Cardiovascular Effects of the Diterpene Manool in Normotensive and Hypertensive Rats

The World Health Organization estimates that cardiovascular diseases (CVD) are the leading cause of death globally, accounting for 17.5 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030. Similarly, in Brazil, diseases of the circulatory system caused 30.68 % of the total deaths in 2014.

Hypertension is quantitatively the most important risk factor for CVD, such as stroke, myocardial infarction, and cardiac failure. The global prevalence of hypertension in adults aged 18 years and over was around 22% in 2014. The high incidence of hypertension and other CVD also generates an important economic problem since they are responsible for high rates of mortality and disability in the economically active population.

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