Família ABC Arquivos Brasileiros de Cardiologia International Journal of Cardiovascular Sciences ABC Heart Failure & Cardiomyopathy ABC Imagem Cardiovascular
Português English
Família ABC
Português English
  • Sobre
    • Sobre a Família ABC
    • Regimento Interno
    • Conselho Editorial
    • Sociedade Brasileira de Cardiologia (SBC)
  • Edições
  • Diretrizes da SBC
  • Conteúdos
    • Vídeos
    • Podcasts
    • Notícias
  • Sobre
    • Sobre a Família ABC
    • Regimento Interno
    • Conselho Editorial
    • Sociedade Brasileira de Cardiologia (SBC)
  • Edições
  • Diretrizes da SBC
  • Conteúdos
    • Vídeos
    • Podcasts
    • Notícias

Família ABC

  • Família ABC
  • Arquivos Brasileiros de Cardiologia
  • International Journal of Cardiovascular Sciences
  • ABC Heart Failure & Cardiomyopathy
  • ABC Imagem Cardiovascular
Buscar em

Nenhum conteúdo encontrado.

Revistas
Ordenação
Tipos de artigo
Outros

  1. Início
  2. Palavra-chave: losartan
ABC
Original Article

Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan

Antônio Carlos Avanza Jr et al. Lilian Mameri El Aouar José Geraldo Mill

OBJECTIVE: To compare the regression of left ventricular hypertrophy in patients with moderate hypertension treated with enalapril, losartan or a combination of the two drugs at lower doses. METHODS: Patients of both sexes with moderate hypertension confirmed by ambulatory monitoring of arte-rial blood pressure and with left ventricular hypertrophy on echocardiogram were assigned to three groups: enalapril (35 mg/day, n=15), losartan (175 mg/day, n=15) and enalapril+losartan (15 mg+100 mg/day, n=16). The patients received the drugs for 10 months. RESULTS: The three therapeutic regimens were equally effective in reducing blood pressure and left ventricular mass index (LVMI, g/m²): 141±3.9 to 123±3.6 in the enalapril group (p<0.05), from 147±3.8 to 133±2.8 in the losartan group (p<0.05), and from 146±3.0 to 116±4.0 in the enalapril+losartan group (p<0.05). However, the percent reduction of LVMI was significantly greater (p<0.01) in the enalapril+losartan group (20.5±5.0%) than in enalapril (12.4±3.2%) and the losartan (9.1±2.1%) groups. Normalization of LVMI was obtained in 10 out of the 16 patients who received enalapril+ losartan, in 6 out of the 15 patients who received only enalapril and in 4 out of the 15 patients treated with losartan. CONCLUSION: The combination of an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist (AT1 receptor antagonist) in patients produced an additional effect on the reduction of left ventricular hypertrophy. This finding may depend on a more complete inhibition of the cardiac renin-angiotensin.

  • angiotensin-converting enzyme
  • cardiac hypertrophy
  • Hypertension
  • losartan
  • renin-angiotensin system
Ler artigo completo
Creative Commons Attribution (CC BY) Creative Commons license
05/09/2000 DOI: 10.1590/S0066-782X2000000200001

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Avanza Jr AC, Aouar LME, Mill JG. Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan. Arquivos Brasileiros de Cardiologia 2000;74(2):111-7.

Formato de Documento Eletrônico (ABNT)

Avanza Jr, Antônio Carlos; Aouar, Lilian Mameri El; Mill, José Geraldo. Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan. Arquivos Brasileiros de Cardiologia, v. 74, n. 2, p. 111-117, set. 2000.

Formato de Documento Eletrônico (APA)

Avanza Jr, A. C., Aouar, L. M. E., & Mill, J. G. (2000). Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan. Arquivos Brasileiros de Cardiologia, 74(2), 111-117.

Formato de Documento Eletrônico (ISO)

Avanza Jr, Antônio Carlos and Aouar, Lilian Mameri El and Mill, José Geraldo. Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan. Arquivos Brasileiros de Cardiologia [online]. 2000, vol. 74, n. 2, [citado 2026-10-14], pp. 111-117. Disponível em: <https://journals.cardiol.br/article/reduction-in-left-ventricular-hypertrophy-in-hypertensive-patients-treated-with-enalapril-losartan-or-the-combination-of-enalapril-and-losartan-2/>. ISSN 0066-782X

  • Sobre a Família ABC
  • Regimento Interno
  • Conselho Editorial
  • Sociedade Brasileira de Cardiologia (SBC)

Edições

Diretrizes da SBC

  • Vídeos
  • Podcasts
  • Notícias