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  2. Keyword: disease progression
Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?
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Review Article

Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?

Paul Schoenhagen et al. E. Murat Tuzcu

CAD remains a major global cause of morbidity and mortality. Comprehensive drug development programs of novel pharmacological treatment strategies frequently utilize traditional mortality/morbidity endpoints studies and additional surrogate endpoints trials. This parallel approach allows an assessment of efficacy several years in advance of the availability of data from clinical endpoint trials. Several atherosclerosis imaging markers have been introduced into these drug-development strategies, including angiography, carotid ultrasound, IVUS, MRI, and CT. This review will discuss the current status of atherosclerosis imaging as an endpoint in progression/regression trials, with an emphasis on evidence-based data. In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented.

  • Atherosclerosis
  • Coronary Diseases
  • Diagnostic Imaging
  • disease progression
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Creative Commons Attribution (CC BY) Creative Commons license
05/01/2009 DOI: 10.1590/S0066-782X2008001800010 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Schoenhagen P, Tuzcu EM. Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?. Arquivos Brasileiros de Cardiologia 2009;91(6):418-31.

Electronic Document Format (ABNT)

Schoenhagen, Paul; Tuzcu, E. Murat. Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?. Arquivos Brasileiros de Cardiologia, v. 91, n. 6, p. 418-431, Jan. 2009.

Electronic Document Format (APA)

Schoenhagen, P., & Tuzcu, E. M. (2009). Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?. Arquivos Brasileiros de Cardiologia, 91(6), 418-431.

Electronic Document Format (ISO)

Schoenhagen, Paul and Tuzcu, E. Murat. Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?. Arquivos Brasileiros de Cardiologia [online]. 2009, vol. 91, n. 6, [cited 2026-10-14], pp. 418-431. Available from: <https://journals.cardiol.br/en/article/atherosclerosis-imaging-in-progression-regression-trials-surrogate-marker-or-direct-window-into-the-atherosclerotic-disease-process/>. ISSN 0066-782X

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