Metabolic and Inflammatory Relationship between Covid-19 and Non-HDL-C

The study “Prognostic Value of Non-HDL Cholesterol in COVID-19 Pneumonia” evaluated the predictive value of non-high-density lipoprotein cholesterol (non-HDL-C) in patients with SARS-CoV-2 for mortality in Covid-19 infection. The authors included 1435 patients between January 2020 and June 2022. The results showed that age, CRP, and LDH were positively correlated with non-HDL-C, and the non-surviving group was older. These results corroborate studies’ results demonstrating that several biomarkers could be used as predictive value for prognosis and mortality in Covid-19 disease.

The non-HDL-C represents a total burden of atherogenic lipoproteins, such as LDL-C, VLDL-C, IDL-C, Lp(a), and chylomicron remnant. İt may be used as a predicted risk, even in nonfasting samples when triglycerides increase. On the other hand, COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I, A-II, and B levels, while triglyceride levels may be normal or increased. The degree of reduction in total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I could be predictive of mortality. Decreased HDL-C and apolipoprotein A-I levels evaluated before COVID-19 infections would be associated with an increased risk of severe Covid-19 infections, while LDL-C, apolipoprotein B, Lp (a), and triglyceride levels would not be. Covid-19 infections alter lipid and lipoprotein levels, and HDL-C levels may affect the risk of developing Covid-19 infections.

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