Fabiane Valentini Francisqueti-Ferron et al. Matheus Antônio Filiol Belin Thiago Luiz Novaga Palacio Artur Junio Togneri Ferron … Jéssica Leite Garcia Juliana Silva Siqueira Erika Tiemi Nakandakare-Maia Taynara Aparecida Vieira Hugo Tadashi Kano Fernando Moreto Giuseppina Pace Pereira Lima Camila Renata Corrêa Igor Otavio Minatel
Abstract
Background
Cardiovascular diseases (CVD) are the major cause of mortality worldwide, whose most prominent risk factor is unhealthy eating habits, such as high fructose intake. Biogenic amines (BAs) perform important functions in the human body. However, the effect of fructose consumption on BA levels is still unclear, as is the association between these and CVD risk factors.
Objective
This study aimed to establish the association between BA levels and CVD risk factors in animals that consumed fructose.
Methods
Male Wistar rats received standard chow (n=8) or standard chow + fructose in drinking water (30%) (n=8) over a 24-week period. At the end of this period, the nutritional and metabolic syndrome (MS) parameters and plasmatic BA levels were analyzed. A 5% level of significance was adopted.
Results
Fructose consumption led to MS, reduced the levels of tryptophan and 5-hydroxitryptophan, and increased histamine. Tryptophan, histamine, and dopamine showed a correlation with metabolic syndrome parameters.
Conclusion
Fructose consumption alters BAs associated with CVD risk factors.