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  2. Keyword: Renal Insufficiency/ complications
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Extensive Myocardial Calcification in a Heart Transplant Patient

Sasha B. C. P. Duarte et al. Sandrigo Mangini Monica S. Avila Marcelo L. Montemor Fernando Bacal

A 33-year-old female patient underwent heart transplantation (Tx) for valvular heart disease, where the surgical procedure was uneventful. Post-Tx, she developed with acute graft dysfunction, acute renal failure (ARF) requiring dialysis and septic shock. Bloodstream infection confirmed by treatment for carbapenemase-producing Klebsiella pneumoniae. Non-contrast-enhanced computed tomography (CT) of the chest and abdomen was done for investigation of the infectious focus and distention of the abdomen and melena, with extensive left ventricular myocardial calcification (MC) not previously found in CT (, and ). A diagnosis of cytomegalovirus (CMV) infection was also confirmed by upper digestive endoscopy findings with diffuse gastroduodenal ulcers and quantitative detection of positive CMV DNA, and the patient received ganciclovir. The patient became refractory to treatment and died.

[…]

  • Heart Transplantation/complications
  • Heart Valve Diseases/surgery
  • Renal Insufficiency/ complications
  • Shock, Septic
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Creative Commons Attribution (CC BY) Creative Commons license
10/02/2020 DOI: 10.36660/abc.20190146 Views 1
ABC
Editorial

Impact of Transcatheter Aortic Valve Implantation on Kidney Function: the “Renovalvular” Interaction in Aortic Stenosis

Antonio de Santis

The advent of renal congestion in heart failure was first described by Frédéric Justin Collet (1870-1966), a French pathologist who found the notion of passive renal congestion related to heart dysfunction, creating the revealing term “rein cardiaque” in the early 1900s. The term cardiorenal syndrome emerged from a 2004 National Heart, Lung, and Blood Institute Working GrouP conference evaluating the complex interactions between the heart and kidney. The main pathophysiological mechanisms related to this condition are increased central venous and intra-abdominal pressures; reduced cardiac output and cardiac index; neurohormonal dysregulation; oxidative stress and inflammatory mediators. Degenerative aortic stenosis (AS) represents one of the most prevalent valvular heart diseases and an important cause of heart failure, with a strong correlation with aging process. The combination of atherosclerosis, biomineralization and oxidative stress leads to calcium deposition within the valve leaflets. The “renovalvular” interaction in AS may represent a two-way path, from a pathophysiological perspective. In one way, AS may impair kidney function by arterial hypoperfusion and systemic venous congestion. On the other way, chronic kidney disease (CKD) is also an important risk factor for AS, due to the massive and aggressive calcification of the leaflets, mainly imposed by imbalances in the calcium and phosphorus homeostasis.

For patients with AS undergoing conventional surgical aortic valve replacement (AVR), there is an increase in complication rates such as major bleeding and reoperation when comparing patients with moderately reduced kidney function (estimated glomerular filtration rate [eGFR] between 30-60 ml/min/1.73 m) versus those without kidney disease. Mortality after surgical AVR also increases with worsening GFR.

[…]

  • Aortic Valve Stenosis/complications
  • Heart Failure/complications
  • Renal Insufficiency/ complications
  • Risk Assessment
  • Transcatheter Aortic Valve Replacement/trends
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Creative Commons Attribution (CC BY) Creative Commons license
02/12/2019 DOI: 10.36660/abc.20190753 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Duarte SBCP, Mangini S, Avila MS, Montemor ML, Bacal F. Extensive Myocardial Calcification in a Heart Transplant Patient. Arquivos Brasileiros de Cardiologia 2020;114(1):133-5.

Electronic Document Format (ABNT)

Duarte, Sasha B. C. P.; Mangini, Sandrigo; Avila, Monica S.; Montemor, Marcelo L.; Bacal, Fernando. Extensive Myocardial Calcification in a Heart Transplant Patient. Arquivos Brasileiros de Cardiologia, v. 114, n. 1, p. 133-135, Feb. 2020.

Electronic Document Format (APA)

Duarte, S. B. C. P., Mangini, S., Avila, M. S., Montemor, M. L., & Bacal, F. (2020). Extensive Myocardial Calcification in a Heart Transplant Patient. Arquivos Brasileiros de Cardiologia, 114(1), 133-135.

Electronic Document Format (ISO)

Duarte, Sasha B. C. P. and Mangini, Sandrigo and Avila, Monica S. and Montemor, Marcelo L. and Bacal, Fernando. Extensive Myocardial Calcification in a Heart Transplant Patient. Arquivos Brasileiros de Cardiologia [online]. 2020, vol. 114, n. 1, [cited 2026-10-14], pp. 133-135. Available from: <https://journals.cardiol.br/en/article/extensive-myocardial-calcification-in-a-heart-transplant-patient/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Santis A. Impact of Transcatheter Aortic Valve Implantation on Kidney Function: the “Renovalvular” Interaction in Aortic Stenosis. Arquivos Brasileiros de Cardiologia 2019;113(6):1112-3.

Electronic Document Format (ABNT)

Santis, Antonio de. Impact of Transcatheter Aortic Valve Implantation on Kidney Function: the “Renovalvular” Interaction in Aortic Stenosis. Arquivos Brasileiros de Cardiologia, v. 113, n. 6, p. 1112-1113, Dec. 2019.

Electronic Document Format (APA)

Santis, A. (2019). Impact of Transcatheter Aortic Valve Implantation on Kidney Function: the “Renovalvular” Interaction in Aortic Stenosis. Arquivos Brasileiros de Cardiologia, 113(6), 1112-1113.

Electronic Document Format (ISO)

Santis, Antonio de. Impact of Transcatheter Aortic Valve Implantation on Kidney Function: the “Renovalvular” Interaction in Aortic Stenosis. Arquivos Brasileiros de Cardiologia [online]. 2019, vol. 113, n. 6, [cited 2026-10-14], pp. 1112-1113. Available from: <https://journals.cardiol.br/en/article/impact-of-transcatheter-aortic-valve-implantation-on-kidney-function-the-renovalvular-interaction-in-aortic-stenosis/>. ISSN 0066-782X

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