Coronary Artery Disease (CAD) has been consistently associated with the leading cause of death and disability in most western industrialized countries since the mid-1950s. Although it still has a major impact on the health of society in these countries, CAD rates have considerably decreased in recent decades.

There are significant differences in the prevalence of CAD, as different world regions face varying stages of this epidemic. An epidemiological transition model for cardiovascular disease describes a series of stages starting from a population profile with low life expectancy and cardiovascular diseases mainly due to infectious diseases and malnutrition, which is a pattern commonly observed in developing countries. As the economic and public health development improves the population’s nutrition and decreases infectious disease rates, life expectancy increases, and the pattern and rates of cardiovascular disease are changed. In the last phase, commonly seen in high-income countries, life expectancy increases, and degenerative cardiovascular diseases at advanced age predominate. Variable rates of incidence, prevalence, and mortality reflect the different levels of risk factors, other concurrent causes of death, and the availability of resources to fight cardiovascular disease.

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