Brazilian Guideline on Menopausal Cardiovascular Health – 2024
1. Introduction
After the publication of the results from the Women’s Health Initiative (WHI) clinical trial in 2002 showing more risks than benefits to female health with estrogen (alone or combined with progestin) use to control menopausal signs and symptoms, there has been a progressive and sustained decline in the prescription of those drugs.–
In the United States, there was an increase in the prescription of menopausal hormone therapy (MHT) from 16 million in 1966 to 90 million in 1999,– so that, by the end of the 1990s, 25% of 45–74-year-old women and more than 40% of those aged 50-69 years were on that therapy.–
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