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  1. Início
  2. Palavra-chave: Cardiotoxicity
IJCS
Editorial

Anabolic-Androgenic Steroids and Cardiotoxicity

José Antônio Caldas Teixeira et al. Joelma Dominato Rocha Carvalho Mateus Freitas Teixeira

Anabolic-androgenic steroids (AAS) are a class of natural and synthetic hormones, which owe their name to their chemical structure (steroid nucleus) and their biological, anabolic, and androgenic effects. Misuse of AAS for aesthetic and performance purposes has become widespread, as they provide increases in muscle mass and strength. It is estimated that approximately 3.5% of the world’s population uses AAS.

Use of AAS dates back to ancient Greece, followed by the Second World War. They were detected in sports competitions in 1954 and later disseminated among bodybuilders and identified in various sports in the Tokyo 1964 Olympic Games. Currently, we are witnessing a growing encouragement of AAS use for aesthetic purposes, through “beauty chips” and disguised as hormone replacement therapy. This indiscriminate use culminated in a resolution by the Brazilian Federal Council of Medicine against the prescription of these hormones for aesthetic purposes.

[…]

  • Anabolic Androgenic Steroids
  • Androgens
  • Cardiotoxicity
  • Steroids
  • Testosterone
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Creative Commons Attribution (CC BY) Creative Commons license
15/08/2025 DOI: 10.36660/ijcs.20250096 Visualizações 1
IJCS
Review Article

Cardiovascular Disease in Women With Breast Cancer: A Contemporary Review

Adriana Puente Barragán et al. Patricia Nuriulú Escobar Alejandra Madrid Miller Luis Antonio Moreno Ruiz

Abstract

Breast cancer (BC) is the most common malignant neoplasia in women and is responsible for one in six deaths from cancer in the female population. Five years after diagnosis, BC survival rates currently exceed 80%. Cardiovascular disease (CVD) is a frequent cause of morbidity and mortality in BC, mainly in patients receiving cardiotoxic drugs (anthracyclines, immunotherapy) and radiotherapy (RT).

CVD and BC have common risk factors (RF), which are related to aging, traditional and cardiometabolic RFs (obesity, dyslipidemia, consumption of alcoholic beverages), and others associated with sex and reproductive women’s age, such as early menarche, late menopause, nulliparity, use of oral contraceptives, as well as hormone replacement therapy in postmenopause.

Risk stratification and the promotion of an ideal state of cardiovascular (CV) health are fundamental in preventing CVD in survivors. Therapeutic management and follow-up of patients with BC require a multidisciplinary team to reduce complications and mortality of CV origin.

  • Breast Neoplasms
  • Cardiotoxicity
  • cardiovascular diseases
  • Women
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Creative Commons Attribution (CC BY) Creative Commons license
12/02/2024 DOI: 10.36660/ijcs.20230131 Visualizações 1
IJCS
Editorial

Can Exercise Training Prevent Doxorubicin-induced Cardiomyopathy?

Marcus Vinicius Machado et al. Ronan Chapuis Aline Bomfim Vieira

Doxorubicin (DOX) is a cytotoxic antineoplastic agent of the anthracycline family. It has been used as the first-line chemotherapy drug for treating various types of cancer, such as breast, lung and bladder cancer, and lymphoblastic leukemia. As any anthracycline, DOX is an effective chemotherapeutic drug. However, it holds a potentially lethal dose-dependent cardiovascular toxicity, which can manifest immediately or many years after chemotherapy, limiting its clinical application.

After the discontinuation of DOX treatment, a seven-year follow-up of 1,807 patients reported 33% death from heart diseases. Similarly, a 7.5% incidence of some cardiomyopathies was reported in pediatric sarcoma patients within an average of 34 months post-DOX treatment.

[…]

  • Cardiotoxicity
  • Doxorubicin
  • exercise
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Creative Commons Attribution (CC BY) Creative Commons license
28/11/2022 DOI: 10.36660/ijcs.20220170 Visualizações 2
IJCS
Original Article

Physical Training Improves Cardiac Structure and Function of Rats After Doxorubicin-Induced Cardiomyopathy

Fernanda Rodrigues Souza et al. Érica Carolina Campos Leandro Teixeira Paranhos Lopes Clesnan Mendes Rodrigues … Danilo Lemes Naves Gonçalves Marcelo Emílio Beletti Matheus Matioli Mantovani Poliana Rodrigues Alves Duarte Alexandre Gonçalves Elmiro Santos Resende

Abstract

Background:

The use of doxorubicin in chemotherapy has been associated with cardiotoxicity and heart failure. Physical exercise produces favorable morphofunctional adaptations in the cardiovascular system and may reverse cardiac dysfunction in patients undergoing chemotherapy.

Objective:

To assess the effects of physical training on myocardial structure, cardiac function, and exercise tolerance in Wistar rats initiated after the onset of cardiotoxicity-induced cardiotoxicity.

Methods:

This study investigated 30 adult male Wistar rats randomly divided into four groups: control (C), exercise (EX), doxorubicin (DX), and doxorubicin and exercise (DXEX). The DX and DXEX groups received six doses of doxorubincin from 1.25 mg/kg body weight up to a cumulative dose of 7.5 mg/kg. Injections were administered intraperitoneally three times a week for two weeks; after this stage, the EX and DXEX groups started physical training (swimming) sessions three times a week with a load of 5% of their body weight. Echocardiography and exercise tolerance tests were performed. Generalized linear models were used in statistical analysis, and a p<0.05 was set as statistically significant.

Results:

Left ventricular shortening fraction and ejection fraction were reduced in the DX group compared to C, EX, and DXEX. The DXEX group showed greater tolerance to effort when compared to the DX and C groups.

Conclusion:

Physical training, initiated after the onset of doxorubicin-induced cardiotoxicity, improved cardiac function and exercise tolerance in rats.

  • Anthracyclines
  • Cardiotoxicity
  • Echocardiography
  • exercise
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Creative Commons Attribution (CC BY) Creative Commons license
30/05/2022 DOI: 10.36660/ijcs.20210095 Visualizações 1

Como citar este artigo

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Teixeira JAC, Carvalho JDR, Teixeira MF. Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences 2025;38:e20250096.

Formato de Documento Eletrônico (ABNT)

Teixeira, José Antônio Caldas; Carvalho, Joelma Dominato Rocha; Teixeira, Mateus Freitas. Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences, v. 38, e20250096, ago. 2025.

Formato de Documento Eletrônico (APA)

Teixeira, J. A. C., Carvalho, J. D. R., & Teixeira, M. F. (2025). Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences, 38, e20250096.

Formato de Documento Eletrônico (ISO)

Teixeira, José Antônio Caldas and Carvalho, Joelma Dominato Rocha and Teixeira, Mateus Freitas. Anabolic-Androgenic Steroids and Cardiotoxicity. International Journal of Cardiovascular Sciences [online]. 2025, vol. 38, [citado 2026-10-14], e20250096. Disponível em: <https://journals.cardiol.br/article/anabolic-androgenic-steroids-and-cardiotoxicity-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Barragán AP, Escobar PN, Miller AM, Ruiz LAM. Cardiovascular Disease in Women With Breast Cancer: A Contemporary Review. International Journal of Cardiovascular Sciences 2024;37:e20230131.

Formato de Documento Eletrônico (ABNT)

Barragán, Adriana Puente; Escobar, Patricia Nuriulú; Miller, Alejandra Madrid; Ruiz, Luis Antonio Moreno. Cardiovascular Disease in Women With Breast Cancer: A Contemporary Review. International Journal of Cardiovascular Sciences, v. 37, e20230131, fev. 2024.

Formato de Documento Eletrônico (APA)

Barragán, A. P., Escobar, P. N., Miller, A. M., & Ruiz, L. A. M. (2024). Cardiovascular Disease in Women With Breast Cancer: A Contemporary Review. International Journal of Cardiovascular Sciences, 37, e20230131.

Formato de Documento Eletrônico (ISO)

Barragán, Adriana Puente and Escobar, Patricia Nuriulú and Miller, Alejandra Madrid and Ruiz, Luis Antonio Moreno. Cardiovascular Disease in Women With Breast Cancer: A Contemporary Review. International Journal of Cardiovascular Sciences [online]. 2024, vol. 37, [citado 2026-10-14], e20230131. Disponível em: <https://journals.cardiol.br/article/cardiovascular-disease-in-women-with-breast-cancer-a-contemporary-review-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Machado MV, Chapuis R, Vieira AB. Can Exercise Training Prevent Doxorubicin-induced Cardiomyopathy?. International Journal of Cardiovascular Sciences 2022;35(6):727-9.

Formato de Documento Eletrônico (ABNT)

Machado, Marcus Vinicius; Chapuis, Ronan; Vieira, Aline Bomfim. Can Exercise Training Prevent Doxorubicin-induced Cardiomyopathy?. International Journal of Cardiovascular Sciences, v. 35, n. 6, p. 727-729, nov. 2022.

Formato de Documento Eletrônico (APA)

Machado, M. V., Chapuis, R., & Vieira, A. B. (2022). Can Exercise Training Prevent Doxorubicin-induced Cardiomyopathy?. International Journal of Cardiovascular Sciences, 35(6), 727-729.

Formato de Documento Eletrônico (ISO)

Machado, Marcus Vinicius and Chapuis, Ronan and Vieira, Aline Bomfim. Can Exercise Training Prevent Doxorubicin-induced Cardiomyopathy?. International Journal of Cardiovascular Sciences [online]. 2022, vol. 35, n. 6, [citado 2026-10-14], pp. 727-729. Disponível em: <https://journals.cardiol.br/article/can-exercise-training-prevent-doxorubicin-induced-cardiomyopathy-2/>. ISSN 2359-4802

EndNote RIS

Formato de Documento Eletrônico (Vancouver)

Souza FR, Campos C, Lopes LTP, Rodrigues CM, Gonçalves DLN, Beletti ME, Mantovani MM, et al. Physical Training Improves Cardiac Structure and Function of Rats After Doxorubicin-Induced Cardiomyopathy. International Journal of Cardiovascular Sciences 2022;35(6):718-26.

Formato de Documento Eletrônico (ABNT)

Souza, Fernanda Rodrigues; Campos, Érica Carolina; Lopes, Leandro Teixeira Paranhos; Rodrigues, Clesnan Mendes; Gonçalves, Danilo Lemes Naves; Beletti, Marcelo Emílio; Mantovani, Matheus Matioli; Duarte, Poliana Rodrigues Alves; Gonçalves, Alexandre; Resende, Elmiro Santos. Physical Training Improves Cardiac Structure and Function of Rats After Doxorubicin-Induced Cardiomyopathy. International Journal of Cardiovascular Sciences, v. 35, n. 6, p. 718-726, maio. 2022.

Formato de Documento Eletrônico (APA)

Souza, F. R., Campos, C., Lopes, L. T. P., Rodrigues, C. M., Gonçalves, D. L. N., Beletti, M. E., Mantovani, M. M., Duarte, P. R. A., Gonçalves, A., & Resende, E. S. (2022). Physical Training Improves Cardiac Structure and Function of Rats After Doxorubicin-Induced Cardiomyopathy. International Journal of Cardiovascular Sciences, 35(6), 718-726.

Formato de Documento Eletrônico (ISO)

Souza, Fernanda Rodrigues and Campos, Érica Carolina and Lopes, Leandro Teixeira Paranhos and Rodrigues, Clesnan Mendes and Gonçalves, Danilo Lemes Naves and Beletti, Marcelo Emílio and Mantovani, Matheus Matioli and Duarte, Poliana Rodrigues Alves and Gonçalves, Alexandre and Resende, Elmiro Santos. Physical Training Improves Cardiac Structure and Function of Rats After Doxorubicin-Induced Cardiomyopathy. International Journal of Cardiovascular Sciences [online]. 2022, vol. 35, n. 6, [citado 2026-10-14], pp. 718-726. Disponível em: <https://journals.cardiol.br/article/physical-training-improves-cardiac-structure-and-function-of-rats-after-doxorubicin-induced-cardiomyopathy-2/>. ISSN 2359-4802

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