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  • Família ABC
  • Arquivos Brasileiros de Cardiologia
  • International Journal of Cardiovascular Sciences
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  • ABC Imagem Cardiovascular
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  2. Palavra-chave: inotropic agents
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Original Article

Assessment of inotropic and vasodilating effects of milrinone lactate in patients with dilated cardiomyopathy and severe heart failure

Edson Antonio Bregagnollo et al. Adjair Humberto Fortes Antonio Carlos Cicogna

OBJECTIVE: To assess the hemodynamic and vasodilating effects of milrinone lactate (ML) in patients with dilated cardiomyopathy (DCM) and New York Heart Association (NYHA) class III and IV heart failure. METHODS: Twenty patients with DCM and NYHA class III and IV heart failure were studied. The hemodynamic and vasodilating effects of ML, administered intravenously, were evaluated. The following variables were compared before and during drug infusion: cardiac output (CO) and cardiac index (CI); pulmonary capillary wedge pressure (PCWP); mean aortic pressure (MAP); mean pulmonary artery pressure (MPAP); mean right atrial pressure (MRAP); left ventricular systolic and end-diastolic pressures (LVSP and LVEDP, respectively); peak rate of left ventricular pressure rise (dP/dt); systemic vascular resistance (SVR); pulmonary vascular resistance (PVR); and heart rate (HR). RESULTS: All patients showed a significant improvement of the analysed parameters of cardiac performance with an increase of CO and CI; a significant improvement in myocardial contractility (dP/dt) and reduction of the LVEDP; PCWP; PAP; MAP; MRAP; SVR; PVR. Were observed no significant increase in HR occurred. CONCLUSION: Milrinone lactate is an inotropic dilating drug that, when administered intravenously, has beneficial effects on cardiac performance and myocardial contractility. It also promotes reduction of SVR and PVR in patients with DCM and NYHA class III and IV of heart failure.

  • Heart Failure
  • inotropic agents
  • Milrinone
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Creative Commons Attribution (CC BY) Creative Commons license
08/01/2002 DOI: 10.1590/S0066-782X1999000200003

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Formato de Documento Eletrônico (Vancouver)

Bregagnollo EA, Fortes AH, Cicogna AC. Assessment of inotropic and vasodilating effects of milrinone lactate in patients with dilated cardiomyopathy and severe heart failure. Arquivos Brasileiros de Cardiologia 2002;72(2):149-60.

Formato de Documento Eletrônico (ABNT)

Bregagnollo, Edson Antonio; Fortes, Adjair Humberto; Cicogna, Antonio Carlos. Assessment of inotropic and vasodilating effects of milrinone lactate in patients with dilated cardiomyopathy and severe heart failure. Arquivos Brasileiros de Cardiologia, v. 72, n. 2, p. 149-160, jan. 2002.

Formato de Documento Eletrônico (APA)

Bregagnollo, E. A., Fortes, A. H., & Cicogna, A. C. (2002). Assessment of inotropic and vasodilating effects of milrinone lactate in patients with dilated cardiomyopathy and severe heart failure. Arquivos Brasileiros de Cardiologia, 72(2), 149-160.

Formato de Documento Eletrônico (ISO)

Bregagnollo, Edson Antonio and Fortes, Adjair Humberto and Cicogna, Antonio Carlos. Assessment of inotropic and vasodilating effects of milrinone lactate in patients with dilated cardiomyopathy and severe heart failure. Arquivos Brasileiros de Cardiologia [online]. 2002, vol. 72, n. 2, [citado 2026-10-14], pp. 149-160. Disponível em: <https://journals.cardiol.br/article/assessment-of-inotropic-and-vasodilating-effects-of-milrinone-lactate-in-patients-with-dilated-cardiomyopathy-and-severe-heart-failure-2/>. ISSN 0066-782X

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