Discordance of Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol with Severity of Coronary Artery Disease

Cardiovascular diseases (CVDs) are the leading cause of mortality world. Dyslipidemia is a risk and causal factor and is the focus of the therapy for primary and secondary prevention of CVDs.

There is consensus and broad understanding of the causal mechanisms of low-density lipoproteins (LDL) in CVDs, and the benefit of the hypolipidemic therapy, with a magnitude of effect proportional to the reduction in serum levels. However, despite intensive use of lipid lowering agents, there remains a residual risk, a constant target of research and therapy.

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