigment presence. These findings might reflect altered metabolism, and would be associated with harmful clinical effects in terminally ill patients.

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Cumulative Disorder of Myocardial Lipofuscin after Long-Term Heart Transplantation: A Study Based on Endomyocardial Biopsies

Introduction

Myocardial morphometry of protein-energy malnourished adults

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Electronic Document Format (Vancouver)

Electronic Document Format (ABNT)

Electronic Document Format (APA)

Electronic Document Format (ISO)