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  2. Keyword: ischemic cardiomyopathy
Clinical impact of Positron Emission Tomography by coincidence system with 18F-FDG on therapeutic decision-making of patients with ischemic cardiomyopathy after myocardial infarction
ABC
Artigo Original

Clinical impact of Positron Emission Tomography by coincidence system with 18F-FDG on therapeutic decision-making of patients with ischemic cardiomyopathy after myocardial infarction

Renata Christian Martins Felix et al. Patrícia Lavatori Correa Jader Cunha de Azevedo Hans Fernando da Rocha Dohmann … Evandro Tinoco Mesquita Cláudio Tinoco Mesquita

OBJECTIVE: To evaluate the influence of the myocardium viability study by coincidence imaging using 18F-FDG in the clinical decision-making of patients with ischemic cardiomyopathy and left ventricular dysfunction. METHODS: Thirty-one patients were submitted to myocardial viability study with 18F-FDG by coincidence imaging between September 2003 and November 2004. The physician answered a questionnaire about the choice of therapeutic procedure before and after PET. RESULTS: Twenty-seven patients (87%) had myocardial viability. Twenty-one (68%) physicians thought that PET changed the therapeutic procedure for their patients and 27(87%) considered that PET added to the therapeutic decision. The current treatment decision (clinical or revascularization) correlated with myocardial viability (p=0.006). CONCLUSIONS: Coincidence imaging is a useful tool to help physicians in a difficult decision about the best treatment for patients with ischemic cardiomyopathy. Symptoms, electrocardiogram, ejection fraction and myocardial fibrosis area did not correlate with myocardium viability, so they should not be used to decide whether to perform a myocardial viability study or not.

  • coincidence system
  • ischemic cardiomyopathy
  • Myocardial Viability
  • PET
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Creative Commons Attribution (CC BY) Creative Commons license
29/05/2006 DOI: 10.1590/S0066-782X2006000500003 Views 1
Endomyocardial biopsy foretells ventricular function recovery after coronary artery bypass grafting
ABC
Artigo Original

Endomyocardial biopsy foretells ventricular function recovery after coronary artery bypass grafting

Paulo L. Moreno et al. Orlando B. Wender Marinez Barra Lucia C. Pellanda … Luiz E. Rohde Nadine Clausell

OBJECTIVE: Patients with ischemic heart failure may benefit from coronary artery bypass grafting. The histopathological variables associated with improvement in ejection fraction 6 months after surgery were assessed. METHODS: This study comprised 24 patients indicated for coronary artery bypass grafting, ejection fraction < 35%, functional class II-IV heart failure, and mean age 59 ± 9 years. Endomyocardial biopsies were performed during and 6 months after surgery. Extension of the fibrosis, number of cells with myocytolysis, and hypertrophy of the muscle fiber were quantified by using a system of image analysis. Clinical and functional review was repeated within 6 months. RESULTS: A significant improvement in heart failure functional class was observed in 16 patients after 6 months of follow-up (from NYHA functional class 2.8±0.7 to 1.7±0.6; P <0.001), but the ejection fraction did not change (25±6 % vs. 26±10%). Hypertrophy of the muscle fiber was similar in the specimens biopsied in the pre- and postoperative periods (21±4 vs. 22± 4 µm), but the extension of fibrosis (8±8 vs. 21±15% area) and the number of cells with myocytolysis (9±11 vs. 21±15% cell) significantly increased. However, the composition of a histological score combining those 3 variables indicated a greater increase in the ventricular function of those with a lower degree of preoperative histopathological alterations. CONCLUSION: Patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting improved their ventricular function when the preoperative adverse histopathological alterations were of a lower degree.

  • coronary artery bypass grafting
  • endomyocardial biopsy
  • Heart Failure
  • ischemic cardiomyopathy
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11/11/2004 DOI: 10.1590/S0066-782X2004001700004 Views 1

How to cite this article

EndNote RIS

Electronic Document Format (Vancouver)

Felix RCM, Correa PL, Azevedo JC, Dohmann HFR, Mesquita ET, Mesquita CT. Clinical impact of Positron Emission Tomography by coincidence system with 18F-FDG on therapeutic decision-making of patients with ischemic cardiomyopathy after myocardial infarction. Arquivos Brasileiros de Cardiologia 2006;86(5):337-45.

Electronic Document Format (ABNT)

Felix, Renata Christian Martins; Correa, Patrícia Lavatori; Azevedo, Jader Cunha de; Dohmann, Hans Fernando da Rocha; Mesquita, Evandro Tinoco; Mesquita, Cláudio Tinoco. Clinical impact of Positron Emission Tomography by coincidence system with 18F-FDG on therapeutic decision-making of patients with ischemic cardiomyopathy after myocardial infarction. Arquivos Brasileiros de Cardiologia, v. 86, n. 5, p. 337-345, May. 2006.

Electronic Document Format (APA)

Felix, R. C. M., Correa, P. L., Azevedo, J. C. , Dohmann, H. F. R., Mesquita, E. T., & Mesquita, C. T. (2006). Clinical impact of Positron Emission Tomography by coincidence system with 18F-FDG on therapeutic decision-making of patients with ischemic cardiomyopathy after myocardial infarction. Arquivos Brasileiros de Cardiologia, 86(5), 337-345.

Electronic Document Format (ISO)

Felix, Renata Christian Martins and Correa, Patrícia Lavatori and Azevedo, Jader Cunha de and Dohmann, Hans Fernando da Rocha and Mesquita, Evandro Tinoco and Mesquita, Cláudio Tinoco. Clinical impact of Positron Emission Tomography by coincidence system with 18F-FDG on therapeutic decision-making of patients with ischemic cardiomyopathy after myocardial infarction. Arquivos Brasileiros de Cardiologia [online]. 2006, vol. 86, n. 5, [cited 2026-10-14], pp. 337-345. Available from: <https://journals.cardiol.br/en/article/clinical-impact-of-positron-emission-tomography-by-coincidence-system-with-18f-fdg-on-therapeutic-decision-making-of-patients-with-ischemic-cardiomyopathy-after-myocardial-infarction/>. ISSN 0066-782X

EndNote RIS

Electronic Document Format (Vancouver)

Moreno PL, Wender OB, Barra M, Pellanda LC, Rohde LE, Clausell N. Endomyocardial biopsy foretells ventricular function recovery after coronary artery bypass grafting. Arquivos Brasileiros de Cardiologia 2004;83(5):373-8.

Electronic Document Format (ABNT)

Moreno, Paulo L.; Wender, Orlando B.; Barra, Marinez; Pellanda, Lucia C.; Rohde, Luiz E.; Clausell, Nadine. Endomyocardial biopsy foretells ventricular function recovery after coronary artery bypass grafting. Arquivos Brasileiros de Cardiologia, v. 83, n. 5, p. 373-378, Nov. 2004.

Electronic Document Format (APA)

Moreno, P. L., Wender, O. B., Barra, M., Pellanda, L. C., Rohde, L. E., & Clausell, N. (2004). Endomyocardial biopsy foretells ventricular function recovery after coronary artery bypass grafting. Arquivos Brasileiros de Cardiologia, 83(5), 373-378.

Electronic Document Format (ISO)

Moreno, Paulo L. and Wender, Orlando B. and Barra, Marinez and Pellanda, Lucia C. and Rohde, Luiz E. and Clausell, Nadine. Endomyocardial biopsy foretells ventricular function recovery after coronary artery bypass grafting. Arquivos Brasileiros de Cardiologia [online]. 2004, vol. 83, n. 5, [cited 2026-10-14], pp. 373-378. Available from: <https://journals.cardiol.br/en/article/endomyocardial-biopsy-foretells-ventricular-function-recovery-after-coronary-artery-bypass-grafting/>. ISSN 0066-782X

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