Karoline Gonzaga Costa et al. Maria Estefânia Bosco Otto André Felipe Lobão Fernandes Nathália de Macêdo Assunção … Mariana Ubaldo Barbosa Paiva Rosyane Luz Rufino de Lima Rita Mikelle Soares Dias
Introduction
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis constitute a group of systemic small-vessel inflammatory diseases characterized by pauci-immune necrotizing vasculitis and multisystem involvement, including granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA).– MPA is classically associated with rapidly progressive glomerulonephritis and alveolar hemorrhage, conditions that carry high morbidity and mortality when not promptly recognized and treated.,
In addition to predominant renal and pulmonary involvement, there is growing evidence that patients with ANCA-associated vasculitis have an increased cardiovascular risk, related not only to traditional factors but also to disease-specific mechanisms such as persistent inflammation, endothelial dysfunction, and accelerated atherosclerosis.– Studies suggest a higher incidence of major cardiovascular events (myocardial infarction, stroke, and heart failure) compared with the general population.
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